Abstract
Objective: Lycopene is an antioxidant that reduces oxidative stress. Analgesics are commonly used and may impair kidney function. However, the associations among plasma lycopene, analgesic use, and chronic kidney disease (CKD) are unknown. A hospital-based, case-control study was conducted to determine the association among plasma lycopene, analgesic use, and CKD. Methods: Two hundred one patients with CKD and 313 controls were recruited, and CKD was defined as an estimated glomerular filtration rate 2, as calculated by the Modification of Diet in Renal Disease formula. Plasma antioxidants were measured by high-performance liquid chromatography. Results: This study showed that the higher the plasma lycopene was, the lower the CKD risk. Specifically, in subjects with a plasma lycopene level ≥17.97 or 7.72-17.97 μg/dL, the adjusted odds ratio of CKD was 0.32 (95% confidence interval 0.18-0.58) or 0.49 (95% confidence interval 0.29-0.83), respectively, compared with subjects with a plasma lycopene level
| Original language | English |
|---|---|
| Pages (from-to) | 276-282 |
| Number of pages | 7 |
| Journal | Nutrition |
| Volume | 26 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2010 |
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Keywords
- Analgesics
- Chronic kidney disease
- Lycopene
- Micronutrients
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics
Cite this
Micronutrients and lifestyles in Taiwanese patients with stage 3 to 5 chronic kidney disease. / Chiang, Shou Shan; Tai, Cheng Wei; Chung, Chi Jung; Shiue, Horng Sheng; Chen, Jin Bor; Su, Chien-Tien; Hsueh, Yu-Mei.
In: Nutrition, Vol. 26, No. 3, 03.2010, p. 276-282.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Micronutrients and lifestyles in Taiwanese patients with stage 3 to 5 chronic kidney disease
AU - Chiang, Shou Shan
AU - Tai, Cheng Wei
AU - Chung, Chi Jung
AU - Shiue, Horng Sheng
AU - Chen, Jin Bor
AU - Su, Chien-Tien
AU - Hsueh, Yu-Mei
PY - 2010/3
Y1 - 2010/3
N2 - Objective: Lycopene is an antioxidant that reduces oxidative stress. Analgesics are commonly used and may impair kidney function. However, the associations among plasma lycopene, analgesic use, and chronic kidney disease (CKD) are unknown. A hospital-based, case-control study was conducted to determine the association among plasma lycopene, analgesic use, and CKD. Methods: Two hundred one patients with CKD and 313 controls were recruited, and CKD was defined as an estimated glomerular filtration rate 2, as calculated by the Modification of Diet in Renal Disease formula. Plasma antioxidants were measured by high-performance liquid chromatography. Results: This study showed that the higher the plasma lycopene was, the lower the CKD risk. Specifically, in subjects with a plasma lycopene level ≥17.97 or 7.72-17.97 μg/dL, the adjusted odds ratio of CKD was 0.32 (95% confidence interval 0.18-0.58) or 0.49 (95% confidence interval 0.29-0.83), respectively, compared with subjects with a plasma lycopene level
AB - Objective: Lycopene is an antioxidant that reduces oxidative stress. Analgesics are commonly used and may impair kidney function. However, the associations among plasma lycopene, analgesic use, and chronic kidney disease (CKD) are unknown. A hospital-based, case-control study was conducted to determine the association among plasma lycopene, analgesic use, and CKD. Methods: Two hundred one patients with CKD and 313 controls were recruited, and CKD was defined as an estimated glomerular filtration rate 2, as calculated by the Modification of Diet in Renal Disease formula. Plasma antioxidants were measured by high-performance liquid chromatography. Results: This study showed that the higher the plasma lycopene was, the lower the CKD risk. Specifically, in subjects with a plasma lycopene level ≥17.97 or 7.72-17.97 μg/dL, the adjusted odds ratio of CKD was 0.32 (95% confidence interval 0.18-0.58) or 0.49 (95% confidence interval 0.29-0.83), respectively, compared with subjects with a plasma lycopene level
KW - Analgesics
KW - Chronic kidney disease
KW - Lycopene
KW - Micronutrients
UR - http://www.scopus.com/inward/record.url?scp=75949092997&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75949092997&partnerID=8YFLogxK
U2 - 10.1016/j.nut.2009.04.021
DO - 10.1016/j.nut.2009.04.021
M3 - Article
VL - 26
SP - 276
EP - 282
JO - Nutrition
JF - Nutrition
SN - 0899-9007
IS - 3
ER -