Mismatch negativity to the patient's own name in chronic disorders of consciousness

Pengmin Qin, Haibo Di, Xiaodan Yan, Senming Yu, Dan Yu, Steven Laureys, Xuchu Weng

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Previous studies implicated potential value of mismatch negativity (MMN) in predicting recovery of consciousness in patients with disorders of consciousness (DOC). We have adopted a novel MMN evoked by subject's own name (SON), a self-referential stimulus thought to be powerful in evoking residual brain activity, and examined the correlation between the MMN and recovery of consciousness in patients with chronic (>1 month) DOC. Twelve patients and 12 age-matched healthy controls were investigated. The patients were diagnosed as coma (n = 4), vegetative state (VS, n = 6), and minimally conscious state (MCS, n = 2), mainly based on the JFK Coma Recovery Scale-Revised. The SON-evoked MMN (SON-MMN) was present in seven patients. Critically, the presence of SON-MMN was significantly correlated with recovery of consciousness. While four of the five patients (three VS and two coma) showing SON-MMN changed to MCS 3 months later, the rest of the patients (three VS and two coma) without SON-MMN failed to show any clinical improvement. Our study thus illustrates that the subject's own name is effective in evoking MMN in patients with DOC, and that SON-MMN has potential prognostic values in predicting recovery of consciousness. © 2008 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)24-28
Number of pages5
JournalNeuroscience Letters
Volume448
Issue number1
DOIs
Publication statusPublished - 2008
Externally publishedYes

    Fingerprint

Keywords

  • Disorders of consciousness
  • Minimally conscious state
  • Mismatch negativity
  • Own name
  • Vegetative state
  • adolescent
  • adult
  • article
  • chronic disease
  • clinical article
  • coma
  • consciousness disorder
  • controlled study
  • convalescence
  • electroencephalogram
  • event related potential
  • female
  • Glasgow coma scale
  • human
  • jfk coma recovery scale
  • male
  • minimally conscious state
  • mismatch negativity
  • persistent vegetative state
  • prediction
  • priority journal
  • prognosis
  • psychologic assessment
  • rating scale
  • self evaluation
  • Acoustic Stimulation
  • Adolescent
  • Adult
  • Auditory Perception
  • Case-Control Studies
  • Chronic Disease
  • Consciousness Disorders
  • Contingent Negative Variation
  • Electroencephalography
  • Evoked Potentials, Auditory
  • Female
  • Follow-Up Studies
  • Glasgow Coma Scale
  • Humans
  • Male
  • Middle Aged
  • Names

Cite this