Mismatch negativity to the patient's own name in chronic disorders of consciousness

Pengmin Qin, Haibo Di, Xiaodan Yan, Senming Yu, Dan Yu, Steven Laureys, Xuchu Weng

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Previous studies implicated potential value of mismatch negativity (MMN) in predicting recovery of consciousness in patients with disorders of consciousness (DOC). We have adopted a novel MMN evoked by subject's own name (SON), a self-referential stimulus thought to be powerful in evoking residual brain activity, and examined the correlation between the MMN and recovery of consciousness in patients with chronic (>1 month) DOC. Twelve patients and 12 age-matched healthy controls were investigated. The patients were diagnosed as coma (n = 4), vegetative state (VS, n = 6), and minimally conscious state (MCS, n = 2), mainly based on the JFK Coma Recovery Scale-Revised. The SON-evoked MMN (SON-MMN) was present in seven patients. Critically, the presence of SON-MMN was significantly correlated with recovery of consciousness. While four of the five patients (three VS and two coma) showing SON-MMN changed to MCS 3 months later, the rest of the patients (three VS and two coma) without SON-MMN failed to show any clinical improvement. Our study thus illustrates that the subject's own name is effective in evoking MMN in patients with DOC, and that SON-MMN has potential prognostic values in predicting recovery of consciousness. © 2008 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)24-28
Number of pages5
JournalNeuroscience Letters
Volume448
Issue number1
DOIs
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

Consciousness Disorders
Names
Coma
Consciousness
Persistent Vegetative State
Ireland

Keywords

  • Disorders of consciousness
  • Minimally conscious state
  • Mismatch negativity
  • Own name
  • Vegetative state
  • adolescent
  • adult
  • article
  • chronic disease
  • clinical article
  • coma
  • consciousness disorder
  • controlled study
  • convalescence
  • electroencephalogram
  • event related potential
  • female
  • Glasgow coma scale
  • human
  • jfk coma recovery scale
  • male
  • minimally conscious state
  • mismatch negativity
  • persistent vegetative state
  • prediction
  • priority journal
  • prognosis
  • psychologic assessment
  • rating scale
  • self evaluation
  • Acoustic Stimulation
  • Adolescent
  • Adult
  • Auditory Perception
  • Case-Control Studies
  • Chronic Disease
  • Consciousness Disorders
  • Contingent Negative Variation
  • Electroencephalography
  • Evoked Potentials, Auditory
  • Female
  • Follow-Up Studies
  • Glasgow Coma Scale
  • Humans
  • Male
  • Middle Aged
  • Names

Cite this

Mismatch negativity to the patient's own name in chronic disorders of consciousness. / Qin, Pengmin; Di, Haibo; Yan, Xiaodan; Yu, Senming; Yu, Dan; Laureys, Steven; Weng, Xuchu.

In: Neuroscience Letters, Vol. 448, No. 1, 2008, p. 24-28.

