Microdermabrasion as a novel tool to enhance drug delivery via the skin: An animal study

Woan Ruoh Lee, Ren Yeu Tsai, Chia Lang Fang, Ching Ju Liu, Jun-Hung Hu, Jia You Fang

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

BACKGROUND: Microdermabrasion is a widely performed skin rejuvenation procedure. It can partly ablate and homogenize the stratum corneum (SC) layers. OBJECTIVE: The effect of microdermabrasion treatment on the skin permeation of hydrophilic and lipophilic drugs was examined in this study. METHODS: 5-Fluorouracil (5-FU) and clobetasol 17-propionate were used as the hydrophilic and lipophilic permeants, respectively. In vitro skin delivery using porcine skin and in vivo topical application employing nude mouse as the animal model were both used to examine the effect of microdermabrasion. The vacuum pressures used in this study (15-25 cmHg) were much lower than those used for therapeutic purposes. RESULTS: The 5-FU permeation across microdermabrasion-treated skin was 8- to 24-fold higher than that across intact skin and depended on differences in treatment pressure and duration. An intensity of 15 cmHg for 10 seconds showed the greatest enhancement of 5-FU delivery via the skin. In contrast to the results for 5-FU, microdermabrasion reduced the skin permeation and deposition of topically applied clobetasol. The partitioning effect of clobetasol from the vehicle to the SC may have predominated this result. Microdermabrasion also enhanced the skin delivery of the hydrophilic 5-aminolevulinic acid (ALA). Confocal laser scanning microscopy (CLSM) of microdermabrasion-treated skin revealed intense red fluorescence of ALA-transformed protoporphyrin (PpIX) within the epidermis and upper dermis. CONCLUSIONS: Microdermabrasion can improve the skin permeation of hydrophilic molecules.

Original languageEnglish
Pages (from-to)1013-1022
Number of pages10
JournalDermatologic Surgery
Volume32
Issue number8
DOIs
Publication statusPublished - Aug 2006

Fingerprint

Skin
Pharmaceutical Preparations
Clobetasol
Fluorouracil
Aminolevulinic Acid
Cornea
Rejuvenation
Pressure
Dermis
Vacuum
Nude Mice
Epidermis
Confocal Microscopy
Swine
Therapeutics
Animal Models
Fluorescence

ASJC Scopus subject areas

  • Dermatology
  • Surgery

Cite this

Microdermabrasion as a novel tool to enhance drug delivery via the skin : An animal study. / Lee, Woan Ruoh; Tsai, Ren Yeu; Fang, Chia Lang; Liu, Ching Ju; Hu, Jun-Hung; Fang, Jia You.

In: Dermatologic Surgery, Vol. 32, No. 8, 08.2006, p. 1013-1022.

Research output: Contribution to journalArticle

Lee, Woan Ruoh ; Tsai, Ren Yeu ; Fang, Chia Lang ; Liu, Ching Ju ; Hu, Jun-Hung ; Fang, Jia You. / Microdermabrasion as a novel tool to enhance drug delivery via the skin : An animal study. In: Dermatologic Surgery. 2006 ; Vol. 32, No. 8. pp. 1013-1022.
@article{99bc730fee4342a1986cb33e4407506b,
title = "Microdermabrasion as a novel tool to enhance drug delivery via the skin: An animal study",
abstract = "BACKGROUND: Microdermabrasion is a widely performed skin rejuvenation procedure. It can partly ablate and homogenize the stratum corneum (SC) layers. OBJECTIVE: The effect of microdermabrasion treatment on the skin permeation of hydrophilic and lipophilic drugs was examined in this study. METHODS: 5-Fluorouracil (5-FU) and clobetasol 17-propionate were used as the hydrophilic and lipophilic permeants, respectively. In vitro skin delivery using porcine skin and in vivo topical application employing nude mouse as the animal model were both used to examine the effect of microdermabrasion. The vacuum pressures used in this study (15-25 cmHg) were much lower than those used for therapeutic purposes. RESULTS: The 5-FU permeation across microdermabrasion-treated skin was 8- to 24-fold higher than that across intact skin and depended on differences in treatment pressure and duration. An intensity of 15 cmHg for 10 seconds showed the greatest enhancement of 5-FU delivery via the skin. In contrast to the results for 5-FU, microdermabrasion reduced the skin permeation and deposition of topically applied clobetasol. The partitioning effect of clobetasol from the vehicle to the SC may have predominated this result. Microdermabrasion also enhanced the skin delivery of the hydrophilic 5-aminolevulinic acid (ALA). Confocal laser scanning microscopy (CLSM) of microdermabrasion-treated skin revealed intense red fluorescence of ALA-transformed protoporphyrin (PpIX) within the epidermis and upper dermis. CONCLUSIONS: Microdermabrasion can improve the skin permeation of hydrophilic molecules.",
author = "Lee, {Woan Ruoh} and Tsai, {Ren Yeu} and Fang, {Chia Lang} and Liu, {Ching Ju} and Jun-Hung Hu and Fang, {Jia You}",
year = "2006",
month = "8",
doi = "10.1111/j.1524-4725.2006.32224.x",
language = "English",
volume = "32",
pages = "1013--1022",
journal = "Dermatologic Surgery",
issn = "1076-0512",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Microdermabrasion as a novel tool to enhance drug delivery via the skin

