Microstructural white matter tissue characteristics are modulated by homocysteine: A diffusion tensor imaging study

Rong-Long Shiu, Wei Hung Chen, Chyi Huey Bai, Jyu Gang Leu, Chien-Yeh Hsu, Max A. Viergever, Alexander Leemans

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5 Citations (Scopus)


Homocysteine level can lead to adverse effects on the brain white matter through endothelial dysfunction, microstructural inflammation, and neurotoxin effects. Despite previously observed associations between elevated homocysteine and macroscopic structural brain changes, it is still unknown whether microstructural associations of homocysteine on brain tissue properties can be observed in healthy subjects with routine MRI. To this end, we investigated potential relationships between homocysteine levels and microstructural measures computed with diffusion tensor imaging (DTI) in a cohort of 338 healthy participants. Significant positive correlations were observed between homocysteine levels and diffusivity measures in the bilateral temporalWM, the brainstem, and the bilateral cerebellar peduncle. This is the first study demonstrating that DTI is sufficiently sensitive to relate microstructural WM properties to homocysteine levels in healthy subjects.

Original languageEnglish
Article numbere0116330
JournalPLoS One
Issue number2
Publication statusPublished - Feb 18 2015


ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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