Montelukast as monotherapy in children with mild persistent asthma

Wei Fong Wu, Jiunn Ren Wu, Zen Kong Dai, Chin Wen Tsai, Tzu Chun Tsai, Chia Chun Chen, Chueh Yuan Yang

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The cysteinyl leukotrienes cause bronchoconstriction, increased mucus production and airway inflammation, three major features of asthma. Several randomized controlled trials have shown the efficacy of leukotriene receptor antagonists for improving asthma outcomes. The drug is favored for treating childhood asthma, where poor compliance with inhalation therapy is a therapeutic challenge. To assess the effectiveness of Montelukast in asthmatic children under real-life conditions, a prospective, single-arm, multicenter, open-label observational study was performed on asthmatic children 2 to 14 years old with a history of physician-diagnosed mild persistent asthma. Montelukast was given once daily for 12 consecutive weeks. By the end a significant improvement of the daytime asthma symptom score, nighttime asthma score, peak expiratory flow rate (PEFR) and mean score of the investigators' global evaluation was noted (p < 0.05). These results suggest that montelukast is an effective monotherapy controller in children with mild persistent asthma.

Original languageEnglish
Pages (from-to)173-180
Number of pages8
JournalAsian Pacific Journal of Allergy and Immunology
Volume27
Issue number4
Publication statusPublished - Dec 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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