Monitoring medical abortion using mifepristone/misoprostol combination with ultrasonogram and serum human chorionic gonadotropin

Szu-Yuan Chou, Chih Yen Chen, Huihua Kenny Chiang, Pui Ki Chow, Ching Chiung Wang, Chun-Sen Hsu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: The oral mifepristone/misoprostol combination (MMC) is safe for medical abortion in early pregnancy. The abortion status in MMC-treated pregnancies at Taipei Medical University-Wan Fang Medical Center was determined by ultrasonography, serum β-human chorionic gonadotropin (β-HCG), and histopathology. Methods: All women at less than 49 days since the last menstruation who asked for legal abortion were evaluated by ultrasonography. They then received 600 mg of oral mifepristone followed 48 hours later by 600 μg of misoprostol. Women who had vaginal spotting or bleeding after 14 days were included in this study and underwent transvaginal ultrasonography, serum β-HCG measurement and vacuum aspiration or therapeutic dilatation and curettage (D&C) on day 14. Specimens were identified by histopathology. Abortion status was determined from linear regression of serum β-HCG and endometrial thickness. Results: Of 35 women who underwent vacuum aspiration or therapeutic D&C, histopathology showed that 20 had decidual tissue and 15 had gestational tissue. Logistic regression showed that the distance measurement to the logistic regression line differed significantly between complete and incomplete abortion (p <0.05). Conclusion: In this study, serum β-HCG assays in addition to ultrasonographic evaluation helped to discriminate abortion status after oral MMC.

Original languageEnglish
Pages (from-to)48-52
Number of pages5
JournalTaiwanese Journal of Obstetrics and Gynecology
Volume45
Issue number1
Publication statusPublished - Mar 2006

Fingerprint

Misoprostol
Mifepristone
Chorionic Gonadotropin
Dilatation and Curettage
Ultrasonography
Vacuum
Serum
Incomplete Abortion
Logistic Models
Legal Abortion
Pregnancy
Metrorrhagia
Menstruation
Linear Models
Hemorrhage
Therapeutics

Keywords

  • Early pregnancy
  • Incomplete abortion
  • Mifepristone
  • Misoprostol

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Monitoring medical abortion using mifepristone/misoprostol combination with ultrasonogram and serum human chorionic gonadotropin. / Chou, Szu-Yuan; Chen, Chih Yen; Chiang, Huihua Kenny; Chow, Pui Ki; Wang, Ching Chiung; Hsu, Chun-Sen.

In: Taiwanese Journal of Obstetrics and Gynecology, Vol. 45, No. 1, 03.2006, p. 48-52.

Research output: Contribution to journalArticle

Chou, Szu-Yuan ; Chen, Chih Yen ; Chiang, Huihua Kenny ; Chow, Pui Ki ; Wang, Ching Chiung ; Hsu, Chun-Sen. / Monitoring medical abortion using mifepristone/misoprostol combination with ultrasonogram and serum human chorionic gonadotropin. In: Taiwanese Journal of Obstetrics and Gynecology. 2006 ; Vol. 45, No. 1. pp. 48-52.
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