Mortality of Parkinson's disease by Hoehn-Yahr stage from community-based and clinic series [keelung Community-based Integrated Screening (KCIS) no. 17)]

Horng Huei Liou, Chia Yun Wu, Yueh Hsia Chiu, Amy Ming Fang Yen, Rong Chi Chen, Ta Fu Chen, Chih Chuan Chen, Yuarn Chung Hwang, Ying Rong Wen, Tony Hsiu Hsi Chen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose We aimed to quantify the mortality reduction by which the early detection of Parkinson's disease (PD) within a community-based study could reduce the number of advanced cases. Methods Data used in this study were derived from two community-based surveys and from a clinical series of PD cases identified from a medical centre. The cumulative survival by Hoehn-Yahr (H-Y) scale was estimated and the mortality reduction derived from a community-based survey was predicted. Results A total of 117 PD patients were detected through two community-based approaches. By comparing the H-Y stage distribution of screen-detected cases with those from the clinical series, a 22.5% excess in the number of early PD (H-Y stage I and stage II) were identified with screening. The risk ratios of being H-Y stage III or severe for community-based detected cases versus clinical series were 0.49 (95% confidence interval: 0.30-0.78). The total death rate adjusted by H-Y stage distribution was 21% and 28% for cases from community and clinical series, respectively. Conclusions The present study revealed that early detection of PD through a community-based survey may reduce 51% incidence of stage III or more severe PD at diagnosis, leading to a 25% reduction in mortality.

Original languageEnglish
Pages (from-to)587-591
Number of pages5
JournalJournal of Evaluation in Clinical Practice
Volume15
Issue number4
DOIs
Publication statusPublished - Aug 2009
Externally publishedYes

Keywords

  • Early detection
  • Hoehn-Yahr stage
  • Parkinson's disease
  • Survival

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health Policy

Fingerprint Dive into the research topics of 'Mortality of Parkinson's disease by Hoehn-Yahr stage from community-based and clinic series [keelung Community-based Integrated Screening (KCIS) no. 17)]'. Together they form a unique fingerprint.

Cite this