Metabolic syndrome defined by IDF and AHA/NHLBI correlates better to carotid intima-media thickness than that defined by NCEP ATP III and WHO

Wen Ya Ma, Hung Yuan Li, Chi Sheng Hung, Mao Shin Lin, Fu Chun Chiu, Cheng Hsin Lin, Shyang Rong Shih, Lee Ming Chuang, Jung Nan Wei

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Aims: We conducted this study to compare the relationships between subclinical atherosclerosis and metabolic syndrome (MS) defined by four definitions in Chinese subjects. Methods: In 2006-2007, we enrolled 140 Chinese subjects without reported diabetes in this study. Anthropometric, biochemical profile, and carotid intima-media thickness (IMT) were measured. MS was defined by International Diabetes Federation (IDF), American Heart Association and the National Heart, Lung, and Blood Institute (AHA/NHLBI), National Cholesterol Education Program Adult Treatment Panal III (NCEP-ATP III), and World Health Organization (WHO) criteria. Results: Subjects with MS defined by IDF and AHA/NHLBI criteria had significantly higher carotid IMT, controlling for age, gender, smoking, and serum LDL-C (MS by IDF, partial r = 0.225, p = 0.008; AHA/NHLBI, partial r = 0.176, p = 0.04). The association between carotid IMT and MS defined by NCEP-ATP III or WHO criteria was not significant. Subjects with more components of MS defined by IDF, AHA/NHLBI, or NCEP-ATP III criteria correlated to higher carotid IMT in adjusted models (p-values for trend, MS by IDF, 0.011; AHA/NHLBI, 0.011; NCEP-ATPIII, 0.01; WHO, 0.113). Conclusion: MS definitions by IDF and AHA/NHLBI criteria are the best among four definitions in detecting subclinical atherosclerosis in non-diabetic Chinese subjects; whereas MS defined by WHO criteria is the worst.

Original languageEnglish
Pages (from-to)335-341
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume85
Issue number3
DOIs
Publication statusPublished - Sep 2009
Externally publishedYes

Fingerprint

American Heart Association
National Heart, Lung, and Blood Institute (U.S.)
Carotid Intima-Media Thickness
Adenosine Triphosphate
Cholesterol
Education
Atherosclerosis
Therapeutics
Smoking

Keywords

  • Atherosclerosis
  • Carotid intima-media thickness
  • Metabolic syndrome

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Endocrinology

Cite this

Metabolic syndrome defined by IDF and AHA/NHLBI correlates better to carotid intima-media thickness than that defined by NCEP ATP III and WHO. / Ma, Wen Ya; Li, Hung Yuan; Hung, Chi Sheng; Lin, Mao Shin; Chiu, Fu Chun; Lin, Cheng Hsin; Shih, Shyang Rong; Chuang, Lee Ming; Wei, Jung Nan.

In: Diabetes Research and Clinical Practice, Vol. 85, No. 3, 09.2009, p. 335-341.

Research output: Contribution to journalArticle

Ma, Wen Ya ; Li, Hung Yuan ; Hung, Chi Sheng ; Lin, Mao Shin ; Chiu, Fu Chun ; Lin, Cheng Hsin ; Shih, Shyang Rong ; Chuang, Lee Ming ; Wei, Jung Nan. / Metabolic syndrome defined by IDF and AHA/NHLBI correlates better to carotid intima-media thickness than that defined by NCEP ATP III and WHO. In: Diabetes Research and Clinical Practice. 2009 ; Vol. 85, No. 3. pp. 335-341.
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abstract = "Aims: We conducted this study to compare the relationships between subclinical atherosclerosis and metabolic syndrome (MS) defined by four definitions in Chinese subjects. Methods: In 2006-2007, we enrolled 140 Chinese subjects without reported diabetes in this study. Anthropometric, biochemical profile, and carotid intima-media thickness (IMT) were measured. MS was defined by International Diabetes Federation (IDF), American Heart Association and the National Heart, Lung, and Blood Institute (AHA/NHLBI), National Cholesterol Education Program Adult Treatment Panal III (NCEP-ATP III), and World Health Organization (WHO) criteria. Results: Subjects with MS defined by IDF and AHA/NHLBI criteria had significantly higher carotid IMT, controlling for age, gender, smoking, and serum LDL-C (MS by IDF, partial r = 0.225, p = 0.008; AHA/NHLBI, partial r = 0.176, p = 0.04). The association between carotid IMT and MS defined by NCEP-ATP III or WHO criteria was not significant. Subjects with more components of MS defined by IDF, AHA/NHLBI, or NCEP-ATP III criteria correlated to higher carotid IMT in adjusted models (p-values for trend, MS by IDF, 0.011; AHA/NHLBI, 0.011; NCEP-ATPIII, 0.01; WHO, 0.113). Conclusion: MS definitions by IDF and AHA/NHLBI criteria are the best among four definitions in detecting subclinical atherosclerosis in non-diabetic Chinese subjects; whereas MS defined by WHO criteria is the worst.",
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T1 - Metabolic syndrome defined by IDF and AHA/NHLBI correlates better to carotid intima-media thickness than that defined by NCEP ATP III and WHO

