Meta-analysis study of lymph node staging by 18 F-FDG PET/CT scan in non-small cell lung cancer: Comparison of TB and non-TB endemic regions

Chih Ying Liao, Jin Hua Chen, Ji An Liang, Jun Jun Yeh, Chia Hung Kao

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Lymph node staging in non-small cell lung cancer (NSCLC) is challenging and important for deciding treatment policy. The role of PET/CT scans in lymph node staging of NSCLC remains controversial when comparing TB and non-TB endemic regions. This study systematically reviews the literature regarding the diagnostic performance of PET/CT in lymph node staging of patients with NSCLC, and determines its pooled sensitivity and specicity. Methods: The databases of PubMed, Medline, and Cochrane library were searched for relevant studies. Two reviewers independently assessed the methodological quality of each study. A meta-analysis of the reported sensitivity and specicity of each study was performed. Results: Seven of 86 studies were included. These studies had moderate to good methodological quality. Pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio for patient-based analyses (five studies) were 66%, 92.7%, 5.86%, and 0.41%, respectively, and those for lesion-based analyses (six studies) were 59.4%, 96.5%, 9.37%, and 0.31%, respectively. Subanalysis of endemic regions of tuberculosis (TB) showed that these regions had lower sensitivity and similar specificity to non-TB endemic regions. Conclusion: PET/CT showed high specificity in the lymph node staging of NSCLC and lower sensitivity in TB endemic regions.

Original languageEnglish
Pages (from-to)3518-3523
Number of pages6
JournalEuropean Journal of Radiology
Volume81
Issue number11
DOIs
Publication statusPublished - Nov 2012
Externally publishedYes

Fingerprint

Non-Small Cell Lung Carcinoma
Meta-Analysis
Tuberculosis
Lymph Nodes
Sensitivity and Specificity
PubMed
Libraries
Databases
Positron Emission Tomography Computed Tomography
Therapeutics

Keywords

  • FDG PET/CT
  • Lymph node staging
  • Meta-analysis
  • Non-small cell lung cancer
  • TB

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Meta-analysis study of lymph node staging by 18 F-FDG PET/CT scan in non-small cell lung cancer : Comparison of TB and non-TB endemic regions. / Liao, Chih Ying; Chen, Jin Hua; Liang, Ji An; Yeh, Jun Jun; Kao, Chia Hung.

In: European Journal of Radiology, Vol. 81, No. 11, 11.2012, p. 3518-3523.

Research output: Contribution to journalArticle

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abstract = "Lymph node staging in non-small cell lung cancer (NSCLC) is challenging and important for deciding treatment policy. The role of PET/CT scans in lymph node staging of NSCLC remains controversial when comparing TB and non-TB endemic regions. This study systematically reviews the literature regarding the diagnostic performance of PET/CT in lymph node staging of patients with NSCLC, and determines its pooled sensitivity and specicity. Methods: The databases of PubMed, Medline, and Cochrane library were searched for relevant studies. Two reviewers independently assessed the methodological quality of each study. A meta-analysis of the reported sensitivity and specicity of each study was performed. Results: Seven of 86 studies were included. These studies had moderate to good methodological quality. Pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio for patient-based analyses (five studies) were 66{\%}, 92.7{\%}, 5.86{\%}, and 0.41{\%}, respectively, and those for lesion-based analyses (six studies) were 59.4{\%}, 96.5{\%}, 9.37{\%}, and 0.31{\%}, respectively. Subanalysis of endemic regions of tuberculosis (TB) showed that these regions had lower sensitivity and similar specificity to non-TB endemic regions. Conclusion: PET/CT showed high specificity in the lymph node staging of NSCLC and lower sensitivity in TB endemic regions.",
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