Molecular epidemiology of multidrug-resistant Mycobacterium tuberculosis in Eastern Taiwan

A. H. Hsu, C. B. Lin, Y. S. Lee, C. Y. Chiang, L. K. Chen, Y. S. Tsai, Jen Jyh Lee

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12 Citations (Scopus)

Abstract

Taiwan initiated a multidrug-resistant tuberculosis (MDR-TB) programme in May 2007. Seventy-seven MDR-TB patients were enrolled from May 2007 to February 2009 in Eastern Taiwan. Isolates of 73 (94%) patients were available for genotyping using spoligotyping and MIRU-VNTR (mycobacterial interspersed repetitive unit-v ariable number of tandem repeats). Spoligotyping results indicated the Beijing strain as the predominant genotype (n = 48, 66%). Of the 73 isolates, 28 (38.4%) had a unique pattern and 45 (61.6%) were clustered pattern strains. Epidemiological links could be established in 21 (46.7%) of the 45 patients with a clustered pattern strain. The proportion of MDR-TB patients with a clustered pattern strain in Eastern Taiwan was high.

Original languageEnglish
Pages (from-to)924-926
Number of pages3
JournalInternational Journal of Tuberculosis and Lung Disease
Volume14
Issue number7
Publication statusPublished - 2010
Externally publishedYes

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Keywords

  • MIRU-VNTR
  • Multidrug-resistant tuberculosis
  • Spoligo-typing
  • Transmission

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases
  • Medicine(all)

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