miR-145 mediates the anti-cancer stemness effect of photodynamic therapy with 5-aminolevulinic acid (ALA) in oral cancer cells

Chih Yuan Fang, Pei Yin Chen, Dennis Chun Yu Ho, Lo Lin Tsai, Pei Ling Hsieh, Ming Yi Lu, Cheng Chia Yu, Chuan Hang Yu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

5-Aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) has been used in the treatment of various precancerous and malignant lesions. Our previous work has demonstrated that ALA-PDT possesses the potential to serve as an adjuvant therapy against head and neck cancer via eliminating the cancer stem cells (CSCs) property. This study aimed to further investigate the possible molecular mechanism underlying the effect of ALA-PDT. Our results revealed that ALA-PDT upregulated the expression of microRNA-145 (miR-145) in two oral cancer cell lines. Overexpression of miR-145 in oral CSCs further enhanced the treatment effect of ALA-PDT with lower self-renewal, invasion capacities and reduced CD44 expression, while inhibition of miR-145 exhibited the opposite phenomena. These findings suggest that the anti-CSCs effect of ALA-PDT is due to an elevation of miR-145.

Original languageEnglish
Pages (from-to)738-742
Number of pages5
JournalJournal of the Formosan Medical Association
Volume117
Issue number8
DOIs
Publication statusPublished - Aug 1 2018

Keywords

  • 5-Aminolevulinic acid-mediated photodynamic therapy
  • microRNA-145
  • Oral cancer stem cells

ASJC Scopus subject areas

  • Medicine(all)

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