Research output: Contribution to journalArticle

Qin, Pengmin ; Di, Haibo ; Yan, Xiaodan ; Yu, Senming ; Yu, Dan ; Laureys, Steven ; Weng, Xuchu. / Mismatch negativity to the patient's own name in chronic disorders of consciousness. In: Neuroscience Letters. 2008 ; Vol. 448, No. 1. pp. 24-28.
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abstract = "Previous studies implicated potential value of mismatch negativity (MMN) in predicting recovery of consciousness in patients with disorders of consciousness (DOC). We have adopted a novel MMN evoked by subject's own name (SON), a self-referential stimulus thought to be powerful in evoking residual brain activity, and examined the correlation between the MMN and recovery of consciousness in patients with chronic (>1 month) DOC. Twelve patients and 12 age-matched healthy controls were investigated. The patients were diagnosed as coma (n = 4), vegetative state (VS, n = 6), and minimally conscious state (MCS, n = 2), mainly based on the JFK Coma Recovery Scale-Revised. The SON-evoked MMN (SON-MMN) was present in seven patients. Critically, the presence of SON-MMN was significantly correlated with recovery of consciousness. While four of the five patients (three VS and two coma) showing SON-MMN changed to MCS 3 months later, the rest of the patients (three VS and two coma) without SON-MMN failed to show any clinical improvement. Our study thus illustrates that the subject's own name is effective in evoking MMN in patients with DOC, and that SON-MMN has potential prognostic values in predicting recovery of consciousness. {\circledC} 2008 Elsevier Ireland Ltd. All rights reserved.",
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author = "Pengmin Qin and Haibo Di and Xiaodan Yan and Senming Yu and Dan Yu and Steven Laureys and Xuchu Weng",
note = "被引用次數:52 Export Date: 31 March 2016 CODEN: NELED 通訊地址: Weng, X.; Laboratory for Higher Brain Functions, Institute of Psychology, Chinese Academy of Sciences, 4A, Datun Road, Chaoyang District, Beijing, 100101, China; 電子郵件: wengxc@psych.ac.cn 參考文獻: Beauchemin, M., De Beaumont, L., Vannasing, P., Turcotte, A., Arcand, C., Belin, P., Lassonde, M., Electrophysiological markers of voice familiarity (2006) Eur. J. Neurosci., 23, pp. 3081-3086; Born, J.D., Albert, A., Hans, P., Bonnal, J., Relative prognostic value of best motor response and brain stem reflexes in patients with severe head injury (1985) Neurosurgery, 16, pp. 595-601; Daltrozzo, J., Wioland, N., Mutschler, V., Kotchoubey, B., Predicting coma and other low responsive patients outcome using event-related brain potentials: a meta-analysis (2007) Clin. Neurophysiol., 118, pp. 606-614; Di, H.B., Yu, S.M., Weng, X.C., Laureys, S., Yu, D., Li, J.Q., Qin, P.M., Chen, Y.Z., Cerebral response to patient's own name in the vegetative and minimally conscious states (2007) Neurology, 68, pp. 895-899; Fischer, C., Morlet, D., Bouchet, P., Luaute, J., Jourdan, C., Salord, F., Mismatch negativity and late auditory evoked potentials in comatose patients (1999) Clin. Neurophysiol., 110, pp. 1601-1610; Giacino, J.T., Kalmar, K., Whyte, J., The JFK coma recovery scale-revised: measurement characteristics and diagnostic utility (2004) Arch. Phys. Med. Rehabil., 85, pp. 2020-2029; Goydke, K.N., Altenmuller, E., Moller, J., Munte, T.F., Changes in emotional tone and instrumental timbre are reflected by the mismatch negativity (2004) Brain Res. Cogn. Brain Res., 21, pp. 351-359; Holeckova, I., Fischer, C., Giard, M.H., Delpuech, C., Morlet, D., Brain responses to a subject's own name uttered by a familiar