MicroRNA expression profiling in PBMCs: A potential diagnostic biomarker of chronic hepatitis C

Chiu Chun Chang, Chun Che Lin, Wan Ling Hsieh, Hsin Wu Lai, Chia Hsun Tsai, Ya Wen Cheng

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Abstract

The expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 in PBMCs were significantly higher in CHC patients compared with healthy controls and significantly different between CHC patients with HCV genotype 1 (GT-1) and non-genotype-1 (non-GT-1). Multivariate logistic regression analysis also showed that patients with high expression levels of the six target miRNAs had an approximately 7.202-fold risk of CHC compared with those with low expression levels of the target miRNAs. We concluded that the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC.

Original languageEnglish
Article number367157
JournalDisease Markers
Volume2014
DOIs
Publication statusPublished - 2014

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ASJC Scopus subject areas

  • Biochemistry, medical
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Chang, C. C., Lin, C. C., Hsieh, W. L., Lai, H. W., Tsai, C. H., & Cheng, Y. W. (2014). MicroRNA expression profiling in PBMCs: A potential diagnostic biomarker of chronic hepatitis C. Disease Markers, 2014, [367157]. https://doi.org/10.1155/2014/367157