Molecular structure of the octamer d(G-G-C-C-G-G-C-C): modified A-DNA.

A. H. Wang, S. Fujii, J. H. van Boom, A. Rich

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224 Citations (Scopus)


The deoxynucleotide fragment d(GpGpCpCpGpGpCpC) was synthesized and crystallized, and its three-dimensional structure was determined by x-ray diffraction techniques to a resolution of 2.25 A. The molecule forms a right-handed double helix in which the two base pairs at either end of the molecule are in the conventional A-DNA conformation, while the central four base pairs have a modified form in which alternate residues have sugar conformations that are closer to those in B-DNA than in A-DNA. The molecules have an intermolecular contact in which the planar terminal guanine . cytosine base pair lies on the flat minor groove surface of the A-DNA helix.

Original languageEnglish
Pages (from-to)3968-3972
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number13
Publication statusPublished - Jul 1982
Externally publishedYes

ASJC Scopus subject areas

  • General


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