Metabolic syndrome components worsen lower urinary tract symptoms in women with type 2 diabetes

Huai Ching Tai, Shiu Dong Chung, Chen Hsun Ho, Tong Yuan Tai, Wei Shiung Yang, Chin Hsiao Tseng, Huey Peir Wu, Hong Jeng Yu

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Context: Diabetic women are more susceptible to develop lower urinary tract symptoms (LUTS), especially overactive bladder (OAB). However, data regarding the effect of components of metabolic syndrome (MS) on this association are conflicting. Objective: The objective of the study was to examine the potential role of MS in the development of LUTS in diabetic women. Design: The study was a prevalence study conducted between 2005 and 2007. Setting: The study was conducted in a university hospital. Participants: A total of 518 women with type 2 diabetes aged 50-75 yr were included. They were subgrouped as MS (47.5%) and non-MS (52.5%) groups according to whether they fulfilled the criteria of MS. Main Outcome Measure: We used American Urological Association Symptom Index (AUA-SI) to evaluate LUTS and Indevus Urgency Severity Scale to evaluate OAB, respectively. Results: Women in the MS group had significantly higher storage and total AUA-SI scores as well as a higher prevalence of LUTS and OAB. Most intriguingly, the number of MS components was strongly associated with the LUTS severity because the AUA-SI scores increased in parallel to the number of components were present. Similar results were found between MS and OAB. Multivariate analysis revealed that peripheral neuropathy, but not MS, significantly predicted LUTS in diabeticwomenafter age adjustment. However,MSremained significantly predictive for LUTS and OAB after additional adjustment for neuropathy. Conclusions: Our results suggest that MS may especially influence LUTS and OAB in diabetic women, probably by compounding the effect of peripheral neuropathy.

Original languageEnglish
Pages (from-to)1143-1150
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume95
Issue number3
DOIs
Publication statusPublished - Jan 1 2010
Externally publishedYes

Fingerprint

Lower Urinary Tract Symptoms
Medical problems
Type 2 Diabetes Mellitus
Overactive Urinary Bladder
Peripheral Nervous System Diseases
Multivariate Analysis
Cross-Sectional Studies
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Metabolic syndrome components worsen lower urinary tract symptoms in women with type 2 diabetes. / Tai, Huai Ching; Chung, Shiu Dong; Ho, Chen Hsun; Tai, Tong Yuan; Yang, Wei Shiung; Tseng, Chin Hsiao; Wu, Huey Peir; Yu, Hong Jeng.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 95, No. 3, 01.01.2010, p. 1143-1150.

Research output: Contribution to journalArticle

Tai, Huai Ching ; Chung, Shiu Dong ; Ho, Chen Hsun ; Tai, Tong Yuan ; Yang, Wei Shiung ; Tseng, Chin Hsiao ; Wu, Huey Peir ; Yu, Hong Jeng. / Metabolic syndrome components worsen lower urinary tract symptoms in women with type 2 diabetes. In: Journal of Clinical Endocrinology and Metabolism. 2010 ; Vol. 95, No. 3. pp. 1143-1150.
@article{99ef480a95c247c293102df8742f3869,
title = "Metabolic syndrome components worsen lower urinary tract symptoms in women with type 2 diabetes",
abstract = "Context: Diabetic women are more susceptible to develop lower urinary tract symptoms (LUTS), especially overactive bladder (OAB). However, data regarding the effect of components of metabolic syndrome (MS) on this association are conflicting. Objective: The objective of the study was to examine the potential role of MS in the development of LUTS in diabetic women. Design: The study was a prevalence study conducted between 2005 and 2007. Setting: The study was conducted in a university hospital. Participants: A total of 518 women with type 2 diabetes aged 50-75 yr were included. They were subgrouped as MS (47.5{\%}) and non-MS (52.5{\%}) groups according to whether they fulfilled the criteria of MS. Main Outcome Measure: We used American Urological Association Symptom Index (AUA-SI) to evaluate LUTS and Indevus Urgency Severity Scale to evaluate OAB, respectively. Results: Women in the MS group had significantly higher storage and total AUA-SI scores as well as a higher prevalence of LUTS and OAB. Most intriguingly, the number of MS components was strongly associated with the LUTS severity because the AUA-SI scores increased in parallel to the number of components were present. Similar results were found between MS and OAB. Multivariate analysis revealed that peripheral neuropathy, but not MS, significantly predicted LUTS in diabeticwomenafter age adjustment. However,MSremained significantly predictive for LUTS and OAB after additional adjustment for neuropathy. Conclusions: Our results suggest that MS may especially influence LUTS and OAB in diabetic women, probably by compounding the effect of peripheral neuropathy.",
author = "Tai, {Huai Ching} and Chung, {Shiu Dong} and Ho, {Chen Hsun} and Tai, {Tong Yuan} and Yang, {Wei Shiung} and Tseng, {Chin Hsiao} and Wu, {Huey Peir} and Yu, {Hong Jeng}",
year = "2010",
month = "1",
day = "1",
doi = "10.1210/jc.2009-1492",
language = "English",
volume = "95",
pages = "1143--1150",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "3",

