Modulating inhibitory control with direct current stimulation of the superior medial frontal cortex

Tzu Yu Hsu, Lin Yuan Tseng, Jia Xin Yu, Wen Jui Kuo, Daisy L. Hung, Ovid J L Tzeng, Vincent Walsh, Neil G. Muggleton, Chi Hung Juan

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

The executive control of voluntary action involves not only choosing from a range of possible actions but also the inhibition of responses as circumstances demand. Recent studies have demonstrated that many clinical populations, such as people with attention-deficit hyperactivity disorder, exhibit difficulties in inhibitory control. One prefrontal area that has been particularly associated with inhibitory control is the pre-supplementary motor area (Pre-SMA). Here we applied non-invasive transcranial direct current stimulation (tDCS) over Pre-SMA to test its role in this behavior. tDCS allows for current to be applied in two directions to selectively excite or suppress the neural activity of Pre-SMA. Our results showed that anodal tDCS improved efficiency of inhibitory control. Conversely, cathodal tDCS showed a tendency towards impaired inhibitory control. To our knowledge, this is the first demonstration of non-invasive intervention tDCS altering subjects' inhibitory control. These results further our understanding of the neural bases of inhibitory control and suggest a possible therapeutic intervention method for clinical populations.

Original languageEnglish
Pages (from-to)2249-2257
Number of pages9
JournalNeuroImage
Volume56
Issue number4
DOIs
Publication statusPublished - Jun 15 2011
Externally publishedYes

Fingerprint

Frontal Lobe
Motor Cortex
Executive Function
Attention Deficit Disorder with Hyperactivity
Population
Transcranial Direct Current Stimulation
Efficiency

Keywords

  • Inhibitory control
  • Pre-SMA
  • Stop signal task
  • TDCS

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Hsu, T. Y., Tseng, L. Y., Yu, J. X., Kuo, W. J., Hung, D. L., Tzeng, O. J. L., ... Juan, C. H. (2011). Modulating inhibitory control with direct current stimulation of the superior medial frontal cortex. NeuroImage, 56(4), 2249-2257. https://doi.org/10.1016/j.neuroimage.2011.03.059

Modulating inhibitory control with direct current stimulation of the superior medial frontal cortex. / Hsu, Tzu Yu; Tseng, Lin Yuan; Yu, Jia Xin; Kuo, Wen Jui; Hung, Daisy L.; Tzeng, Ovid J L; Walsh, Vincent; Muggleton, Neil G.; Juan, Chi Hung.

In: NeuroImage, Vol. 56, No. 4, 15.06.2011, p. 2249-2257.

Research output: Contribution to journalArticle

Hsu, TY, Tseng, LY, Yu, JX, Kuo, WJ, Hung, DL, Tzeng, OJL, Walsh, V, Muggleton, NG & Juan, CH 2011, 'Modulating inhibitory control with direct current stimulation of the superior medial frontal cortex', NeuroImage, vol. 56, no. 4, pp. 2249-2257. https://doi.org/10.1016/j.neuroimage.2011.03.059
Hsu, Tzu Yu ; Tseng, Lin Yuan ; Yu, Jia Xin ; Kuo, Wen Jui ; Hung, Daisy L. ; Tzeng, Ovid J L ; Walsh, Vincent ; Muggleton, Neil G. ; Juan, Chi Hung. / Modulating inhibitory control with direct current stimulation of the superior medial frontal cortex. In: NeuroImage. 2011 ; Vol. 56, No. 4. pp. 2249-2257.
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