Molecular structure of r(GCG)d(TATACGC): A DNA-RNA hybrid helix joined to double helical DNA

Andrew H.J. Wang, Satoshi Fujii, Jacques H. Van Boom, Gijs A. Van Der Marel, Stan A.A. Van Boeckel, Alexander Rich

Research output: Contribution to journalArticlepeer-review

196 Citations (Scopus)

Abstract

The molecule r(GCG)d(TATACGC) is self-complementary and forms two DNA-RNA hybrid segments surrounding a central region of double helical DNA its molecular structure has been solved by X-ray analysis. All three parts of the molecule adopt a conformation which is close to that seen in the 11-fold RNA double helix. The conformation of the ribonucleotides is partly determined by water molecules bridging between the ribose O2′ hydroxyl group and cytosine O2. The hybrid-DNA duplex junction contains no structural discontinuities. However, the central DNA TATA sequence has some structural irregularities.

Original languageEnglish
Pages (from-to)601-604
Number of pages4
JournalNature
Volume299
Issue number5884
DOIs
Publication statusPublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • General

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