Microsatellite instability is associated with a better prognosis for gastric cancer patients after curative surgery

Wen Liang Fang, Shih Ching Chang, Yuan Tzu Lan, Kuo Hung Huang, Jen Hao Chen, Su Shun Lo, Mao Chih Hsieh, Anna Fen Yau Li, Chew Wun Wu, Shih Hwa Chiou

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background Microsatellite instability (MSI) is one of the leading mechanisms for the carcinogenesis of gastric cancer. Its prognostic value is controversial. Methods Between May 1988 and Oct 2003, a total of 214 gastric cancer patients undergoing curative surgery were enrolled, and their MSI statuses were classified as MSI-H (high) or MSI-L/S (low/stable). The clinicopathologic characteristics of MSI-H and MSI-L/S gastric cancers were compared. Results The MSI-Htumors accounted for 11.7 %(n = 25) of the 214 total gastric cancers. Although not statistically significant, the MSI-H gastric cancers were more frequently located in the lower third of the stomach (64 % vs. 49.2 %) and were more often the intestinal type (72 % vs. 61.4 %) compared to the MSI-L/S gastric cancers. The MSI-Hgastric cancers had a significantly better 5-year overall survival (OS) rate (68 % vs. 47.6 %, p = 0.030) and a trend of a better 3-year disease-free survival rate (71.8 % vs. 55.2 %, p = 0.076) compared to the MSI-L/S gastric cancers. A multivariate analysis revealed that pathologic TNM stage and MSI status were the independent prognostic factors for OS after curative surgery. Conclusions Compared to MSI-L/S tumors, MSI-H tumors are associated with a better OS rate for gastric cancer patients after R0 resection.

Original languageEnglish
Pages (from-to)2131-2138
Number of pages8
JournalWorld Journal of Surgery
Volume36
Issue number9
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Microsatellite Instability
Stomach Neoplasms
Survival Rate
Neoplasms
Disease-Free Survival

ASJC Scopus subject areas

  • Surgery

Cite this

Fang, W. L., Chang, S. C., Lan, Y. T., Huang, K. H., Chen, J. H., Lo, S. S., ... Chiou, S. H. (2012). Microsatellite instability is associated with a better prognosis for gastric cancer patients after curative surgery. World Journal of Surgery, 36(9), 2131-2138. https://doi.org/10.1007/s00268-012-1652-7

Microsatellite instability is associated with a better prognosis for gastric cancer patients after curative surgery. / Fang, Wen Liang; Chang, Shih Ching; Lan, Yuan Tzu; Huang, Kuo Hung; Chen, Jen Hao; Lo, Su Shun; Hsieh, Mao Chih; Li, Anna Fen Yau; Wu, Chew Wun; Chiou, Shih Hwa.

In: World Journal of Surgery, Vol. 36, No. 9, 09.2012, p. 2131-2138.

Research output: Contribution to journalArticle

Fang, WL, Chang, SC, Lan, YT, Huang, KH, Chen, JH, Lo, SS, Hsieh, MC, Li, AFY, Wu, CW & Chiou, SH 2012, 'Microsatellite instability is associated with a better prognosis for gastric cancer patients after curative surgery', World Journal of Surgery, vol. 36, no. 9, pp. 2131-2138. https://doi.org/10.1007/s00268-012-1652-7
Fang, Wen Liang ; Chang, Shih Ching ; Lan, Yuan Tzu ; Huang, Kuo Hung ; Chen, Jen Hao ; Lo, Su Shun ; Hsieh, Mao Chih ; Li, Anna Fen Yau ; Wu, Chew Wun ; Chiou, Shih Hwa. / Microsatellite instability is associated with a better prognosis for gastric cancer patients after curative surgery. In: World Journal of Surgery. 2012 ; Vol. 36, No. 9. pp. 2131-2138.
@article{74a282621cf34ac0a421f8756051e4b9,
title = "Microsatellite instability is associated with a better prognosis for gastric cancer patients after curative surgery",
abstract = "Background Microsatellite instability (MSI) is one of the leading mechanisms for the carcinogenesis of gastric cancer. Its prognostic value is controversial. Methods Between May 1988 and Oct 2003, a total of 214 gastric cancer patients undergoing curative surgery were enrolled, and their MSI statuses were classified as MSI-H (high) or MSI-L/S (low/stable). The clinicopathologic characteristics of MSI-H and MSI-L/S gastric cancers were compared. Results The MSI-Htumors accounted for 11.7 {\%}(n = 25) of the 214 total gastric cancers. Although not statistically significant, the MSI-H gastric cancers were more frequently located in the lower third of the stomach (64 {\%} vs. 49.2 {\%}) and were more often the intestinal type (72 {\%} vs. 61.4 {\%}) compared to the MSI-L/S gastric cancers. The MSI-Hgastric cancers had a significantly better 5-year overall survival (OS) rate (68 {\%} vs. 47.6 {\%}, p = 0.030) and a trend of a better 3-year disease-free survival rate (71.8 {\%} vs. 55.2 {\%}, p = 0.076) compared to the MSI-L/S gastric cancers. A multivariate analysis revealed that pathologic TNM stage and MSI status were the independent prognostic factors for OS after curative surgery. Conclusions Compared to MSI-L/S tumors, MSI-H tumors are associated with a better OS rate for gastric cancer patients after R0 resection.",
author = "Fang, {Wen Liang} and Chang, {Shih Ching} and Lan, {Yuan Tzu} and Huang, {Kuo Hung} and Chen, {Jen Hao} and Lo, {Su Shun} and Hsieh, {Mao Chih} and Li, {Anna Fen Yau} and Wu, {Chew Wun} and Chiou, {Shih Hwa}",
year = "2012",
month = "9",
doi = "10.1007/s00268-012-1652-7",
language = "English",
volume = "36",
pages = "2131--2138",
journal = "World Journal of Surgery",
issn = "0364-2313",
publisher = "Springer New York LLC",
number = "9",

