Modulation of Mitotic Signal Transduction by Curcumin and Tea Polyphenols and Their Implication for Cancer Chemoprevention

Jen Kun Lin, Yu Chih Liang, Yu Li Lin, Yen Chou Chen, Shoei Yn Lin Shiau

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

It has been demonstrated that diets rich in fruits and vegetables are protective aganist cardiovascular diseases and certain forms of cancer. These protective effects have been attributed to the anti-oxidant present, including vitamin C, Carotenes and phytopolyphenols. The polyphenolic components of higher plants may act as anti-oxidants (sometimes may be as pro-oxidants), or as agents of other mechanisms, contributing to the anti-carcinogenic or cadioprotective action. Curcumin is a widely used dietary pigment (curry), and this polyphenolic compound has been demonstrated to be an inhibitor of tumor promotion in chemical carcinogenesis. Recent studies also indicate that tea polyphenols are active in inhibiting the processes of carcinogenesis induced by various carcinogens. Investigations from this laboratory and others have indicated that modulation of mitotic signal transduction may attribute, in part, to the molecular mechanisms of these cancer chemopreventive agents.

Original languageEnglish
Pages (from-to)225-238
Number of pages14
JournalACS Symposium Series
Volume701
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Signal transduction
Curcumin
Polyphenols
Oxidants
Polyphenolic compounds
Modulation
Vegetables
Carotenoids
Nutrition
Fruits
Pigments
Carcinogens
Ascorbic Acid
Tumors
Reactive Oxygen Species
Vitamins
Tea
Chemoprevention

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Modulation of Mitotic Signal Transduction by Curcumin and Tea Polyphenols and Their Implication for Cancer Chemoprevention. / Lin, Jen Kun; Liang, Yu Chih; Lin, Yu Li; Chen, Yen Chou; Shiau, Shoei Yn Lin.

In: ACS Symposium Series, Vol. 701, 1998, p. 225-238.

Research output: Contribution to journalArticle

@article{138777b233f3439681b66291f8fdb072,
title = "Modulation of Mitotic Signal Transduction by Curcumin and Tea Polyphenols and Their Implication for Cancer Chemoprevention",
abstract = "It has been demonstrated that diets rich in fruits and vegetables are protective aganist cardiovascular diseases and certain forms of cancer. These protective effects have been attributed to the anti-oxidant present, including vitamin C, Carotenes and phytopolyphenols. The polyphenolic components of higher plants may act as anti-oxidants (sometimes may be as pro-oxidants), or as agents of other mechanisms, contributing to the anti-carcinogenic or cadioprotective action. Curcumin is a widely used dietary pigment (curry), and this polyphenolic compound has been demonstrated to be an inhibitor of tumor promotion in chemical carcinogenesis. Recent studies also indicate that tea polyphenols are active in inhibiting the processes of carcinogenesis induced by various carcinogens. Investigations from this laboratory and others have indicated that modulation of mitotic signal transduction may attribute, in part, to the molecular mechanisms of these cancer chemopreventive agents.",
author = "Lin, {Jen Kun} and Liang, {Yu Chih} and Lin, {Yu Li} and Chen, {Yen Chou} and Shiau, {Shoei Yn Lin}",
year = "1998",
language = "English",
volume = "701",
pages = "225--238",
journal = "ACS Symposium Series",
issn = "0097-6156",
publisher = "American Chemical Society",

}

TY - JOUR

T1 - Modulation of Mitotic Signal Transduction by Curcumin and Tea Polyphenols and Their Implication for Cancer Chemoprevention

AU - Lin, Jen Kun

AU - Liang, Yu Chih

AU - Lin, Yu Li

AU - Chen, Yen Chou

AU - Shiau, Shoei Yn Lin

PY - 1998

Y1 - 1998

N2 - It has been demonstrated that diets rich in fruits and vegetables are protective aganist cardiovascular diseases and certain forms of cancer. These protective effects have been attributed to the anti-oxidant present, including vitamin C, Carotenes and phytopolyphenols. The polyphenolic components of higher plants may act as anti-oxidants (sometimes may be as pro-oxidants), or as agents of other mechanisms, contributing to the anti-carcinogenic or cadioprotective action. Curcumin is a widely used dietary pigment (curry), and this polyphenolic compound has been demonstrated to be an inhibitor of tumor promotion in chemical carcinogenesis. Recent studies also indicate that tea polyphenols are active in inhibiting the processes of carcinogenesis induced by various carcinogens. Investigations from this laboratory and others have indicated that modulation of mitotic signal transduction may attribute, in part, to the molecular mechanisms of these cancer chemopreventive agents.

AB - It has been demonstrated that diets rich in fruits and vegetables are protective aganist cardiovascular diseases and certain forms of cancer. These protective effects have been attributed to the anti-oxidant present, including vitamin C, Carotenes and phytopolyphenols. The polyphenolic components of higher plants may act as anti-oxidants (sometimes may be as pro-oxidants), or as agents of other mechanisms, contributing to the anti-carcinogenic or cadioprotective action. Curcumin is a widely used dietary pigment (curry), and this polyphenolic compound has been demonstrated to be an inhibitor of tumor promotion in chemical carcinogenesis. Recent studies also indicate that tea polyphenols are active in inhibiting the processes of carcinogenesis induced by various carcinogens. Investigations from this laboratory and others have indicated that modulation of mitotic signal transduction may attribute, in part, to the molecular mechanisms of these cancer chemopreventive agents.

UR - http://www.scopus.com/inward/record.url?scp=0346393974&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0346393974&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0346393974

VL - 701

SP - 225

EP - 238

JO - ACS Symposium Series

JF - ACS Symposium Series

SN - 0097-6156

ER -