Methionine synthase 2756AA polymorphism is associated with the risk of cognitive impairment in patients with late-life depression

Ya Hsu Yang, Chih Chiang Chiu, Hao Wei Teng, Chih Pang Chu, Ching Jui Chang, Wei Che Chiu, Chin Hsin Chen, Mong Liang Lu, Shen Ing Liu, Shih Yi Huang, Hsing Cheng Liu, I. Wen Sun

Research output: Contribution to journalArticle

Abstract

Backgrounds: Apolipoprotein E epsilon-4 (APOE ε4) allele, methylenetetrahydrofolate reductase (MTHFR C677T), and methionine synthase (MTR A2756G) were tested their associations with cognitive impairment in people with late-life depression (LLD). Methods: People with LLD were assessed by mini-mental state examination and were examined the distribution of APOE ε4 allele, MTHFR, and MTR polymorphisms. Results: Odds ratio of MTR 2756 AA to MTR 2756 AG and GG genotypes for the risk of cognitive impairment was 5.80 (95% confidence interval=1.18-28.50; P=0.03). Conclusion: People with LLD carrying MTR2756 AA genotype have higher risk of cognitive impairment than those carrying G allele.

Original languageEnglish
JournalAsia-Pacific Psychiatry
Volume9
Issue number1
DOIs
Publication statusPublished - Mar 1 2017

Fingerprint

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Apolipoprotein E4
Alleles
Depression
Genotype
Methylenetetrahydrofolate Reductase (NADPH2)
Odds Ratio
Confidence Intervals
Cognitive Dysfunction

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Methionine synthase 2756AA polymorphism is associated with the risk of cognitive impairment in patients with late-life depression. / Yang, Ya Hsu; Chiu, Chih Chiang; Teng, Hao Wei; Chu, Chih Pang; Chang, Ching Jui; Chiu, Wei Che; Chen, Chin Hsin; Lu, Mong Liang; Liu, Shen Ing; Huang, Shih Yi; Liu, Hsing Cheng; Sun, I. Wen.

In: Asia-Pacific Psychiatry, Vol. 9, No. 1, 01.03.2017.

Research output: Contribution to journalArticle

Yang, Ya Hsu ; Chiu, Chih Chiang ; Teng, Hao Wei ; Chu, Chih Pang ; Chang, Ching Jui ; Chiu, Wei Che ; Chen, Chin Hsin ; Lu, Mong Liang ; Liu, Shen Ing ; Huang, Shih Yi ; Liu, Hsing Cheng ; Sun, I. Wen. / Methionine synthase 2756AA polymorphism is associated with the risk of cognitive impairment in patients with late-life depression. In: Asia-Pacific Psychiatry. 2017 ; Vol. 9, No. 1.
@article{6d40ac64d5f843daba820514621955b1,
title = "Methionine synthase 2756AA polymorphism is associated with the risk of cognitive impairment in patients with late-life depression",
abstract = "Backgrounds: Apolipoprotein E epsilon-4 (APOE ε4) allele, methylenetetrahydrofolate reductase (MTHFR C677T), and methionine synthase (MTR A2756G) were tested their associations with cognitive impairment in people with late-life depression (LLD). Methods: People with LLD were assessed by mini-mental state examination and were examined the distribution of APOE ε4 allele, MTHFR, and MTR polymorphisms. Results: Odds ratio of MTR 2756 AA to MTR 2756 AG and GG genotypes for the risk of cognitive impairment was 5.80 (95{\%} confidence interval=1.18-28.50; P=0.03). Conclusion: People with LLD carrying MTR2756 AA genotype have higher risk of cognitive impairment than those carrying G allele.",
author = "Yang, {Ya Hsu} and Chiu, {Chih Chiang} and Teng, {Hao Wei} and Chu, {Chih Pang} and Chang, {Ching Jui} and Chiu, {Wei Che} and Chen, {Chin Hsin} and Lu, {Mong Liang} and Liu, {Shen Ing} and Huang, {Shih Yi} and Liu, {Hsing Cheng} and Sun, {I. Wen}",
year = "2017",
month = "3",
day = "1",
doi = "10.1111/appy.12242",
language = "English",
volume = "9",
journal = "Asia-Pacific Psychiatry",
issn = "1758-5864",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Methionine synthase 2756AA polymorphism is associated with the risk of cognitive impairment in patients with late-life depression

