Modulation of pulmonary allergic responses by mucosal cytokine-gene transfer

Shau Ku Huang, Xiu Min Li

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Recent clinical and experimental animal studies have provided evidence for a pivotal role of T lymphocytes and Th2 cytokines in the development of allergic inflammatory responses and airway hyperreactivity. These studies suggest also that the Th2 cytokine-associated inflammatory responses are potential targets of developing novel and effective therapies. Using a novel gene-transfer approach, we investigated the role of a Th2-inhibitory cytokine, IFN-?, in the regulation of antigen (Ag)-induced lung inflammatory response and airway hyperreactivity by transfer of the IFN-? gene into mouse lung mucosal cells. Our results showed that mice receiving the IFN-? gene demonstrate a lower degree of Ag- and Th2 cell-induced airway hyperresponsiveness and a reduced eosinophilia in the lung. These results provided evidence that the instillation of the IFN-y gene into the lung is effective in modulating the allergic inflammation and bronchial hyperreactivity in an experimental animal model.

Original languageEnglish
Pages (from-to)11-15
Number of pages5
JournalAllergology International
Volume46
Issue number1
DOIs
Publication statusPublished - Jan 1 1997
Externally publishedYes

Keywords

  • airway hyperreactivity
  • allergic inflammation
  • gene transfer
  • Th2 cytokines

ASJC Scopus subject areas

  • Immunology and Allergy

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