T2 - An animal study

AU - Lee, Woan Ruoh

AU - Tsai, Ren Yeu

AU - Fang, Chia Lang

AU - Liu, Ching Ju

AU - Hu, Jun-Hung

AU - Fang, Jia You

PY - 2006/8

Y1 - 2006/8

N2 - BACKGROUND: Microdermabrasion is a widely performed skin rejuvenation procedure. It can partly ablate and homogenize the stratum corneum (SC) layers. OBJECTIVE: The effect of microdermabrasion treatment on the skin permeation of hydrophilic and lipophilic drugs was examined in this study. METHODS: 5-Fluorouracil (5-FU) and clobetasol 17-propionate were used as the hydrophilic and lipophilic permeants, respectively. In vitro skin delivery using porcine skin and in vivo topical application employing nude mouse as the animal model were both used to examine the effect of microdermabrasion. The vacuum pressures used in this study (15-25 cmHg) were much lower than those used for therapeutic purposes. RESULTS: The 5-FU permeation across microdermabrasion-treated skin was 8- to 24-fold higher than that across intact skin and depended on differences in treatment pressure and duration. An intensity of 15 cmHg for 10 seconds showed the greatest enhancement of 5-FU delivery via the skin. In contrast to the results for 5-FU, microdermabrasion reduced the skin permeation and deposition of topically applied clobetasol. The partitioning effect of clobetasol from the vehicle to the SC may have predominated this result. Microdermabrasion also enhanced the skin delivery of the hydrophilic 5-aminolevulinic acid (ALA). Confocal laser scanning microscopy (CLSM) of microdermabrasion-treated skin revealed intense red fluorescence of ALA-transformed protoporphyrin (PpIX) within the epidermis and upper dermis. CONCLUSIONS: Microdermabrasion can improve the skin permeation of hydrophilic molecules.

AB - BACKGROUND: Microdermabrasion is a widely performed skin rejuvenation procedure. It can partly ablate and homogenize the stratum corneum (SC) layers. OBJECTIVE: The effect of microdermabrasion treatment on the skin permeation of hydrophilic and lipophilic drugs was examined in this study. METHODS: 5-Fluorouracil (5-FU) and clobetasol 17-propionate were used as the hydrophilic and lipophilic permeants, respectively. In vitro skin delivery using porcine skin and in vivo topical application employing nude mouse as the animal model were both used to examine the effect of microdermabrasion. The vacuum pressures used in this study (15-25 cmHg) were much lower than those used for therapeutic purposes. RESULTS: The 5-FU permeation across microdermabrasion-treated skin was 8- to 24-fold higher than that across intact skin and depended on differences in treatment pressure and duration. An intensity of 15 cmHg for 10 seconds showed the greatest enhancement of 5-FU delivery via the skin. In contrast to the results for 5-FU, microdermabrasion reduced the skin permeation and deposition of topically applied clobetasol. The partitioning effect of clobetasol from the vehicle to the SC may have predominated this result. Microdermabrasion also enhanced the skin delivery of the hydrophilic 5-aminolevulinic acid (ALA). Confocal laser scanning microscopy (CLSM) of microdermabrasion-treated skin revealed intense red fluorescence of ALA-transformed protoporphyrin (PpIX) within the epidermis and upper dermis. CONCLUSIONS: Microdermabrasion can improve the skin permeation of hydrophilic molecules.

UR - http://www.scopus.com/inward/record.url?scp=33746916407&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746916407&partnerID=8YFLogxK

U2 - 10.1111/j.1524-4725.2006.32224.x

DO - 10.1111/j.1524-4725.2006.32224.x

M3 - Article

C2 - 16918563

AN - SCOPUS:33746916407

VL - 32

SP - 1013

EP - 1022

JO - Dermatologic Surgery

JF - Dermatologic Surgery

SN - 1076-0512

IS - 8

ER -