}

TY - JOUR

T1 - Metabolic syndrome components worsen lower urinary tract symptoms in women with type 2 diabetes

AU - Tai, Huai Ching

AU - Chung, Shiu Dong

AU - Ho, Chen Hsun

AU - Tai, Tong Yuan

AU - Yang, Wei Shiung

AU - Tseng, Chin Hsiao

AU - Wu, Huey Peir

AU - Yu, Hong Jeng

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Context: Diabetic women are more susceptible to develop lower urinary tract symptoms (LUTS), especially overactive bladder (OAB). However, data regarding the effect of components of metabolic syndrome (MS) on this association are conflicting. Objective: The objective of the study was to examine the potential role of MS in the development of LUTS in diabetic women. Design: The study was a prevalence study conducted between 2005 and 2007. Setting: The study was conducted in a university hospital. Participants: A total of 518 women with type 2 diabetes aged 50-75 yr were included. They were subgrouped as MS (47.5%) and non-MS (52.5%) groups according to whether they fulfilled the criteria of MS. Main Outcome Measure: We used American Urological Association Symptom Index (AUA-SI) to evaluate LUTS and Indevus Urgency Severity Scale to evaluate OAB, respectively. Results: Women in the MS group had significantly higher storage and total AUA-SI scores as well as a higher prevalence of LUTS and OAB. Most intriguingly, the number of MS components was strongly associated with the LUTS severity because the AUA-SI scores increased in parallel to the number of components were present. Similar results were found between MS and OAB. Multivariate analysis revealed that peripheral neuropathy, but not MS, significantly predicted LUTS in diabeticwomenafter age adjustment. However,MSremained significantly predictive for LUTS and OAB after additional adjustment for neuropathy. Conclusions: Our results suggest that MS may especially influence LUTS and OAB in diabetic women, probably by compounding the effect of peripheral neuropathy.

AB - Context: Diabetic women are more susceptible to develop lower urinary tract symptoms (LUTS), especially overactive bladder (OAB). However, data regarding the effect of components of metabolic syndrome (MS) on this association are conflicting. Objective: The objective of the study was to examine the potential role of MS in the development of LUTS in diabetic women. Design: The study was a prevalence study conducted between 2005 and 2007. Setting: The study was conducted in a university hospital. Participants: A total of 518 women with type 2 diabetes aged 50-75 yr were included. They were subgrouped as MS (47.5%) and non-MS (52.5%) groups according to whether they fulfilled the criteria of MS. Main Outcome Measure: We used American Urological Association Symptom Index (AUA-SI) to evaluate LUTS and Indevus Urgency Severity Scale to evaluate OAB, respectively. Results: Women in the MS group had significantly higher storage and total AUA-SI scores as well as a higher prevalence of LUTS and OAB. Most intriguingly, the number of MS components was strongly associated with the LUTS severity because the AUA-SI scores increased in parallel to the number of components were present. Similar results were found between MS and OAB. Multivariate analysis revealed that peripheral neuropathy, but not MS, significantly predicted LUTS in diabeticwomenafter age adjustment. However,MSremained significantly predictive for LUTS and OAB after additional adjustment for neuropathy. Conclusions: Our results suggest that MS may especially influence LUTS and OAB in diabetic women, probably by compounding the effect of peripheral neuropathy.

UR - http://www.scopus.com/inward/record.url?scp=77749270919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77749270919&partnerID=8YFLogxK

U2 - 10.1210/jc.2009-1492

DO - 10.1210/jc.2009-1492

M3 - Article

AN - SCOPUS:77749270919

VL - 95

SP - 1143

EP - 1150

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 3

ER -