Micronization of p-aminosalicylic acid particles using high-gravity technique

Yu Shao Chen, Yao Hsuan Wang, Hwai Shen Liu, Kuang Yang Hsu, Clifford Y. Tai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An antisolvent precipitation process was adopted in this study to prepare micrometer-sized p-aminosalicylic acid (PAS) particles using the high-gravity technique. The effects of operating variables on the particle size were investigated. With an increase in the dispersant concentration and disk diameter or a decrease in the drug (PAS) concentration, the particle size of PAS was reduced. In addition, a circular-tube distributor was more effective than a straight-tube distributor for micronization. On the other hand, the effect of the liquid flow rate in the range between 0.25 and 1 L/min was less significant. The high-pressure homogenization following the high-gravity precipitation would effectively reduce the agglomeration of the particles in the suspension to produce drug particles with a mean size of 1 μm. The enhancement of the dissolution rate was significant for the micronized drug particles. The results indicate that the high-gravity process is a promising approach for micronizing drug particles.

Original languageEnglish
Pages (from-to)8832-8840
Number of pages9
JournalIndustrial and Engineering Chemistry Research
Volume49
Issue number18
DOIs
Publication statusPublished - Sep 15 2010

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Aminosalicylic Acid
Gravitation
Acids
Particle size
Pharmaceutical Preparations
Dissolution
Agglomeration
Flow rate
Suspensions
Liquids

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)
  • Industrial and Manufacturing Engineering

Cite this

Micronization of p-aminosalicylic acid particles using high-gravity technique. / Chen, Yu Shao; Wang, Yao Hsuan; Liu, Hwai Shen; Hsu, Kuang Yang; Tai, Clifford Y.

In: Industrial and Engineering Chemistry Research, Vol. 49, No. 18, 15.09.2010, p. 8832-8840.

Research output: Contribution to journalArticle

Chen, Yu Shao ; Wang, Yao Hsuan ; Liu, Hwai Shen ; Hsu, Kuang Yang ; Tai, Clifford Y. / Micronization of p-aminosalicylic acid particles using high-gravity technique. In: Industrial and Engineering Chemistry Research. 2010 ; Vol. 49, No. 18. pp. 8832-8840.
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