Mismatch negativity to the patient's own name in chronic disorders of consciousness

Pengmin Qin, Haibo Di, Xiaodan Yan, Senming Yu, Dan Yu, Steven Laureys, Xuchu Weng

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)

Abstract

Previous studies implicated potential value of mismatch negativity (MMN) in predicting recovery of consciousness in patients with disorders of consciousness (DOC). We have adopted a novel MMN evoked by subject's own name (SON), a self-referential stimulus thought to be powerful in evoking residual brain activity, and examined the correlation between the MMN and recovery of consciousness in patients with chronic (>1 month) DOC. Twelve patients and 12 age-matched healthy controls were investigated. The patients were diagnosed as coma (n = 4), vegetative state (VS, n = 6), and minimally conscious state (MCS, n = 2), mainly based on the JFK Coma Recovery Scale-Revised. The SON-evoked MMN (SON-MMN) was present in seven patients. Critically, the presence of SON-MMN was significantly correlated with recovery of consciousness. While four of the five patients (three VS and two coma) showing SON-MMN changed to MCS 3 months later, the rest of the patients (three VS and two coma) without SON-MMN failed to show any clinical improvement. Our study thus illustrates that the subject's own name is effective in evoking MMN in patients with DOC, and that SON-MMN has potential prognostic values in predicting recovery of consciousness. © 2008 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)24-28
Number of pages5
JournalNeuroscience Letters
Volume448
Issue number1
DOIs
Publication statusPublished - 2008
Externally publishedYes

Keywords

  • Disorders of consciousness
  • Minimally conscious state
  • Mismatch negativity
  • Own name
  • Vegetative state
  • adolescent
  • adult
  • article
  • chronic disease
  • clinical article
  • coma
  • consciousness disorder
  • controlled study
  • convalescence
  • electroencephalogram
  • event related potential
  • female
  • Glasgow coma scale
  • human
  • jfk coma recovery scale
  • male
  • minimally conscious state
  • mismatch negativity
  • persistent vegetative state
  • prediction
  • priority journal
  • prognosis
  • psychologic assessment
  • rating scale
  • self evaluation
  • Acoustic Stimulation
  • Adolescent
  • Adult
  • Auditory Perception
  • Case-Control Studies
  • Chronic Disease
  • Consciousness Disorders
  • Contingent Negative Variation
  • Electroencephalography
  • Evoked Potentials, Auditory
  • Female
  • Follow-Up Studies
  • Glasgow Coma Scale
  • Humans
  • Male
  • Middle Aged
  • Names

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