飲食成份對細胞色素P450的影響

Translated title of the contribution: Modulation of cytochrome P450s by dietary components

Y. H. Chen, Y. W. Lee, J. F. Liu

Research output: Contribution to journalArticle

Abstract

Xenobiotic metabolizing enzymes are involved in the biotransformation of lipophilic xenobiotics, including carcinogens, into more polar metabolites for excretion. Cytochrome P450 (CYP)-dependent monooxygenases are a family of phase I xenobiotic metabolizing enzymes that introduce a functional group such as -OH into the substrate. Some CYPs are inducible by various chemicals, such as polycyclic aromatic hydrocarbons, phenobarbital and ethanol etc.. In addition, the expression of CYPs can also be modulated by various physiological conditions, nutrients and dietary components, including obesity, fasting, carbohydrate, protein, fat, vitamins, minerals, organosulfur compounds, polyphenols and food additives. Therefore, the nutritional status and the xenobiotic metabolizing system are closely associated. In this review, their relationship is discussed.

Original languageTraditional Chinese
Pages (from-to)1-10
Number of pages10
JournalNutritional Sciences Journal
Volume26
Issue number1
Publication statusPublished - 2001

Fingerprint

Xenobiotics
Cytochromes
xenobiotics
cytochromes
organic sulfur compounds
Food Additives
phenobarbital
Polycyclic Aromatic Hydrocarbons
food additives
Polyphenols
carcinogens
Enzymes
polycyclic aromatic hydrocarbons
Phenobarbital
Biotransformation
enzymes
Mixed Function Oxygenases
biotransformation
Nutritional Status
cytochrome P-450

Keywords

  • Cytochrome P450
  • Dietary components
  • Nutrient
  • Xenobiotic metabolizing enzyme

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

飲食成份對細胞色素P450的影響. / Chen, Y. H.; Lee, Y. W.; Liu, J. F.

In: Nutritional Sciences Journal, Vol. 26, No. 1, 2001, p. 1-10.

Research output: Contribution to journalArticle

Chen, YH, Lee, YW & Liu, JF 2001, '飲食成份對細胞色素P450的影響', Nutritional Sciences Journal, vol. 26, no. 1, pp. 1-10.
Chen, Y. H. ; Lee, Y. W. ; Liu, J. F. / 飲食成份對細胞色素P450的影響. In: Nutritional Sciences Journal. 2001 ; Vol. 26, No. 1. pp. 1-10.
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KW - 營養素

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