Molecular Regulation of Phosphate Metabolism by Fibroblast Growth Factor-23-Klotho System

Chung Yi Cheng, Makoto Kuro-o, Mohammed S. Razzaque

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Phosphorus is an essential nutrient and is routinely assimilated through consumption of food. The body's need of phosphate is usually fulfilled by intestinal absorption of this element from the consumed food, whereas its serum level is tightly regulated by renal excretion or reabsorption. Sodium-dependent phosphate transporters, located in the luminal side of the proximal tubular epithelial cells, have a molecular control on renal phosphate excretion and reabsorption. The systemic regulation of phosphate metabolism is a complex multiorgan process, and the identification of fibroblast growth factor-23 (FGF23)-Klotho system as a potent phosphatonin has provided new mechanistic insights into the homeostatic control of phosphate. Hypophosphatemia as a result of an increase in urinary phosphate wasting after activation of the FGF23-Klotho system is a common phenomenon, observed in both animal and human studies, whereas suppression of the FGF23-Klotho system leads to the development of hyperphosphatemia. This article will briefly summarize how delicate interactions of the FGF23-klotho system can regulate systemic phosphate homeostasis.

Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalAdvances in Chronic Kidney Disease
Volume18
Issue number2
DOIs
Publication statusPublished - Mar 2011
Externally publishedYes

Fingerprint

Phosphates
Food
Sodium-Phosphate Cotransporter Proteins
Hyperphosphatemia
Hypophosphatemia
Intestinal Absorption
Phosphorus
fibroblast growth factor 23
Homeostasis
Epithelial Cells
Serum
Renal Elimination
Renal Reabsorption

Keywords

  • Calcium
  • FGF23
  • Klotho
  • NaPi
  • PTH
  • Vitamin D

ASJC Scopus subject areas

  • Nephrology

Cite this

Molecular Regulation of Phosphate Metabolism by Fibroblast Growth Factor-23-Klotho System. / Cheng, Chung Yi; Kuro-o, Makoto; Razzaque, Mohammed S.

In: Advances in Chronic Kidney Disease, Vol. 18, No. 2, 03.2011, p. 91-97.

Research output: Contribution to journalArticle

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