Abstract
Background Microsatellite instability (MSI) is one of the leading mechanisms for the carcinogenesis of gastric cancer. Its prognostic value is controversial. Methods Between May 1988 and Oct 2003, a total of 214 gastric cancer patients undergoing curative surgery were enrolled, and their MSI statuses were classified as MSI-H (high) or MSI-L/S (low/stable). The clinicopathologic characteristics of MSI-H and MSI-L/S gastric cancers were compared. Results The MSI-Htumors accounted for 11.7 %(n = 25) of the 214 total gastric cancers. Although not statistically significant, the MSI-H gastric cancers were more frequently located in the lower third of the stomach (64 % vs. 49.2 %) and were more often the intestinal type (72 % vs. 61.4 %) compared to the MSI-L/S gastric cancers. The MSI-Hgastric cancers had a significantly better 5-year overall survival (OS) rate (68 % vs. 47.6 %, p = 0.030) and a trend of a better 3-year disease-free survival rate (71.8 % vs. 55.2 %, p = 0.076) compared to the MSI-L/S gastric cancers. A multivariate analysis revealed that pathologic TNM stage and MSI status were the independent prognostic factors for OS after curative surgery. Conclusions Compared to MSI-L/S tumors, MSI-H tumors are associated with a better OS rate for gastric cancer patients after R0 resection.
| Original language | English |
|---|---|
| Pages (from-to) | 2131-2138 |
| Number of pages | 8 |
| Journal | World Journal of Surgery |
| Volume | 36 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2012 |
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ASJC Scopus subject areas
- Surgery
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Microsatellite instability is associated with a better prognosis for gastric cancer patients after curative surgery. / Fang, Wen Liang; Chang, Shih Ching; Lan, Yuan Tzu; Huang, Kuo Hung; Chen, Jen Hao; Lo, Su Shun; Hsieh, Mao Chih; Li, Anna Fen Yau; Wu, Chew Wun; Chiou, Shih Hwa.
In: World Journal of Surgery, Vol. 36, No. 9, 09.2012, p. 2131-2138.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Microsatellite instability is associated with a better prognosis for gastric cancer patients after curative surgery
AU - Fang, Wen Liang
AU - Chang, Shih Ching
AU - Lan, Yuan Tzu
AU - Huang, Kuo Hung
AU - Chen, Jen Hao
AU - Lo, Su Shun
AU - Hsieh, Mao Chih
AU - Li, Anna Fen Yau
AU - Wu, Chew Wun
AU - Chiou, Shih Hwa
PY - 2012/9
Y1 - 2012/9
N2 - Background Microsatellite instability (MSI) is one of the leading mechanisms for the carcinogenesis of gastric cancer. Its prognostic value is controversial. Methods Between May 1988 and Oct 2003, a total of 214 gastric cancer patients undergoing curative surgery were enrolled, and their MSI statuses were classified as MSI-H (high) or MSI-L/S (low/stable). The clinicopathologic characteristics of MSI-H and MSI-L/S gastric cancers were compared. Results The MSI-Htumors accounted for 11.7 %(n = 25) of the 214 total gastric cancers. Although not statistically significant, the MSI-H gastric cancers were more frequently located in the lower third of the stomach (64 % vs. 49.2 %) and were more often the intestinal type (72 % vs. 61.4 %) compared to the MSI-L/S gastric cancers. The MSI-Hgastric cancers had a significantly better 5-year overall survival (OS) rate (68 % vs. 47.6 %, p = 0.030) and a trend of a better 3-year disease-free survival rate (71.8 % vs. 55.2 %, p = 0.076) compared to the MSI-L/S gastric cancers. A multivariate analysis revealed that pathologic TNM stage and MSI status were the independent prognostic factors for OS after curative surgery. Conclusions Compared to MSI-L/S tumors, MSI-H tumors are associated with a better OS rate for gastric cancer patients after R0 resection.
AB - Background Microsatellite instability (MSI) is one of the leading mechanisms for the carcinogenesis of gastric cancer. Its prognostic value is controversial. Methods Between May 1988 and Oct 2003, a total of 214 gastric cancer patients undergoing curative surgery were enrolled, and their MSI statuses were classified as MSI-H (high) or MSI-L/S (low/stable). The clinicopathologic characteristics of MSI-H and MSI-L/S gastric cancers were compared. Results The MSI-Htumors accounted for 11.7 %(n = 25) of the 214 total gastric cancers. Although not statistically significant, the MSI-H gastric cancers were more frequently located in the lower third of the stomach (64 % vs. 49.2 %) and were more often the intestinal type (72 % vs. 61.4 %) compared to the MSI-L/S gastric cancers. The MSI-Hgastric cancers had a significantly better 5-year overall survival (OS) rate (68 % vs. 47.6 %, p = 0.030) and a trend of a better 3-year disease-free survival rate (71.8 % vs. 55.2 %, p = 0.076) compared to the MSI-L/S gastric cancers. A multivariate analysis revealed that pathologic TNM stage and MSI status were the independent prognostic factors for OS after curative surgery. Conclusions Compared to MSI-L/S tumors, MSI-H tumors are associated with a better OS rate for gastric cancer patients after R0 resection.
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U2 - 10.1007/s00268-012-1652-7
DO - 10.1007/s00268-012-1652-7
M3 - Article
C2 - 22669398
AN - SCOPUS:84867843715
VL - 36
SP - 2131
EP - 2138
JO - World Journal of Surgery
JF - World Journal of Surgery
SN - 0364-2313
IS - 9
ER -