Micro diffuser-type movement inversion sorter for high-efficient sperm sorting

Yu Nan Lin, Peng Chun Chen, Ren Guei Wu, Li Chern Pan, Fan Gang Tseng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

In this study, we propose a microfluidic device with a diffuser type chamber to differentiate the sperm velocity by gradually lowering down the flow speed in diffuser by gradually increasing the width of the channel. When the sperms' moving speed match the flow speed, the sperms tend to have the ability to flow against the stream, thus separating the sperms at different specific positions along the diffuser according to their motility becomes gentle and fast. Most of the motile sperm will stay in the expanding area and the non-motile sperms will drift to outlet. Different from the previous study we proposed in IEEE NEMS, 2012, here we have three improvements: (1) Sperms can be separated in more detailed quality level. (2) Sperm will be more activated by passing through a dumb bell area than by the traditional methods. (3) The space in the device can accumulate large amount of sperms (∼millions).

Original languageEnglish
Title of host publication8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
Pages1058-1061
Number of pages4
DOIs
Publication statusPublished - 2013
Externally publishedYes
Event8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013 - Suzhou, China
Duration: Apr 7 2013Apr 10 2013

Other

Other8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
CountryChina
CitySuzhou
Period4/7/134/10/13

Keywords

  • microfluidic-based chip
  • separation
  • sperm

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Biotechnology

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  • Cite this

    Lin, Y. N., Chen, P. C., Wu, R. G., Pan, L. C., & Tseng, F. G. (2013). Micro diffuser-type movement inversion sorter for high-efficient sperm sorting. In 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013 (pp. 1058-1061). [6559904] https://doi.org/10.1109/NEMS.2013.6559904