MicroRNAs in atherosclerosis

Ku Chung Chen, Suh Hang Hank Juo

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

MicroRNAs are endogenously expressed small noncoding RNAs that regulate gene expression at the post-transcriptional level. MicroRNAs have emerged as key regulators of several physiological and pathophysiological processes in the cardiovascular system. Aberrant expression of microRNAs has been implicated in the pathophysiological processes underlying the development of atherosclerosis and cardiovascular disease, including change in endothelial function, vascular smooth muscle cell proliferation and migration, macrophage function, and foam cell formation. In this review, we summarize the recent data showing the roles of microRNAs in cell studies, studies on atherosclerotic mice, and human studies.

Original languageEnglish
Pages (from-to)631-640
Number of pages10
JournalKaohsiung Journal of Medical Sciences
Volume28
Issue number12
DOIs
Publication statusPublished - Dec 2012
Externally publishedYes

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Keywords

  • Atherosclerosis
  • Cardiovascular disease
  • MicroRNA

ASJC Scopus subject areas

  • Medicine(all)

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