Modulation of microsomal cytochrome P450 by Scutellariae Radix and Gentianae Scabrae Radix in rat liver

Jaw Jou Kang, Yi Chien Chen, Wei Chung Kuo, Terri Chen, Yu Wen Cheng, Min Liang Kuo, Tzuu Huei Ueng

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19 Citations (Scopus)

Abstract

The present study has determined the effects of Scutellariae Radix(Huangqin) and Gentianae scabrae Radix (Longdan) on liver microsomal cytochrome P450 (P450)-dependent mono-oxygenases using rats pretreated with crude extracts of medicinal herbs. Scutellariae Radix resulted in a 53% decrease of pentoxyresorufin O-dealkylase activity in liver microsomes. In contrast, Gentianae scabrae Radix caused a 50% increase of benzo(a)pyrene hydroxylase activity. Immunoblotting analysis of liver microsomes revealed that Scutellariae Radix induced and suppressed the levels of P450 1A and 2B proteins, respectively. Scutellariae and Gentianae scabrae Radixes had no effects on microsomal aniline hydroxylase activity and P450 2E1 protein.

Original languageEnglish
Pages (from-to)19-29
Number of pages11
JournalAmerican Journal of Chinese Medicine
Volume24
Issue number1
Publication statusPublished - 1996
Externally publishedYes

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ASJC Scopus subject areas

  • Complementary and alternative medicine

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