Metabolic acidosis and strong ion gap in critically ill patients with acute kidney injury

Cai Mei Zheng, Wen Chih Liu, Jing Quan Zheng, Min Tser Liao, Wen Ya Ma, Kuo Chin Hung, Chien Lin Lu, Chia Chao Wu, Kuo Cheng Lu

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Abstract

Purpose. To determine the influence of physicochemical parameters on survival in metabolic acidosis (MA) and acute kidney injury (AKI) patients. Materials and Methods. Seventy-eight MA patients were collected and assigned to AKI or non-AKI group. We analyzed the physiochemical parameters on survival at 24 h, 72 h, 1 week, 1 month, and 3 months after AKI. Results. Mortality rate was higher in the AKI group. AKI group had higher anion gap (AG), strong ion gap (SIG), and apparent strong ion difference (SIDa) values than non-AKI group. SIG value was higher in the AKI survivors than nonsurvivors and this value was correlated serum creatinine, phosphate, albumin, and chloride levels. SIG and serum albumin are negatively correlated with Acute Physiology and Chronic Health Evaluation IV scores. AG was associated with mortality at 1 and 3 months post-AKI, whereas SIG value was associated with mortality at 24 h, 72 h, 1 week, 1 month, and 3 months post-AKI. Conclusions. Whether high or low SIG values correlate with mortality in MA patients with AKI depends on its correlation with serum creatinine, chloride, albumin, and phosphate (P) levels. AG predicts short-term mortality and SIG value predicts both short- and long-term mortality among MA patients with AKI.

Original languageEnglish
Article number819528
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Zheng, C. M., Liu, W. C., Zheng, J. Q., Liao, M. T., Ma, W. Y., Hung, K. C., Lu, C. L., Wu, C. C., & Lu, K. C. (2014). Metabolic acidosis and strong ion gap in critically ill patients with acute kidney injury. BioMed Research International, 2014, [819528]. https://doi.org/10.1155/2014/819528