MiRTarBase update 2014: An information resource for experimentally validated miRNA-target interactions

Sheng Da Hsu; Yu Ting Tseng; Sirjana Shrestha; Yu Ling Lin; Anas Khaleel; Chih Hung Chou; Chao Fang Chu; Hsi Yuan Huang; Ching Min Lin; Shu Yi Ho; Ting Yan Jian; Feng Mao Lin; Tzu Hao Chang; Shun Long Weng; Kuang Wen Liao; I. En Liao; Chun Chi Liu; Hsien Da Huang

doi:10.1093/nar/gkt1266

MiRTarBase update 2014: An information resource for experimentally validated miRNA-target interactions

Sheng Da Hsu, Yu Ting Tseng, Sirjana Shrestha, Yu Ling Lin, Anas Khaleel, Chih Hung Chou, Chao Fang Chu, Hsi Yuan Huang, Ching Min Lin, Shu Yi Ho, Ting Yan Jian, Feng Mao Lin, Tzu Hao Chang, Shun Long Weng, Kuang Wen Liao, I. En Liao, Chun Chi Liu, Hsien Da Huang

Research output: Contribution to journal › Article

514 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.

Original language	English
Journal	Nucleic Acids Research
Volume	42
Issue number	D1
DOIs	https://doi.org/10.1093/nar/gkt1266
Publication status	Published - Jan 1 2014

Fingerprint

ASJC Scopus subject areas

Genetics
Medicine(all)

Cite this

Hsu, S. D., Tseng, Y. T., Shrestha, S., Lin, Y. L., Khaleel, A., Chou, C. H., Chu, C. F., Huang, H. Y., Lin, C. M., Ho, S. Y., Jian, T. Y., Lin, F. M., Chang, T. H., Weng, S. L., Liao, K. W., Liao, I. E., Liu, C. C., & Huang, H. D. (2014). MiRTarBase update 2014: An information resource for experimentally validated miRNA-target interactions. Nucleic Acids Research, 42(D1). https://doi.org/10.1093/nar/gkt1266

MiRTarBase update 2014 : An information resource for experimentally validated miRNA-target interactions. / Hsu, Sheng Da; Tseng, Yu Ting; Shrestha, Sirjana; Lin, Yu Ling; Khaleel, Anas; Chou, Chih Hung; Chu, Chao Fang; Huang, Hsi Yuan; Lin, Ching Min; Ho, Shu Yi; Jian, Ting Yan; Lin, Feng Mao; Chang, Tzu Hao; Weng, Shun Long; Liao, Kuang Wen; Liao, I. En; Liu, Chun Chi; Huang, Hsien Da.

In: Nucleic Acids Research, Vol. 42, No. D1, 01.01.2014.

Research output: Contribution to journal › Article

Hsu, Sheng Da ; Tseng, Yu Ting ; Shrestha, Sirjana ; Lin, Yu Ling ; Khaleel, Anas ; Chou, Chih Hung ; Chu, Chao Fang ; Huang, Hsi Yuan ; Lin, Ching Min ; Ho, Shu Yi ; Jian, Ting Yan ; Lin, Feng Mao ; Chang, Tzu Hao ; Weng, Shun Long ; Liao, Kuang Wen ; Liao, I. En ; Liu, Chun Chi ; Huang, Hsien Da. / MiRTarBase update 2014 : An information resource for experimentally validated miRNA-target interactions. In: Nucleic Acids Research. 2014 ; Vol. 42, No. D1.

@article{36c94910975f46059c13373493a960b9,

title = "MiRTarBase update 2014: An information resource for experimentally validated miRNA-target interactions",

abstract = "MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.",

author = "Hsu, {Sheng Da} and Tseng, {Yu Ting} and Sirjana Shrestha and Lin, {Yu Ling} and Anas Khaleel and Chou, {Chih Hung} and Chu, {Chao Fang} and Huang, {Hsi Yuan} and Lin, {Ching Min} and Ho, {Shu Yi} and Jian, {Ting Yan} and Lin, {Feng Mao} and Chang, {Tzu Hao} and Weng, {Shun Long} and Liao, {Kuang Wen} and Liao, {I. En} and Liu, {Chun Chi} and Huang, {Hsien Da}",

year = "2014",

month = jan

day = "1",

doi = "10.1093/nar/gkt1266",

language = "English",

volume = "42",

journal = "Nucleic Acids Research",

issn = "0305-1048",

publisher = "Oxford University Press",

number = "D1",

}

TY - JOUR

T1 - MiRTarBase update 2014

T2 - An information resource for experimentally validated miRNA-target interactions

AU - Hsu, Sheng Da

AU - Tseng, Yu Ting

AU - Shrestha, Sirjana

AU - Lin, Yu Ling

AU - Khaleel, Anas

AU - Chou, Chih Hung

AU - Chu, Chao Fang

AU - Huang, Hsi Yuan

AU - Lin, Ching Min

AU - Ho, Shu Yi

AU - Jian, Ting Yan

AU - Lin, Feng Mao

AU - Chang, Tzu Hao

AU - Weng, Shun Long

AU - Liao, Kuang Wen

AU - Liao, I. En

AU - Liu, Chun Chi

AU - Huang, Hsien Da

PY - 2014/1/1

Y1 - 2014/1/1

N2 - MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.

AB - MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.

UR - http://www.scopus.com/inward/record.url?scp=84891796290&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891796290&partnerID=8YFLogxK

U2 - 10.1093/nar/gkt1266

DO - 10.1093/nar/gkt1266

M3 - Article

C2 - 24304892

AN - SCOPUS:84891796290

VL - 42

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - D1

ER -

Access to Document

10.1093/nar/gkt1266