voice (2006) Brain. Res., 1082, pp. 142-152; Jacobsen, T., Horvath, J., Schroger, E., Lattner, S., Widmann, A., Winkler, I., Pre-attentive auditory processing of lexicality (2004) Brain Language, 88, pp. 54-67; Jacobsen, T., Schroger, E., Measuring duration mismatch negativity (2003) Clin. Neurophysiol., 114, pp. 1133-1143; Kotchoubey, B., Lang, S., Herb, E., Maurer, P., Birbaumer, N., Reliability of brain responses to the own name in healthy subjects and patients with brain damage (2004) Brainwaves and Mind: Recent Advances, pp. 75-80. , Moore N.C., and Arikan M.K. (Eds), Kjellberg, Inc., New York; Kotchoubey, B., Lang, S., Herb, E., Maurer, P., Schmalohr, D., Bostanov, V., Birbaumer, N., Stimulus complexity enhances auditory discrimination in patients with extremely severe brain injuries (2003) Neurosci. Lett., 352, pp. 129-132; Kotchoubey, B., Lang, S., Mezger, G., Schmalohr, D., Schneck, M., Semmler, A., Bostanov, V., Birbaumer, N., Information processing in severe disorders of consciousness: vegetative state and minimally conscious state (2005) Clin. Neurophysiol., 116, pp. 2441-2453; Laureys, S., Perrin, F., Bredart, S., Self-consciousness in non-communicative patients (2007) Conscious. Cogn., 16, pp. 722-741; Laureys, S., Perrin, F., Faymonville, M.E., Schnakers, C., Boly, M., Bartsch, V., Majerus, S., Maquet, P., Cerebral processing in the minimally conscious state (2004) Neurology, 63, pp. 916-918; Mazzini, L., Zaccala, M., Gareri, F., Giordano, A., Angelino, E., Long-latency auditory-evoked potentials in severe traumatic brain injury (2001) Arch. Phys. Med. Rehabil., 82, pp. 57-65; Naatanen, R., Paavilainen, P., Rinne, T., Alho, K., The mismatch negativity (MMN) in basic research of central auditory processing: a review (2007) Clin. Neurophysiol., 118, pp. 2544-2590; Perrin, F., Schnakers, C., Schabus, M., Degueldre, C., Goldman, S., Bredart, S., Faymonville, M.E., Laureys, S., Brain response to one's own name in vegetative state, minimally conscious state, and locked-in syndrome (2006) Arch. Neurol., 63, pp. 562-569; Roye, A., Jacobsen, T., Schroger, E., Personal significance is encoded automatically by the human brain: an event-related potential study with ringtones (2007) Eur. J. Neurosci., 26, pp. 784-790; Semlitsch, H.V., Anderer, P., Schuster, P., Presslich, O., A solution for reliable and valid reduction of ocular artifacts, applied to the P300 ERP (1986) Psychophysiology, 23, pp. 695-703; Signorino, M., D'Acunto, S., Angeleri, F., Pietropaoli, P., Eliciting P300 in comatose patients (1995) Lancet, 345, pp. 255-256; Staffen, W., Kronbichler, M., Aichhorn, M., Mair, A., Ladurner, G., Selective brain activity in response to one's own name in the persistent vegetative state (2006) J. Neurol. Neurosurg. Psychiatry, 77, pp. 1383-1384; Takegata, R., Brattico, E., Tervaniemi, M., Varyagina, O., Naatanen, R., Winkler, I., Preattentive representation of feature conjunctions for concurrent spatially distributed auditory objects (2005) Brain Res. Cogn. Brain Res., 25, pp. 169-179; Teasdale, G., Jennett, B., Assessment of coma and impaired consciousness. A practical scale (1974) Lancet, 2, pp. 81-84; Wijnen, V.J., van Boxtel, G.J., Eilander, H.J., de Gelder, B., Mismatch negativity predicts recovery from the vegetative state (2007) Clin. Neurophysiol., 118, pp. 597-605",
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pages = "24--28",
journal = "Neuroscience Letters",
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publisher = "Elsevier Ireland Ltd",
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TY - JOUR

