MicroRNA-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through nuclear factor kappa B pathways

Lisheng Zhang, Lixin Yang, Xiyong Liu, Wei Chen, Lufen Chang, Linling Chen, Sofia Loera, Peiguo Chu, Wei Chien Huang, Yun Ru Liu, Yun Yen

Research output: Contribution to journalArticle

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Abstract

Growing evidence indicates that deregulation of microRNAs (miRNAs) contributes to tumorigenesis. Dysregulation of miR-657 has been observed in several types of cancers, but its biological function is still largely unknown. Our results showed that miR-657 expression can be induced by hepatitis viral proteins and is significantly increased in hepatocellular carcinoma (HCC) tissues. Moreover, introduction of miR-657 dramatically increases proliferation and colony formation of HCC cells in vitro and induces tumor development in immunodeficient mice. Further studies showed that miR-657 directly targets the transducin-like enhancer protein 1 (TLE1) 3′ untranslated region (UTR) and activates nuclear factor kappa B (NF-κB) pathways that contribute to hepatocarcinogenesis. Conclusion: This study identified a mechanism whereby miRNA-657 contributed to HCC through novel cancer pathways and provides new insights into the potential molecular mechanisms of hepatic carcinogenesis. (HEPATOLOGY 2013)

Original languageEnglish
Pages (from-to)1919-1930
Number of pages12
JournalHepatology
Volume57
Issue number5
DOIs
Publication statusPublished - May 1 2013

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Transducin
NF-kappa B
MicroRNAs
Hepatocellular Carcinoma
Carcinogenesis
Neoplasms
Proteins
3' Untranslated Regions
Viral Proteins
Hepatitis
Liver

ASJC Scopus subject areas

  • Hepatology

Cite this

MicroRNA-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through nuclear factor kappa B pathways. / Zhang, Lisheng; Yang, Lixin; Liu, Xiyong; Chen, Wei; Chang, Lufen; Chen, Linling; Loera, Sofia; Chu, Peiguo; Huang, Wei Chien; Liu, Yun Ru; Yen, Yun.

In: Hepatology, Vol. 57, No. 5, 01.05.2013, p. 1919-1930.

Research output: Contribution to journalArticle

Zhang, Lisheng ; Yang, Lixin ; Liu, Xiyong ; Chen, Wei ; Chang, Lufen ; Chen, Linling ; Loera, Sofia ; Chu, Peiguo ; Huang, Wei Chien ; Liu, Yun Ru ; Yen, Yun. / MicroRNA-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through nuclear factor kappa B pathways. In: Hepatology. 2013 ; Vol. 57, No. 5. pp. 1919-1930.
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AU - Chen, Linling

AU - Loera, Sofia

AU - Chu, Peiguo

AU - Huang, Wei Chien

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