MicroRNA in lung cancer

P. Y. Lin, S. L. Yu, P. C. Yang

Research output: Contribution to journalShort surveypeer-review

178 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small non-protein-coding RNAs that function as endogenous negative gene regulators. Dysfunctions of miRNAs are frequently found in malignancies, including lung cancer. In this review, we summarise the current understanding of miRNAs in lung cancer tumourigenesis, and highlight their potential in overcoming drug resistance, abetting histological sub-classification techniques, and serving as biomarkers for lung cancer risk stratification and outcome prediction.

Original languageEnglish
Pages (from-to)1144-1148
Number of pages5
JournalBritish Journal of Cancer
Volume103
Issue number8
DOIs
Publication statusPublished - Oct 12 2010

Keywords

  • lung cancer
  • microRNA
  • oncogene
  • personalised medicine
  • risk stratification
  • tumour suppressor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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