More than 9-times increased risk for pancreatic cancer among patients with acute pancreatitis in chinese population

Shiu Dong Chung, Kuan Yang Chen, Sudha Xirasagar, Ming Chieh Tsai, Herng Ching Lin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: This study aimed to assess the risk of pancreatic cancer after acute pancreatitis using a nationwide population-based data set in Taiwan. Methods: We conducted a retrospective cohort study of 747 patients hospitalized between 2000 and 2003 with a principal diagnosis of acute pancreatitis (the study cohort) and 5976 comparison patients. Stratified Cox proportional hazard regression adjusted for monthly income, urbanization, and geographic location of residence was used to calculate the 5-year hazard ratio (HR) of pancreatic cancer for the study versus comparison cohort. Results: Of the total sample, 21 patients (0.31%) developed pancreatic cancer in the 5 years after index hospitalization: 11 (1.47%) of the study group patients and 10 (0.17%) of the comparison group patients. After adjusting for confounders, acute pancreatitis patients were 9 times as likely as the comparison group to develop pancreatic cancer in the following 5 years (HR = 9.10; 95% confidence interval, 3.81-21.76). Among patients with acute pancreatitis, the adjusted HR of pancreatic cancer was 40.03 and 3.72 times greater, respectively, for those with chronic pancreatitis and for those without than comparison patients. Conclusions: Patients with acute pancreatitis have more than 9 times the risk of comparison patients to develop pancreatic cancer in the subsequent 5 years among the Hun Chinese ethnic population in Taiwan.

Original languageEnglish
Pages (from-to)142-146
Number of pages5
JournalPancreas
Volume41
Issue number1
DOIs
Publication statusPublished - Jan 2012

Fingerprint

Pancreatic Neoplasms
Pancreatitis
Population
Taiwan
Cohort Studies
Geographic Locations
Urbanization
Chronic Pancreatitis
Hospitalization
Retrospective Studies
Confidence Intervals

Keywords

  • acute pancreatitis
  • pancreatic cancer
  • pancreatitis

ASJC Scopus subject areas

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

More than 9-times increased risk for pancreatic cancer among patients with acute pancreatitis in chinese population. / Chung, Shiu Dong; Chen, Kuan Yang; Xirasagar, Sudha; Tsai, Ming Chieh; Lin, Herng Ching.

In: Pancreas, Vol. 41, No. 1, 01.2012, p. 142-146.

Research output: Contribution to journalArticle

Chung, Shiu Dong ; Chen, Kuan Yang ; Xirasagar, Sudha ; Tsai, Ming Chieh ; Lin, Herng Ching. / More than 9-times increased risk for pancreatic cancer among patients with acute pancreatitis in chinese population. In: Pancreas. 2012 ; Vol. 41, No. 1. pp. 142-146.
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