Molecular structure of a left-Handed double helical DNA fragment at atomic resolution

Andrew H.J. Wang, Gary J. Quigley, Francis J. Kolpak, James L. Crawford, Jacques H. Van Boom, Gijs Van Der Marel, Alexander Rich

Research output: Contribution to journalArticlepeer-review

1577 Citations (Scopus)

Abstract

The DNA fragment d(CpGpCpGpCpG) crystallises as a left-handed double helical molecule with Watson-Crick base pairs and an antiparallel organisation of the sugar phosphate chains. The helix has two nucleotides in the asymmetric unit and contains twelve base pairs per turn. It differs significantly from right-handed B-DNA.

Original languageEnglish
Pages (from-to)680-686
Number of pages7
JournalNature
Volume282
Issue number5740
DOIs
Publication statusPublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • General

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