Microbial contamination of the Tzu-Chi cord blood bank from 2005 to 2006

Shu Huey Chen, Ya Jun Zheng, Shang Hsien Yang, Kuo Liang Yang, Ming Hwang Shyr, Yu Huai Ho

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: In total, 4502 units of cord blood (CB) were collected during a 2-year period from 2005 to 2006 by the Buddhist Tzu-Chi Stem Cells Center. The aim of this study was to analyze the incidence of microbial contamination and type of organism present in the cord blood. The clinical impact of microbial contamination on hematopoietic progenitor cell (HPC) grafts used for HPC transplantation is also discussed. Methods: First and second specimens were obtained for microbial assessment. These were collected in laboratory after cord blood collection and after cord blood unit manipulation, respectively. The samples were cultured and the results reviewed. Results: The overall incidence of microbiological contamination was 1.8% (82/4502). Three CB units were contaminated with two different organisms. Infectious organisms comprised 9. 4%(8/85) of total isolated microbes. These infectious microorganisms were β-Streptococci group B, Candida tropicalis and Staphylococcus aureus which were isolated in 6, 1 and 1 of CB units respectively. Escherichia coli, Bacteroides fragilis, Lactobacillus spp., Enterococcus, β-Streptococcus Group B, Bacteroides valgatus, Corynebacterium spp., Klebsiella pneumonia and Peptococcus spp. were the most frequently encountered microorganisms. A higher contamination rate of the CB units was noted after vaginal delivery (2.16%) compared to caesarian section (0.85%) (p

Original languageEnglish
JournalActa Paediatrica Taiwanica
Volume49
Issue number1
Publication statusPublished - Jan 2008
Externally publishedYes

Fingerprint

Blood Banks
Fetal Blood
Streptococcus agalactiae
Hematopoietic Stem Cells
Peptococcus
Candida tropicalis
Bacteroides fragilis
Corynebacterium
Bacteroides
Incidence
Cell Transplantation
Enterococcus
Klebsiella pneumoniae
Lactobacillus
Cesarean Section
Staphylococcus aureus
Stem Cells
Escherichia coli
Transplants

Keywords

  • Cord blood
  • Hematopoietic progenitor cells
  • Microbial contamination

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Chen, S. H., Zheng, Y. J., Yang, S. H., Yang, K. L., Shyr, M. H., & Ho, Y. H. (2008). Microbial contamination of the Tzu-Chi cord blood bank from 2005 to 2006. Acta Paediatrica Taiwanica, 49(1).

Microbial contamination of the Tzu-Chi cord blood bank from 2005 to 2006. / Chen, Shu Huey; Zheng, Ya Jun; Yang, Shang Hsien; Yang, Kuo Liang; Shyr, Ming Hwang; Ho, Yu Huai.

In: Acta Paediatrica Taiwanica, Vol. 49, No. 1, 01.2008.

Research output: Contribution to journalArticle

Chen, SH, Zheng, YJ, Yang, SH, Yang, KL, Shyr, MH & Ho, YH 2008, 'Microbial contamination of the Tzu-Chi cord blood bank from 2005 to 2006', Acta Paediatrica Taiwanica, vol. 49, no. 1.
Chen, Shu Huey ; Zheng, Ya Jun ; Yang, Shang Hsien ; Yang, Kuo Liang ; Shyr, Ming Hwang ; Ho, Yu Huai. / Microbial contamination of the Tzu-Chi cord blood bank from 2005 to 2006. In: Acta Paediatrica Taiwanica. 2008 ; Vol. 49, No. 1.
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