Modulation of microsomal cytochrome P450 by Scutellariae Radix and Gentianae Scabrae Radix in rat liver

Jaw Jou Kang, Yi Chien Chen, Wei Chung Kuo, Terri Chen, Yu Wen Cheng, Min Liang Kuo, Tzuu Huei Ueng

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The present study has determined the effects of Scutellariae Radix(Huangqin) and Gentianae scabrae Radix (Longdan) on liver microsomal cytochrome P450 (P450)-dependent mono-oxygenases using rats pretreated with crude extracts of medicinal herbs. Scutellariae Radix resulted in a 53% decrease of pentoxyresorufin O-dealkylase activity in liver microsomes. In contrast, Gentianae scabrae Radix caused a 50% increase of benzo(a)pyrene hydroxylase activity. Immunoblotting analysis of liver microsomes revealed that Scutellariae Radix induced and suppressed the levels of P450 1A and 2B proteins, respectively. Scutellariae and Gentianae scabrae Radixes had no effects on microsomal aniline hydroxylase activity and P450 2E1 protein.

Original languageEnglish
Pages (from-to)19-29
Number of pages11
JournalAmerican Journal of Chinese Medicine
Volume24
Issue number1
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

Scutellaria baicalensis
Cytochrome P-450 Enzyme System
Liver
Liver Microsomes
Scutellaria
Benzopyrene Hydroxylase
Aniline Hydroxylase
Cytochrome P-450 CYP2B1
Oxygenases
Medicinal Plants
Complex Mixtures
Immunoblotting
Proteins

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Modulation of microsomal cytochrome P450 by Scutellariae Radix and Gentianae Scabrae Radix in rat liver. / Kang, Jaw Jou; Chen, Yi Chien; Kuo, Wei Chung; Chen, Terri; Cheng, Yu Wen; Kuo, Min Liang; Ueng, Tzuu Huei.

In: American Journal of Chinese Medicine, Vol. 24, No. 1, 1996, p. 19-29.

Research output: Contribution to journalArticle

Kang, Jaw Jou ; Chen, Yi Chien ; Kuo, Wei Chung ; Chen, Terri ; Cheng, Yu Wen ; Kuo, Min Liang ; Ueng, Tzuu Huei. / Modulation of microsomal cytochrome P450 by Scutellariae Radix and Gentianae Scabrae Radix in rat liver. In: American Journal of Chinese Medicine. 1996 ; Vol. 24, No. 1. pp. 19-29.
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AU - Cheng, Yu Wen

AU - Kuo, Min Liang

AU - Ueng, Tzuu Huei

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