MiRTarBase update 2014: An information resource for experimentally validated miRNA-target interactions

Sheng Da Hsu, Yu Ting Tseng, Sirjana Shrestha, Yu Ling Lin, Anas Khaleel, Chih Hung Chou, Chao Fang Chu, Hsi Yuan Huang, Ching Min Lin, Shu Yi Ho, Ting Yan Jian, Feng Mao Lin, Tzu Hao Chang, Shun Long Weng, Kuang Wen Liao, I. En Liao, Chun Chi Liu, Hsien Da Huang

Research output: Contribution to journalArticle

527 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.

Original languageEnglish
JournalNucleic Acids Research
Volume42
Issue numberD1
DOIs
Publication statusPublished - Jan 1 2014

ASJC Scopus subject areas

  • Genetics
  • Medicine(all)

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    Hsu, S. D., Tseng, Y. T., Shrestha, S., Lin, Y. L., Khaleel, A., Chou, C. H., Chu, C. F., Huang, H. Y., Lin, C. M., Ho, S. Y., Jian, T. Y., Lin, F. M., Chang, T. H., Weng, S. L., Liao, K. W., Liao, I. E., Liu, C. C., & Huang, H. D. (2014). MiRTarBase update 2014: An information resource for experimentally validated miRNA-target interactions. Nucleic Acids Research, 42(D1). https://doi.org/10.1093/nar/gkt1266