Micronization of p-aminosalicylic acid particles using high-gravity technique

Yu Shao Chen, Yao Hsuan Wang, Hwai Shen Liu, Kuang Yang Hsu, Clifford Y. Tai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An antisolvent precipitation process was adopted in this study to prepare micrometer-sized p-aminosalicylic acid (PAS) particles using the high-gravity technique. The effects of operating variables on the particle size were investigated. With an increase in the dispersant concentration and disk diameter or a decrease in the drug (PAS) concentration, the particle size of PAS was reduced. In addition, a circular-tube distributor was more effective than a straight-tube distributor for micronization. On the other hand, the effect of the liquid flow rate in the range between 0.25 and 1 L/min was less significant. The high-pressure homogenization following the high-gravity precipitation would effectively reduce the agglomeration of the particles in the suspension to produce drug particles with a mean size of 1 μm. The enhancement of the dissolution rate was significant for the micronized drug particles. The results indicate that the high-gravity process is a promising approach for micronizing drug particles.

Original languageEnglish
Pages (from-to)8832-8840
Number of pages9
JournalIndustrial and Engineering Chemistry Research
Volume49
Issue number18
DOIs
Publication statusPublished - Sep 15 2010

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)
  • Industrial and Manufacturing Engineering

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