Molecular epidemiology of HIV-1 subtype B, CRF01-AE, and CRF07-BC infection among injection drug users in Taiwan

Yen Ju Chen, Yu Huei Huang, Shao Yuan Chuang, Diana Yu Ting Kao, Yu Ching Lan, Jyh Yuan Yang, Yi Ming Arthur Chen

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

OBJECTIVE: An explosive outbreak of HIV-1 circulating recombinant form (CRF) 07-BC among injection drug users (IDUs) in Taiwan was first reported in 2004 and reach the peak in 2005. The objectives of this study were to investigate the molecular epidemiology of different HIV-1 subtypes and their associated risk factors among Taiwanese IDUs in 2004 and 2005. METHODS: Questionnaires and blood specimens were collected from inmates from 4 detention centers and 2 prisons. HIV-1 subtypes were determined using nested polymerase chain reactions with multiplex primers and phylogenetic analyses. A case-control study was conducted to elucidate risk factors associated with CRF07-BC infection. RESULTS: A total of 93.8%, 4%, and 2.2% of 451 inmates with IDU history were infected with CRF07-BC, subtype B, and CRF01-AE, respectively. Besides CRF07-BC, a new outbreak of CRF01-AE infection was identified among IDUs from central region. Multivariate analysis showed that sharing dissolved heroine solution [odds ratio (OR) = 17.2], sharing syringes (OR = 34), number of persons sharing syringes (2 vs. 1, OR = 3.1), and lower educational level (OR = 2.3) were risk factors associated with CRF07-BC infection. CONCLUSIONS: Sharing dissolved heroine solution is a neglected risk factor associated with HIV-1 infection and it should be emphasized in the AIDS education and harm reduction programs immediately.

Original languageEnglish
Pages (from-to)425-439
Number of pages15
JournalJournal of Acquired Immune Deficiency Syndromes
Volume53
Issue number4
DOIs
Publication statusPublished - Apr 1 2010
Externally publishedYes

Fingerprint

Molecular Epidemiology
Drug Users
Taiwan
HIV-1
Odds Ratio
Needle Sharing
Injections
Infection
Disease Outbreaks
Harm Reduction
Prisons
HIV Infections
Case-Control Studies
Acquired Immunodeficiency Syndrome
Multivariate Analysis
History
Education
Polymerase Chain Reaction

Keywords

  • CRF01-AE
  • CRF07-BC
  • HIV
  • Injection drug users
  • Risk factors
  • Sharing dissolved heroine solution
  • Sharing syringes

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Molecular epidemiology of HIV-1 subtype B, CRF01-AE, and CRF07-BC infection among injection drug users in Taiwan. / Chen, Yen Ju; Huang, Yu Huei; Chuang, Shao Yuan; Kao, Diana Yu Ting; Lan, Yu Ching; Yang, Jyh Yuan; Chen, Yi Ming Arthur.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 53, No. 4, 01.04.2010, p. 425-439.

Research output: Contribution to journalArticle

Chen, Yen Ju ; Huang, Yu Huei ; Chuang, Shao Yuan ; Kao, Diana Yu Ting ; Lan, Yu Ching ; Yang, Jyh Yuan ; Chen, Yi Ming Arthur. / Molecular epidemiology of HIV-1 subtype B, CRF01-AE, and CRF07-BC infection among injection drug users in Taiwan. In: Journal of Acquired Immune Deficiency Syndromes. 2010 ; Vol. 53, No. 4. pp. 425-439.
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AU - Chuang, Shao Yuan

AU - Kao, Diana Yu Ting

AU - Lan, Yu Ching

AU - Yang, Jyh Yuan

AU - Chen, Yi Ming Arthur

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N2 - OBJECTIVE: An explosive outbreak of HIV-1 circulating recombinant form (CRF) 07-BC among injection drug users (IDUs) in Taiwan was first reported in 2004 and reach the peak in 2005. The objectives of this study were to investigate the molecular epidemiology of different HIV-1 subtypes and their associated risk factors among Taiwanese IDUs in 2004 and 2005. METHODS: Questionnaires and blood specimens were collected from inmates from 4 detention centers and 2 prisons. HIV-1 subtypes were determined using nested polymerase chain reactions with multiplex primers and phylogenetic analyses. A case-control study was conducted to elucidate risk factors associated with CRF07-BC infection. RESULTS: A total of 93.8%, 4%, and 2.2% of 451 inmates with IDU history were infected with CRF07-BC, subtype B, and CRF01-AE, respectively. Besides CRF07-BC, a new outbreak of CRF01-AE infection was identified among IDUs from central region. Multivariate analysis showed that sharing dissolved heroine solution [odds ratio (OR) = 17.2], sharing syringes (OR = 34), number of persons sharing syringes (2 vs. 1, OR = 3.1), and lower educational level (OR = 2.3) were risk factors associated with CRF07-BC infection. CONCLUSIONS: Sharing dissolved heroine solution is a neglected risk factor associated with HIV-1 infection and it should be emphasized in the AIDS education and harm reduction programs immediately.

AB - OBJECTIVE: An explosive outbreak of HIV-1 circulating recombinant form (CRF) 07-BC among injection drug users (IDUs) in Taiwan was first reported in 2004 and reach the peak in 2005. The objectives of this study were to investigate the molecular epidemiology of different HIV-1 subtypes and their associated risk factors among Taiwanese IDUs in 2004 and 2005. METHODS: Questionnaires and blood specimens were collected from inmates from 4 detention centers and 2 prisons. HIV-1 subtypes were determined using nested polymerase chain reactions with multiplex primers and phylogenetic analyses. A case-control study was conducted to elucidate risk factors associated with CRF07-BC infection. RESULTS: A total of 93.8%, 4%, and 2.2% of 451 inmates with IDU history were infected with CRF07-BC, subtype B, and CRF01-AE, respectively. Besides CRF07-BC, a new outbreak of CRF01-AE infection was identified among IDUs from central region. Multivariate analysis showed that sharing dissolved heroine solution [odds ratio (OR) = 17.2], sharing syringes (OR = 34), number of persons sharing syringes (2 vs. 1, OR = 3.1), and lower educational level (OR = 2.3) were risk factors associated with CRF07-BC infection. CONCLUSIONS: Sharing dissolved heroine solution is a neglected risk factor associated with HIV-1 infection and it should be emphasized in the AIDS education and harm reduction programs immediately.

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