T1 - Mismatch negativity to the patient's own name in chronic disorders of consciousness

AU - Qin, Pengmin

AU - Di, Haibo

AU - Yan, Xiaodan

AU - Yu, Senming

AU - Yu, Dan

AU - Laureys, Steven

AU - Weng, Xuchu

N1 - 被引用次數:52 Export Date: 31 March 2016 CODEN: NELED 通訊地址: Weng, X.; Laboratory for Higher Brain Functions, Institute of Psychology, Chinese Academy of Sciences, 4A, Datun Road, Chaoyang District, Beijing, 100101, China; 電子郵件: wengxc@psych.ac.cn 參考文獻: Beauchemin, M., De Beaumont, L., Vannasing, P., Turcotte, A., Arcand, C., Belin, P., Lassonde, M., Electrophysiological markers of voice familiarity (2006) Eur. J. Neurosci., 23, pp. 3081-3086; Born, J.D., Albert, A., Hans, P., Bonnal, J., Relative prognostic value of best motor response and brain stem reflexes in patients with severe head injury (1985) Neurosurgery, 16, pp. 595-601; Daltrozzo, J., Wioland, N., Mutschler, V., Kotchoubey, B., Predicting coma and other low responsive patients outcome using event-related brain potentials: a meta-analysis (2007) Clin. Neurophysiol., 118, pp. 606-614; Di, H.B., Yu, S.M., Weng, X.C., Laureys, S., Yu, D., Li, J.Q., Qin, P.M., Chen, Y.Z., Cerebral response to patient's own name in the vegetative and minimally conscious states (2007) Neurology, 68, pp. 895-899; Fischer, C., Morlet, D., Bouchet, P., Luaute, J., Jourdan, C., Salord, F., Mismatch negativity and late auditory evoked potentials in comatose patients (1999) Clin. Neurophysiol., 110, pp. 1601-1610; Giacino, J.T., Kalmar, K., Whyte, J., The JFK coma recovery scale-revised: measurement characteristics and diagnostic utility (2004) Arch. Phys. Med. Rehabil., 85, pp. 2020-2029; Goydke, K.N., Altenmuller, E., Moller, J., Munte, T.F., Changes in emotional tone and instrumental timbre are reflected by the mismatch negativity (2004) Brain Res. Cogn. Brain Res., 21, pp. 351-359; Holeckova, I., Fischer, C., Giard, M.H., Delpuech, C., Morlet, D., Brain responses to a subject's own name uttered by a familiar voice (2006) Brain. Res., 1082, pp. 142-152; Jacobsen, T., Horvath, J., Schroger, E., Lattner, S., Widmann, A., Winkler, I., Pre-attentive auditory processing of lexicality (2004) Brain Language, 88, pp. 54-67; Jacobsen, T., Schroger, E., Measuring duration mismatch negativity (2003) Clin. Neurophysiol., 114, pp. 1133-1143; Kotchoubey, B., Lang, S., Herb, E., Maurer, P., Birbaumer, N., Reliability of brain responses to the own name in healthy subjects and patients with brain damage (2004) Brainwaves and Mind: Recent Advances, pp. 75-80. , Moore N.C., and Arikan M.K. (Eds), Kjellberg, Inc., New York; Kotchoubey, B., Lang, S., Herb, E., Maurer, P., Schmalohr, D., Bostanov, V., Birbaumer, N., Stimulus complexity enhances auditory discrimination in patients with extremely severe brain injuries (2003) Neurosci. Lett., 352, pp. 129-132; Kotchoubey, B., Lang, S., Mezger, G., Schmalohr, D., Schneck, M., Semmler, A., Bostanov, V., Birbaumer, N., Information processing in severe disorders of consciousness: vegetative state and minimally conscious state (2005) Clin. Neurophysiol., 116, pp. 2441-2453; Laureys, S., Perrin, F., Bredart, S., Self-consciousness in non-communicative patients (2007) Conscious. Cogn., 16, pp. 722-741; Laureys, S., Perrin, F., Faymonville, M.E., Schnakers, C., Boly, M., Bartsch, V., Majerus, S., Maquet, P., Cerebral processing in the minimally conscious state (2004) Neurology, 63, pp. 916-918; Mazzini, L., Zaccala, M., Gareri, F., Giordano, A., Angelino, E., Long-latency auditory-evoked potentials in severe traumatic brain injury (2001) Arch. Phys. Med. Rehabil., 82, pp. 57-65; Naatanen, R., Paavilainen, P., Rinne, T., Alho, K., The mismatch negativity (MMN) in basic research of central auditory processing: a review (2007) Clin. Neurophysiol., 118, pp. 2544-2590; Perrin, F., Schnakers, C., Schabus, M., Degueldre, C., Goldman, S., Bredart, S., Faymonville, M.E., Laureys, S., Brain response to one's own name in vegetative state, minimally conscious state, and locked-in syndrome (2006) Arch. Neurol., 63, pp. 562-569; Roye, A., Jacobsen, T., Schroger, E., Personal significance is encoded automatically by the human brain: an event-related potential study with ringtones (2007) Eur. J. Neurosci., 26, pp. 784-790; Semlitsch, H.V., Anderer, P., Schuster, P., Presslich, O., A solution for reliable and valid reduction of ocular artifacts, applied to the P300 ERP (1986) Psychophysiology, 23, pp. 695-703; Signorino, M., D'Acunto, S., Angeleri, F., Pietropaoli, P., Eliciting P300 in comatose patients (1995) Lancet, 345, pp. 255-256; Staffen, W., Kronbichler, M., Aichhorn, M., Mair, A., Ladurner, G., Selective brain activity in response to one's own name in the persistent vegetative state (2006) J. Neurol. Neurosurg. Psychiatry, 77, pp. 1383-1384; Takegata, R., Brattico, E., Tervaniemi, M., Varyagina, O., Naatanen, R., Winkler, I., Preattentive representation of feature conjunctions for concurrent spatially distributed auditory objects (2005) Brain Res. Cogn. Brain Res., 25, pp. 169-179; Teasdale, G., Jennett, B., Assessment of coma and impaired consciousness. A practical scale (1974) Lancet, 2, pp. 81-84; Wijnen, V.J., van Boxtel, G.J., Eilander, H.J., de Gelder, B., Mismatch negativity predicts recovery from the vegetative state (2007) Clin. Neurophysiol., 118, pp. 597-605

