Molecular detection of rifabutin-susceptible Mycobacterium tuberculosis

Huang Yao Chen, Ming Chih Yu, Wei Lun Huang, Mei Hua Wu, Yung Lin Chang, Chien Rai Che, Ruwen Jou

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14 Citations (Scopus)

Abstract

Rapid assays are still needed to detect rifabutin (RFB) susceptibility for proper tuberculosis treatment. To assess the use of the GenoType MTBDRplus assay and subsequent rpoB gene sequencing on detection of RFB susceptibility, we analyzed 800 multidrug- resistant Mycobacterium tuberculosis isolates, and 13% (104/800) were RFB susceptible. Of the 104 RFB-susceptible isolates, 71 (68.3%) isolates were rapidly identified using two molecular assays, while the remaining isolates could be determined using conventional drug-susceptibility testing according to the clinician's decision.

Original languageEnglish
Pages (from-to)2085-2088
Number of pages4
JournalJournal of Clinical Microbiology
Volume50
Issue number6
DOIs
Publication statusPublished - Jun 2012

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ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Chen, H. Y., Yu, M. C., Huang, W. L., Wu, M. H., Chang, Y. L., Che, C. R., & Jou, R. (2012). Molecular detection of rifabutin-susceptible Mycobacterium tuberculosis. Journal of Clinical Microbiology, 50(6), 2085-2088. https://doi.org/10.1128/JCM.00652-12