Abstract
MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.
| Original language | English |
|---|---|
| Journal | Nucleic Acids Research |
| Volume | 42 |
| Issue number | D1 |
| DOIs | |
| Publication status | Published - Jan 1 2014 |
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ASJC Scopus subject areas
- Genetics
- Medicine(all)
Cite this
MiRTarBase update 2014 : An information resource for experimentally validated miRNA-target interactions. / Hsu, Sheng Da; Tseng, Yu Ting; Shrestha, Sirjana; Lin, Yu Ling; Khaleel, Anas; Chou, Chih Hung; Chu, Chao Fang; Huang, Hsi Yuan; Lin, Ching Min; Ho, Shu Yi; Jian, Ting Yan; Lin, Feng Mao; Chang, Tzu Hao; Weng, Shun Long; Liao, Kuang Wen; Liao, I. En; Liu, Chun Chi; Huang, Hsien Da.
In: Nucleic Acids Research, Vol. 42, No. D1, 01.01.2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - MiRTarBase update 2014
T2 - An information resource for experimentally validated miRNA-target interactions
AU - Hsu, Sheng Da
AU - Tseng, Yu Ting
AU - Shrestha, Sirjana
AU - Lin, Yu Ling
AU - Khaleel, Anas
AU - Chou, Chih Hung
AU - Chu, Chao Fang
AU - Huang, Hsi Yuan
AU - Lin, Ching Min
AU - Ho, Shu Yi
AU - Jian, Ting Yan
AU - Lin, Feng Mao
AU - Chang, Tzu Hao
AU - Weng, Shun Long
AU - Liao, Kuang Wen
AU - Liao, I. En
AU - Liu, Chun Chi
AU - Huang, Hsien Da
PY - 2014/1/1
Y1 - 2014/1/1
N2 - MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.
AB - MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.
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U2 - 10.1093/nar/gkt1266
DO - 10.1093/nar/gkt1266
M3 - Article
VL - 42
JO - Nucleic Acids Research
JF - Nucleic Acids Research
SN - 0305-1048
IS - D1
ER -