PY - 2008

Y1 - 2008

N2 - Previous studies implicated potential value of mismatch negativity (MMN) in predicting recovery of consciousness in patients with disorders of consciousness (DOC). We have adopted a novel MMN evoked by subject's own name (SON), a self-referential stimulus thought to be powerful in evoking residual brain activity, and examined the correlation between the MMN and recovery of consciousness in patients with chronic (>1 month) DOC. Twelve patients and 12 age-matched healthy controls were investigated. The patients were diagnosed as coma (n = 4), vegetative state (VS, n = 6), and minimally conscious state (MCS, n = 2), mainly based on the JFK Coma Recovery Scale-Revised. The SON-evoked MMN (SON-MMN) was present in seven patients. Critically, the presence of SON-MMN was significantly correlated with recovery of consciousness. While four of the five patients (three VS and two coma) showing SON-MMN changed to MCS 3 months later, the rest of the patients (three VS and two coma) without SON-MMN failed to show any clinical improvement. Our study thus illustrates that the subject's own name is effective in evoking MMN in patients with DOC, and that SON-MMN has potential prognostic values in predicting recovery of consciousness. © 2008 Elsevier Ireland Ltd. All rights reserved.

AB - Previous studies implicated potential value of mismatch negativity (MMN) in predicting recovery of consciousness in patients with disorders of consciousness (DOC). We have adopted a novel MMN evoked by subject's own name (SON), a self-referential stimulus thought to be powerful in evoking residual brain activity, and examined the correlation between the MMN and recovery of consciousness in patients with chronic (>1 month) DOC. Twelve patients and 12 age-matched healthy controls were investigated. The patients were diagnosed as coma (n = 4), vegetative state (VS, n = 6), and minimally conscious state (MCS, n = 2), mainly based on the JFK Coma Recovery Scale-Revised. The SON-evoked MMN (SON-MMN) was present in seven patients. Critically, the presence of SON-MMN was significantly correlated with recovery of consciousness. While four of the five patients (three VS and two coma) showing SON-MMN changed to MCS 3 months later, the rest of the patients (three VS and two coma) without SON-MMN failed to show any clinical improvement. Our study thus illustrates that the subject's own name is effective in evoking MMN in patients with DOC, and that SON-MMN has potential prognostic values in predicting recovery of consciousness. © 2008 Elsevier Ireland Ltd. All rights reserved.

KW - Disorders of consciousness

KW - Minimally conscious state

KW - Mismatch negativity

KW - Own name

KW - Vegetative state

KW - adolescent

KW - adult

KW - article

KW - chronic disease

KW - clinical article

KW - coma

KW - consciousness disorder

KW - controlled study

KW - convalescence

KW - electroencephalogram

KW - event related potential

KW - female

KW - Glasgow coma scale

KW - human

KW - jfk coma recovery scale

KW - male

KW - minimally conscious state

KW - mismatch negativity

KW - persistent vegetative state

KW - prediction

KW - priority journal

KW - prognosis

KW - psychologic assessment

KW - rating scale

KW - self evaluation

KW - Acoustic Stimulation

KW - Adolescent

KW - Adult

KW - Auditory Perception

KW - Case-Control Studies

KW - Chronic Disease

KW - Consciousness Disorders

KW - Contingent Negative Variation

KW - Electroencephalography

KW - Evoked Potentials, Auditory

KW - Female

KW - Follow-Up Studies

KW - Glasgow Coma Scale

KW - Humans

KW - Male

KW - Middle Aged

KW - Names

KW - Disorders of consciousness

KW - Vegetative state

KW - Own name

KW - Mismatch negativity

KW - Minimally conscious state

U2 - 10.1016/j.neulet.2008.10.029

DO - 10.1016/j.neulet.2008.10.029

M3 - Article

VL - 448

SP - 24

EP - 28

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

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