Micronuclei and nuclear anomalies in urinary exfoliated cells of subjects in radionuclide-contaminated regions

Min Hua Jen, Jeng Jong Hwang, Jao Yeh Yang, Yuriy B. Nabyvanets, Wanhwa A. Hsieh, Mon Hsung Tsai, Shin Diau Guo, Wushou P. Chang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

137Cs contamination in living or agricultural environments may contribute to significant human internal exposure and cause adverse health effects. Contamination by 137Cs and other radionuclides was detected in a river valley in northern Taiwan, in the 1990s. Given that the radioactivity appeared to be widely distributed in soil, rice and several other food plants in the areas surrounding several communities in the late 1990s [Y.B. Nabyvanents, T.F. Gesell, M.H. Jen, W.P. Chang, Distribution of 137Cs in soil along Ta-han River Valley in Tau-Yuan County in Taiwan, J. Environ. Radioact. 54 (2001) 391], its possible impact on local occupants was further studied. Ten subjects in three families residing continuously in the highly contaminated valley and 10 non-exposed subjects matched for age, sex, and cigarette smoking habits from neighboring communities were evaluated for micronucleus frequencies and for degenerative nuclear changes in urinary exfoliated epithelial cells (EE cells). Micronucleus frequencies (‰) were significantly higher in the exposed subjects (4.79±1.21‰) than in the reference subjects (2.73±0.59‰; Wilcoxon 2-sample test, P value 0.0004). There were also higher frequencies of EE cells with karyolysis and condensed chromatin in the exposed subjects than in reference subjects. These results indicate that genotoxic and/or mutagenic effects on urinary epithelial cells occur in human subjects who have resided for a long time in a radioactively contaminated environment.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume520
Issue number1-2
DOIs
Publication statusPublished - Sep 26 2002
Externally publishedYes

Fingerprint

Radioisotopes
Epithelial Cells
Taiwan
Rivers
Soil
Edible Plants
Radioactivity
Habits
Chromatin
Smoking
Health
Environ
Oryza

Keywords

  • Cs
  • Exfoliated cells
  • Human
  • Urine

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Genetics

Cite this

Micronuclei and nuclear anomalies in urinary exfoliated cells of subjects in radionuclide-contaminated regions. / Jen, Min Hua; Hwang, Jeng Jong; Yang, Jao Yeh; Nabyvanets, Yuriy B.; Hsieh, Wanhwa A.; Tsai, Mon Hsung; Guo, Shin Diau; Chang, Wushou P.

In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Vol. 520, No. 1-2, 26.09.2002, p. 39-46.

Research output: Contribution to journalArticle

Jen, Min Hua ; Hwang, Jeng Jong ; Yang, Jao Yeh ; Nabyvanets, Yuriy B. ; Hsieh, Wanhwa A. ; Tsai, Mon Hsung ; Guo, Shin Diau ; Chang, Wushou P. / Micronuclei and nuclear anomalies in urinary exfoliated cells of subjects in radionuclide-contaminated regions. In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 2002 ; Vol. 520, No. 1-2. pp. 39-46.
@article{f28365c93cd54e70b1711154a8895ffa,
title = "Micronuclei and nuclear anomalies in urinary exfoliated cells of subjects in radionuclide-contaminated regions",
abstract = "137Cs contamination in living or agricultural environments may contribute to significant human internal exposure and cause adverse health effects. Contamination by 137Cs and other radionuclides was detected in a river valley in northern Taiwan, in the 1990s. Given that the radioactivity appeared to be widely distributed in soil, rice and several other food plants in the areas surrounding several communities in the late 1990s [Y.B. Nabyvanents, T.F. Gesell, M.H. Jen, W.P. Chang, Distribution of 137Cs in soil along Ta-han River Valley in Tau-Yuan County in Taiwan, J. Environ. Radioact. 54 (2001) 391], its possible impact on local occupants was further studied. Ten subjects in three families residing continuously in the highly contaminated valley and 10 non-exposed subjects matched for age, sex, and cigarette smoking habits from neighboring communities were evaluated for micronucleus frequencies and for degenerative nuclear changes in urinary exfoliated epithelial cells (EE cells). Micronucleus frequencies (‰) were significantly higher in the exposed subjects (4.79±1.21‰) than in the reference subjects (2.73±0.59‰; Wilcoxon 2-sample test, P value 0.0004). There were also higher frequencies of EE cells with karyolysis and condensed chromatin in the exposed subjects than in reference subjects. These results indicate that genotoxic and/or mutagenic effects on urinary epithelial cells occur in human subjects who have resided for a long time in a radioactively contaminated environment.",
keywords = "Cs, Exfoliated cells, Human, Urine",
author = "Jen, {Min Hua} and Hwang, {Jeng Jong} and Yang, {Jao Yeh} and Nabyvanets, {Yuriy B.} and Hsieh, {Wanhwa A.} and Tsai, {Mon Hsung} and Guo, {Shin Diau} and Chang, {Wushou P.}",
year = "2002",
month = "9",
day = "26",
doi = "10.1016/S1383-5718(02)00177-8",
language = "English",
volume = "520",
pages = "39--46",
journal = "Mutation Research - Genetic Toxicology and Environmental Mutagenesis",
issn = "1383-5718",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Micronuclei and nuclear anomalies in urinary exfoliated cells of subjects in radionuclide-contaminated regions

