Molecular epidemiology and trends of HIV-1 subtypes in Taiwan

Yi Ming A. Chen, Cheng Ming Lee, Ruei Yi Lin, Hong Jen Chang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

To understand the trends of distribution and risk factors associated with different HIV-I subtypes in different populations in Taiwan, blood samples and questionnaires were collected from 267 male and 21 female HIV-1- infected people in a multicenter survey from 1993 to 1996. This group represented about one quarter of the total registered HIV-1 cases in Taiwan. The HIV-1 subtypes were determined using V3-based peptide-enzyme immunoassays complemented by heteroduplex mobility assay and phylogenetic tree analysis. The results showed that in Taiwan, men were primarily infected with HIV-1B (68.2%) and HIV-1E (27.3%), whereas women were mainly infected with non-B subtypes (4.8% A, 4.8% C, 71.4% E, and 9.5% G). In addition, 71.4% of men with HIV-1B were homosexual or bisexual, whereas 56.2% of men with HIV-1E were heterosexual (p < .001). Although HIV-1E subtype came to Taiwan later than HIV-1B, it has become a major subtype in the heterosexual population.

Original languageEnglish
Pages (from-to)393-402
Number of pages10
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume19
Issue number4
DOIs
Publication statusPublished - Dec 1 1998
Externally publishedYes

Keywords

  • Heteroduplex mobility assay
  • HIV-1 genetic sequences
  • HIV-1 subtypes
  • Molecular epidemiology
  • Taiwan

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

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