Microstructural white matter tissue characteristics are modulated by homocysteine

A diffusion tensor imaging study

Rong-Long Shiu, Wei Hung Chen, Chyi Huey Bai, Jyu Gang Leu, Chien-Yeh Hsu, Max A. Viergever, Alexander Leemans

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Homocysteine level can lead to adverse effects on the brain white matter through endothelial dysfunction, microstructural inflammation, and neurotoxin effects. Despite previously observed associations between elevated homocysteine and macroscopic structural brain changes, it is still unknown whether microstructural associations of homocysteine on brain tissue properties can be observed in healthy subjects with routine MRI. To this end, we investigated potential relationships between homocysteine levels and microstructural measures computed with diffusion tensor imaging (DTI) in a cohort of 338 healthy participants. Significant positive correlations were observed between homocysteine levels and diffusivity measures in the bilateral temporalWM, the brainstem, and the bilateral cerebellar peduncle. This is the first study demonstrating that DTI is sufficiently sensitive to relate microstructural WM properties to homocysteine levels in healthy subjects.

Original languageEnglish
Article numbere0116330
JournalPLoS One
Volume10
Issue number2
DOIs
Publication statusPublished - Feb 18 2015

Fingerprint

Diffusion tensor imaging
Diffusion Tensor Imaging
homocysteine
Homocysteine
image analysis
Tissue
Brain
Healthy Volunteers
brain
neurotoxins
Neurotoxins
brain stem
peduncle
diffusivity
Magnetic resonance imaging
Brain Stem
White Matter
tissues
inflammation
adverse effects

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Microstructural white matter tissue characteristics are modulated by homocysteine : A diffusion tensor imaging study. / Shiu, Rong-Long; Chen, Wei Hung; Bai, Chyi Huey; Leu, Jyu Gang; Hsu, Chien-Yeh; Viergever, Max A.; Leemans, Alexander.

In: PLoS One, Vol. 10, No. 2, e0116330, 18.02.2015.

Research output: Contribution to journalArticle

Shiu, Rong-Long ; Chen, Wei Hung ; Bai, Chyi Huey ; Leu, Jyu Gang ; Hsu, Chien-Yeh ; Viergever, Max A. ; Leemans, Alexander. / Microstructural white matter tissue characteristics are modulated by homocysteine : A diffusion tensor imaging study. In: PLoS One. 2015 ; Vol. 10, No. 2.
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