AU - Jen, Min Hua

AU - Hwang, Jeng Jong

AU - Yang, Jao Yeh

AU - Nabyvanets, Yuriy B.

AU - Hsieh, Wanhwa A.

AU - Tsai, Mon Hsung

AU - Guo, Shin Diau

AU - Chang, Wushou P.

PY - 2002/9/26

Y1 - 2002/9/26

N2 - 137Cs contamination in living or agricultural environments may contribute to significant human internal exposure and cause adverse health effects. Contamination by 137Cs and other radionuclides was detected in a river valley in northern Taiwan, in the 1990s. Given that the radioactivity appeared to be widely distributed in soil, rice and several other food plants in the areas surrounding several communities in the late 1990s [Y.B. Nabyvanents, T.F. Gesell, M.H. Jen, W.P. Chang, Distribution of 137Cs in soil along Ta-han River Valley in Tau-Yuan County in Taiwan, J. Environ. Radioact. 54 (2001) 391], its possible impact on local occupants was further studied. Ten subjects in three families residing continuously in the highly contaminated valley and 10 non-exposed subjects matched for age, sex, and cigarette smoking habits from neighboring communities were evaluated for micronucleus frequencies and for degenerative nuclear changes in urinary exfoliated epithelial cells (EE cells). Micronucleus frequencies (‰) were significantly higher in the exposed subjects (4.79±1.21‰) than in the reference subjects (2.73±0.59‰; Wilcoxon 2-sample test, P value 0.0004). There were also higher frequencies of EE cells with karyolysis and condensed chromatin in the exposed subjects than in reference subjects. These results indicate that genotoxic and/or mutagenic effects on urinary epithelial cells occur in human subjects who have resided for a long time in a radioactively contaminated environment.

AB - 137Cs contamination in living or agricultural environments may contribute to significant human internal exposure and cause adverse health effects. Contamination by 137Cs and other radionuclides was detected in a river valley in northern Taiwan, in the 1990s. Given that the radioactivity appeared to be widely distributed in soil, rice and several other food plants in the areas surrounding several communities in the late 1990s [Y.B. Nabyvanents, T.F. Gesell, M.H. Jen, W.P. Chang, Distribution of 137Cs in soil along Ta-han River Valley in Tau-Yuan County in Taiwan, J. Environ. Radioact. 54 (2001) 391], its possible impact on local occupants was further studied. Ten subjects in three families residing continuously in the highly contaminated valley and 10 non-exposed subjects matched for age, sex, and cigarette smoking habits from neighboring communities were evaluated for micronucleus frequencies and for degenerative nuclear changes in urinary exfoliated epithelial cells (EE cells). Micronucleus frequencies (‰) were significantly higher in the exposed subjects (4.79±1.21‰) than in the reference subjects (2.73±0.59‰; Wilcoxon 2-sample test, P value 0.0004). There were also higher frequencies of EE cells with karyolysis and condensed chromatin in the exposed subjects than in reference subjects. These results indicate that genotoxic and/or mutagenic effects on urinary epithelial cells occur in human subjects who have resided for a long time in a radioactively contaminated environment.

KW - Cs

KW - Exfoliated cells

KW - Human

KW - Urine

UR - http://www.scopus.com/inward/record.url?scp=0037179505&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037179505&partnerID=8YFLogxK

U2 - 10.1016/S1383-5718(02)00177-8

DO - 10.1016/S1383-5718(02)00177-8

M3 - Article

C2 - 12297142

AN - SCOPUS:0037179505

VL - 520

SP - 39

EP - 46

JO - Mutation Research - Genetic Toxicology and Environmental Mutagenesis

JF - Mutation Research - Genetic Toxicology and Environmental Mutagenesis

SN - 1383-5718

IS - 1-2

ER -