}

TY - JOUR

T1 - Microsatellite instability is associated with a better prognosis for gastric cancer patients after curative surgery

AU - Fang, Wen Liang

AU - Chang, Shih Ching

AU - Lan, Yuan Tzu

AU - Huang, Kuo Hung

AU - Chen, Jen Hao

AU - Lo, Su Shun

AU - Hsieh, Mao Chih

AU - Li, Anna Fen Yau

AU - Wu, Chew Wun

AU - Chiou, Shih Hwa

PY - 2012/9

Y1 - 2012/9

N2 - Background Microsatellite instability (MSI) is one of the leading mechanisms for the carcinogenesis of gastric cancer. Its prognostic value is controversial. Methods Between May 1988 and Oct 2003, a total of 214 gastric cancer patients undergoing curative surgery were enrolled, and their MSI statuses were classified as MSI-H (high) or MSI-L/S (low/stable). The clinicopathologic characteristics of MSI-H and MSI-L/S gastric cancers were compared. Results The MSI-Htumors accounted for 11.7 %(n = 25) of the 214 total gastric cancers. Although not statistically significant, the MSI-H gastric cancers were more frequently located in the lower third of the stomach (64 % vs. 49.2 %) and were more often the intestinal type (72 % vs. 61.4 %) compared to the MSI-L/S gastric cancers. The MSI-Hgastric cancers had a significantly better 5-year overall survival (OS) rate (68 % vs. 47.6 %, p = 0.030) and a trend of a better 3-year disease-free survival rate (71.8 % vs. 55.2 %, p = 0.076) compared to the MSI-L/S gastric cancers. A multivariate analysis revealed that pathologic TNM stage and MSI status were the independent prognostic factors for OS after curative surgery. Conclusions Compared to MSI-L/S tumors, MSI-H tumors are associated with a better OS rate for gastric cancer patients after R0 resection.

AB - Background Microsatellite instability (MSI) is one of the leading mechanisms for the carcinogenesis of gastric cancer. Its prognostic value is controversial. Methods Between May 1988 and Oct 2003, a total of 214 gastric cancer patients undergoing curative surgery were enrolled, and their MSI statuses were classified as MSI-H (high) or MSI-L/S (low/stable). The clinicopathologic characteristics of MSI-H and MSI-L/S gastric cancers were compared. Results The MSI-Htumors accounted for 11.7 %(n = 25) of the 214 total gastric cancers. Although not statistically significant, the MSI-H gastric cancers were more frequently located in the lower third of the stomach (64 % vs. 49.2 %) and were more often the intestinal type (72 % vs. 61.4 %) compared to the MSI-L/S gastric cancers. The MSI-Hgastric cancers had a significantly better 5-year overall survival (OS) rate (68 % vs. 47.6 %, p = 0.030) and a trend of a better 3-year disease-free survival rate (71.8 % vs. 55.2 %, p = 0.076) compared to the MSI-L/S gastric cancers. A multivariate analysis revealed that pathologic TNM stage and MSI status were the independent prognostic factors for OS after curative surgery. Conclusions Compared to MSI-L/S tumors, MSI-H tumors are associated with a better OS rate for gastric cancer patients after R0 resection.

UR - http://www.scopus.com/inward/record.url?scp=84867843715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867843715&partnerID=8YFLogxK

U2 - 10.1007/s00268-012-1652-7

DO - 10.1007/s00268-012-1652-7

M3 - Article

VL - 36

SP - 2131

EP - 2138

JO - World Journal of Surgery

JF - World Journal of Surgery

SN - 0364-2313

IS - 9

ER -