Methamphetamine downregulates peroxiredoxins in rat pheochromocytoma cells

Han Min Chen, Yi Chao Lee, Chuen Lin Huang, Hui Kang Liu, Wei Chen Liao, Wen Lin Lai, Yen Ru Lin, Nai Kuei Huang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Methamphetamine (METH) is an abusive psychostimulant that induces neuronal cell death/degeneration in experimental animals and humans. METH-induced apoptosis in rat pheochromocytoma cells was utilized to study the neurotoxic mechanism. During METH intoxication, we found that peroxiredoxins and thioredoxins/thioredoxin reductases (peroxiredoxin reducing systems) which are known to prevent oxidative stress and apoptosis were differentially downregulated and upregulated, respectively. We also found not only the free radicals but also the oxidative forms of peroxiredoxin and thioredoxin were increased, indicating the dysfunction of these enzymes. Thus, METH-induced differential regulation and oxidation of peroxiredoxins and thioredoxin may be an important mechanism for apoptosis.

Original languageEnglish
Pages (from-to)96-101
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume354
Issue number1
DOIs
Publication statusPublished - Mar 2 2007
Externally publishedYes

Keywords

  • Methamphetamine
  • Peroxiredoxin
  • Thioredoxin
  • Thioredoxin reductase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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