AU - Ma, Wen Ya

AU - Li, Hung Yuan

AU - Hung, Chi Sheng

AU - Lin, Mao Shin

AU - Chiu, Fu Chun

AU - Lin, Cheng Hsin

AU - Shih, Shyang Rong

AU - Chuang, Lee Ming

AU - Wei, Jung Nan

PY - 2009/9

Y1 - 2009/9

N2 - Aims: We conducted this study to compare the relationships between subclinical atherosclerosis and metabolic syndrome (MS) defined by four definitions in Chinese subjects. Methods: In 2006-2007, we enrolled 140 Chinese subjects without reported diabetes in this study. Anthropometric, biochemical profile, and carotid intima-media thickness (IMT) were measured. MS was defined by International Diabetes Federation (IDF), American Heart Association and the National Heart, Lung, and Blood Institute (AHA/NHLBI), National Cholesterol Education Program Adult Treatment Panal III (NCEP-ATP III), and World Health Organization (WHO) criteria. Results: Subjects with MS defined by IDF and AHA/NHLBI criteria had significantly higher carotid IMT, controlling for age, gender, smoking, and serum LDL-C (MS by IDF, partial r = 0.225, p = 0.008; AHA/NHLBI, partial r = 0.176, p = 0.04). The association between carotid IMT and MS defined by NCEP-ATP III or WHO criteria was not significant. Subjects with more components of MS defined by IDF, AHA/NHLBI, or NCEP-ATP III criteria correlated to higher carotid IMT in adjusted models (p-values for trend, MS by IDF, 0.011; AHA/NHLBI, 0.011; NCEP-ATPIII, 0.01; WHO, 0.113). Conclusion: MS definitions by IDF and AHA/NHLBI criteria are the best among four definitions in detecting subclinical atherosclerosis in non-diabetic Chinese subjects; whereas MS defined by WHO criteria is the worst.

AB - Aims: We conducted this study to compare the relationships between subclinical atherosclerosis and metabolic syndrome (MS) defined by four definitions in Chinese subjects. Methods: In 2006-2007, we enrolled 140 Chinese subjects without reported diabetes in this study. Anthropometric, biochemical profile, and carotid intima-media thickness (IMT) were measured. MS was defined by International Diabetes Federation (IDF), American Heart Association and the National Heart, Lung, and Blood Institute (AHA/NHLBI), National Cholesterol Education Program Adult Treatment Panal III (NCEP-ATP III), and World Health Organization (WHO) criteria. Results: Subjects with MS defined by IDF and AHA/NHLBI criteria had significantly higher carotid IMT, controlling for age, gender, smoking, and serum LDL-C (MS by IDF, partial r = 0.225, p = 0.008; AHA/NHLBI, partial r = 0.176, p = 0.04). The association between carotid IMT and MS defined by NCEP-ATP III or WHO criteria was not significant. Subjects with more components of MS defined by IDF, AHA/NHLBI, or NCEP-ATP III criteria correlated to higher carotid IMT in adjusted models (p-values for trend, MS by IDF, 0.011; AHA/NHLBI, 0.011; NCEP-ATPIII, 0.01; WHO, 0.113). Conclusion: MS definitions by IDF and AHA/NHLBI criteria are the best among four definitions in detecting subclinical atherosclerosis in non-diabetic Chinese subjects; whereas MS defined by WHO criteria is the worst.

KW - Atherosclerosis

KW - Carotid intima-media thickness

KW - Metabolic syndrome

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