TY - JOUR
T1 - Micronutrients and lifestyles in Taiwanese patients with stage 3 to 5 chronic kidney disease
AU - Chiang, Shou Shan
AU - Tai, Cheng Wei
AU - Chung, Chi Jung
AU - Shiue, Horng Sheng
AU - Chen, Jin Bor
AU - Su, Chien-Tien
AU - Hsueh, Yu-Mei
N1 - Funding Information:
The study was supported by grant SKH-TMU-95-23 from Shin Kong Wu Ho-Su Memorial Hospital and Taipei Medical University in Taipei, Taiwan.
Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/3
Y1 - 2010/3
N2 - Objective: Lycopene is an antioxidant that reduces oxidative stress. Analgesics are commonly used and may impair kidney function. However, the associations among plasma lycopene, analgesic use, and chronic kidney disease (CKD) are unknown. A hospital-based, case-control study was conducted to determine the association among plasma lycopene, analgesic use, and CKD. Methods: Two hundred one patients with CKD and 313 controls were recruited, and CKD was defined as an estimated glomerular filtration rate 2, as calculated by the Modification of Diet in Renal Disease formula. Plasma antioxidants were measured by high-performance liquid chromatography. Results: This study showed that the higher the plasma lycopene was, the lower the CKD risk. Specifically, in subjects with a plasma lycopene level ≥17.97 or 7.72-17.97 μg/dL, the adjusted odds ratio of CKD was 0.32 (95% confidence interval 0.18-0.58) or 0.49 (95% confidence interval 0.29-0.83), respectively, compared with subjects with a plasma lycopene level
AB - Objective: Lycopene is an antioxidant that reduces oxidative stress. Analgesics are commonly used and may impair kidney function. However, the associations among plasma lycopene, analgesic use, and chronic kidney disease (CKD) are unknown. A hospital-based, case-control study was conducted to determine the association among plasma lycopene, analgesic use, and CKD. Methods: Two hundred one patients with CKD and 313 controls were recruited, and CKD was defined as an estimated glomerular filtration rate 2, as calculated by the Modification of Diet in Renal Disease formula. Plasma antioxidants were measured by high-performance liquid chromatography. Results: This study showed that the higher the plasma lycopene was, the lower the CKD risk. Specifically, in subjects with a plasma lycopene level ≥17.97 or 7.72-17.97 μg/dL, the adjusted odds ratio of CKD was 0.32 (95% confidence interval 0.18-0.58) or 0.49 (95% confidence interval 0.29-0.83), respectively, compared with subjects with a plasma lycopene level
KW - Analgesics
KW - Chronic kidney disease
KW - Lycopene
KW - Micronutrients
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U2 - 10.1016/j.nut.2009.04.021
DO - 10.1016/j.nut.2009.04.021
M3 - Article
C2 - 19819111
AN - SCOPUS:75949092997
VL - 26
SP - 276
EP - 282
JO - Nutrition
JF - Nutrition
SN - 0899-9007
IS - 3
ER -