AU - Yang, Ya Hsu

AU - Chiu, Chih Chiang

AU - Teng, Hao Wei

AU - Chu, Chih Pang

AU - Chang, Ching Jui

AU - Chiu, Wei Che

AU - Chen, Chin Hsin

AU - Lu, Mong Liang

AU - Liu, Shen Ing

AU - Huang, Shih Yi

AU - Liu, Hsing Cheng

AU - Sun, I. Wen

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Backgrounds: Apolipoprotein E epsilon-4 (APOE ε4) allele, methylenetetrahydrofolate reductase (MTHFR C677T), and methionine synthase (MTR A2756G) were tested their associations with cognitive impairment in people with late-life depression (LLD). Methods: People with LLD were assessed by mini-mental state examination and were examined the distribution of APOE ε4 allele, MTHFR, and MTR polymorphisms. Results: Odds ratio of MTR 2756 AA to MTR 2756 AG and GG genotypes for the risk of cognitive impairment was 5.80 (95% confidence interval=1.18-28.50; P=0.03). Conclusion: People with LLD carrying MTR2756 AA genotype have higher risk of cognitive impairment than those carrying G allele.

AB - Backgrounds: Apolipoprotein E epsilon-4 (APOE ε4) allele, methylenetetrahydrofolate reductase (MTHFR C677T), and methionine synthase (MTR A2756G) were tested their associations with cognitive impairment in people with late-life depression (LLD). Methods: People with LLD were assessed by mini-mental state examination and were examined the distribution of APOE ε4 allele, MTHFR, and MTR polymorphisms. Results: Odds ratio of MTR 2756 AA to MTR 2756 AG and GG genotypes for the risk of cognitive impairment was 5.80 (95% confidence interval=1.18-28.50; P=0.03). Conclusion: People with LLD carrying MTR2756 AA genotype have higher risk of cognitive impairment than those carrying G allele.

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85011976009&origin=resultslist&sort=plf-f&src=s&st1=Methionine+synthase+2756AA+polymorphism+is+associated+with+the+risk+of+cognitive+impairment+in+patients+with+late-life+depression&st2=&sid=a808d1175da84d855978dbe7e60ab8a3&sot=b&sdt=b&sl=144&s=TITLE-ABS-KEY%28Methionine+synthase+2756AA+polymorphism+is+associated+with+the+risk+of+cognitive+impairment+in+patients+with+late-life+depression%29&relpos=0&citeCnt=0&searchTerm=

UR - https://www.scopus.com/results/citedbyresults.uri?sort=r-f&src=s&mltEid=2-s2.0-85011976009&mltType=ref&mltAll=t&imp=t&sid=75a3e6a3ba799bdf219edefb689c30b8&sot=mlt&sdt=mlt&sl=342&s=REFEID%28%28%222-s2.0-0034054268%22%29+OR+%28%222-s2.0-10044287359%22%29+OR+%28%222-s2.0-0041699719%22%29+OR+%28%222-s2.0-3042835576%22%29+OR+%28%222-s2.0-0345737212%22%29+OR+%28%222-s2.0-84863078139%22%29+OR+%28%222-s2.0-34548329578%22%29+OR+%28%222-s2.0-0016823810%22%29+OR+%28%222-s2.0-32244438738%22%29+OR+%28%222-s2.0-0003143596%22%29+OR+%28%222-s2.0-7244229777%22%29+OR+%28%222-s2.0-10044243556%22%29%29+AND+NOT+EID+%282-s2.0-85011976009%29&origin=recordpage&txGid=206ffd7510cb8d0f872029ae3f8b748e

U2 - 10.1111/appy.12242

DO - 10.1111/appy.12242

M3 - Article

C2 - 27111719

AN - SCOPUS:85011976009

VL - 9

JO - Asia-Pacific Psychiatry

JF - Asia-Pacific Psychiatry

SN - 1758-5864

IS - 1

ER -