Midtrimester maternal serum inhibin A levels after multifetal pregnancy reduction

Heng J. Chen, Lee W. Huang, Yu Hung Lin, Kok M. Seow, Bih Chwen Hsieh, Jiann-Loung Hwang, Chii Ruey Tzeng

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Abstract

Objective: To investigate the relationship between the maternal serum inhibin A concentrations and the number of fetuses. Further, the maternal serum inhibin A levels for twin pregnancies and multiple pregnancies reduced to twins in the second trimester were compared. Methods: Three groups of women with pregnancies following in vitro fertilization and embryo transfer were recruited for this study. Groups 1, 2 and 3 included 20 singleton pregnancies, 37 twin pregnancies, and 35 multifetal pregnancies, respectively. In group 3, multifetal reduction was performed during 10-12 weeks of gestation. Blood samples were obtained longitudinally at 10th, 12th, 15th and 18th week of gestation. Results: There was a significant association between the number of fetuses and maternal plasma inhibin A prior to multifetal reduction. The inhibin A levels were not significantly different between twin and multifetal reduced twin pregnancies at 15th and 18th weeks of gestation. Conclusion: In multifetal reduction to twin pregnancies, the maternal serum levels of inhibin A decrease to the level of twin pregnancies during the second trimester. Therefore, inhibin A may be effectively used as a marker for Down syndrome screening in cases of twin pregnancy following multifetal reduction.

Original languageEnglish
Pages (from-to)431-434
Number of pages4
JournalPrenatal Diagnosis
Volume27
Issue number5
DOIs
Publication statusPublished - May 2007

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Keywords

  • Down syndrome screening
  • Inhibin A
  • Multifetal reduction
  • Second-trimester pregnancy

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynaecology

Cite this

Chen, H. J., Huang, L. W., Lin, Y. H., Seow, K. M., Hsieh, B. C., Hwang, J-L., & Tzeng, C. R. (2007). Midtrimester maternal serum inhibin A levels after multifetal pregnancy reduction. Prenatal Diagnosis, 27(5), 431-434. https://doi.org/10.1002/pd.1702