Morbidity and mortality of very low birth weight infants in Taiwan—Changes in 15 years: A population based study

Yi Yu Su, Shih Hsin Wang, Hung Chieh Chou, Chien Yi Chen, Wu Shiun Hsieh, Po Nien Tsao, Kuo Inn Tsou, Chyong Hsin Hsu, Shu Chi Mu, Hung Chih Lin, Chao Ching Huang, Kai Sheng Hsieh, Taiwan Premature Infant Follow-up Network

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background/Purpose Very low birth weight (VLBW) infants account for over 50% of perinatal deaths in Taiwan. This study aimed to identify changes in parental characteristics, perinatal conditions, mortality, and major neonatal morbidities for VLBW infants in Taiwan, and to highlight the challenges faced by patients, families, and caregivers. Methods We conducted a retrospective cohort study to investigate the mortality and morbidity of VLBW infants registered in the Taiwan Premature Infant Follow-up Network from 1997 through 2011. The exclusion criteria included congenital anomalies and chromosome anomalies. Continuous data was represented as mean ± SD, and changes over time in the variables were tested using one-way analysis of variance, with p < 0.05 considered statistically significant. Results A total of 13,159 VLBW infants were enrolled. We found significant increases over time in the parental age and educational level, in vitro fertilization, first livebirth, multiple births, maternal transfer, cesarean section, and complete antenatal steroid use. Apgar scores at 1 minute and 5 minutes after birth increased, and the intubation rate decreased gradually. Decreasing mortality over time for each successive period was demonstrated. Incidence of some morbidities increased, such as respiratory distress syndrome and patent ductus arteriosus; in contrast, incidence of others decreased, such as sepsis, necrotizing enterocolitis, intraventricular hemorrhage, and chronic lung disease. However, retinopathy of prematurity (ROP) incidence remained constant. Conclusion Although the mortality and most of the morbidity of VLBW infants improved over time, the incidence of ROP remained constant. This requires us to further evaluate our strategy for preventing ROP in the future.

Original languageEnglish
Pages (from-to)1039-1045
Number of pages7
JournalJournal of the Formosan Medical Association
Volume115
Issue number12
DOIs
Publication statusPublished - Dec 1 2016
Externally publishedYes

Fingerprint

Very Low Birth Weight Infant
Retinopathy of Prematurity
Morbidity
Taiwan
Mortality
Population
Incidence
Multiple Birth Offspring
Necrotizing Enterocolitis
Patent Ductus Arteriosus
Apgar Score
Perinatal Mortality
Fertilization
Intubation
Premature Infants
Cesarean Section
Caregivers
Lung Diseases
Sepsis
Analysis of Variance

Keywords

  • morbidity
  • mortality
  • very low birth weight infant

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Su, Y. Y., Wang, S. H., Chou, H. C., Chen, C. Y., Hsieh, W. S., Tsao, P. N., ... Taiwan Premature Infant Follow-up Network (2016). Morbidity and mortality of very low birth weight infants in Taiwan—Changes in 15 years: A population based study. Journal of the Formosan Medical Association, 115(12), 1039-1045. https://doi.org/10.1016/j.jfma.2016.10.011

Morbidity and mortality of very low birth weight infants in Taiwan—Changes in 15 years : A population based study. / Su, Yi Yu; Wang, Shih Hsin; Chou, Hung Chieh; Chen, Chien Yi; Hsieh, Wu Shiun; Tsao, Po Nien; Tsou, Kuo Inn; Hsu, Chyong Hsin; Mu, Shu Chi; Lin, Hung Chih; Huang, Chao Ching; Hsieh, Kai Sheng; Taiwan Premature Infant Follow-up Network.

In: Journal of the Formosan Medical Association, Vol. 115, No. 12, 01.12.2016, p. 1039-1045.

Research output: Contribution to journalArticle

Su, YY, Wang, SH, Chou, HC, Chen, CY, Hsieh, WS, Tsao, PN, Tsou, KI, Hsu, CH, Mu, SC, Lin, HC, Huang, CC, Hsieh, KS & Taiwan Premature Infant Follow-up Network 2016, 'Morbidity and mortality of very low birth weight infants in Taiwan—Changes in 15 years: A population based study', Journal of the Formosan Medical Association, vol. 115, no. 12, pp. 1039-1045. https://doi.org/10.1016/j.jfma.2016.10.011
Su, Yi Yu ; Wang, Shih Hsin ; Chou, Hung Chieh ; Chen, Chien Yi ; Hsieh, Wu Shiun ; Tsao, Po Nien ; Tsou, Kuo Inn ; Hsu, Chyong Hsin ; Mu, Shu Chi ; Lin, Hung Chih ; Huang, Chao Ching ; Hsieh, Kai Sheng ; Taiwan Premature Infant Follow-up Network. / Morbidity and mortality of very low birth weight infants in Taiwan—Changes in 15 years : A population based study. In: Journal of the Formosan Medical Association. 2016 ; Vol. 115, No. 12. pp. 1039-1045.
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AU - Hsieh, Wu Shiun

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AU - Tsou, Kuo Inn

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AB - Background/Purpose Very low birth weight (VLBW) infants account for over 50% of perinatal deaths in Taiwan. This study aimed to identify changes in parental characteristics, perinatal conditions, mortality, and major neonatal morbidities for VLBW infants in Taiwan, and to highlight the challenges faced by patients, families, and caregivers. Methods We conducted a retrospective cohort study to investigate the mortality and morbidity of VLBW infants registered in the Taiwan Premature Infant Follow-up Network from 1997 through 2011. The exclusion criteria included congenital anomalies and chromosome anomalies. Continuous data was represented as mean ± SD, and changes over time in the variables were tested using one-way analysis of variance, with p < 0.05 considered statistically significant. Results A total of 13,159 VLBW infants were enrolled. We found significant increases over time in the parental age and educational level, in vitro fertilization, first livebirth, multiple births, maternal transfer, cesarean section, and complete antenatal steroid use. Apgar scores at 1 minute and 5 minutes after birth increased, and the intubation rate decreased gradually. Decreasing mortality over time for each successive period was demonstrated. Incidence of some morbidities increased, such as respiratory distress syndrome and patent ductus arteriosus; in contrast, incidence of others decreased, such as sepsis, necrotizing enterocolitis, intraventricular hemorrhage, and chronic lung disease. However, retinopathy of prematurity (ROP) incidence remained constant. Conclusion Although the mortality and most of the morbidity of VLBW infants improved over time, the incidence of ROP remained constant. This requires us to further evaluate our strategy for preventing ROP in the future.

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