Meta-analysis of the diagnostic performance of [18F]FDG-PET and PET/CT in renal cell carcinoma

Hsin Yi Wang, Hueisch Jy Ding, Jin Hua Chen, Chih Hao Chao, Yu Yu Lu, Wan Yu Lin, Chia Hung Kao

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Objectives: Positron emission tomography (PET) using fluorodeoxyglucose (FDG) is useful for restaging renal cell carcinoma (RCC) and detecting metastatic diseases but is less satisfactory for detecting primary disease. We evaluated whether the integration of computed tomography (CT) scans with the PET system could increase the applicability of FDG-PET for RCC. Methods: The MEDLINE databases were searched for relevant studies published since 2001. Two reviewers independently assessed the methodological quality of each study identified. We then performed a meta-analysis of the sensitivity and specificity of FDG-PET findings as reported in all the selected studies. Results: Fourteen studies were eligible for inclusion. The pooled sensitivity and specificity of FDG-PET were 62% and 88% respectively, for renal lesions. For detecting extra-renal lesions, the pooled sensitivity and specificity of FDG-PET were 79% and 90%, respectively, based on the scans, and 84% and 91% based on the lesions. The use of a hybrid FDG-PET/CT to detect extra-renal lesions increased the pooled sensitivity and specificity to 91% and 88%, respectively, with good consistency. Conclusions: For RCC, combining the FDG-PET and CT systems is helpful for detecting extra-renal metastasis rather than renal lesions. The hybrid PET/CT system has comparable sensitivity and specificity with PET in detecting extra-renal lesions of RCC. Advances in knowledge: The FDG-PET and PET/CT systems are both useful for detecting extra-renal metastasis in renal cell carcinoma.

Original languageEnglish
Pages (from-to)464-474
Number of pages11
JournalCancer Imaging
Volume12
Issue number3
DOIs
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Fluorodeoxyglucose F18
Renal Cell Carcinoma
Positron-Emission Tomography
Meta-Analysis
Kidney
Sensitivity and Specificity
Neoplasm Metastasis
Positron Emission Tomography Computed Tomography
MEDLINE
Tomography
Databases

Keywords

  • FDG
  • Meta-analysis
  • PET
  • PET/CT
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Meta-analysis of the diagnostic performance of [18F]FDG-PET and PET/CT in renal cell carcinoma. / Wang, Hsin Yi; Ding, Hueisch Jy; Chen, Jin Hua; Chao, Chih Hao; Lu, Yu Yu; Lin, Wan Yu; Kao, Chia Hung.

In: Cancer Imaging, Vol. 12, No. 3, 2012, p. 464-474.

Research output: Contribution to journalArticle

Wang, Hsin Yi ; Ding, Hueisch Jy ; Chen, Jin Hua ; Chao, Chih Hao ; Lu, Yu Yu ; Lin, Wan Yu ; Kao, Chia Hung. / Meta-analysis of the diagnostic performance of [18F]FDG-PET and PET/CT in renal cell carcinoma. In: Cancer Imaging. 2012 ; Vol. 12, No. 3. pp. 464-474.
@article{6f3a39eee1e643beaf4d29d1ef986a0d,
title = "Meta-analysis of the diagnostic performance of [18F]FDG-PET and PET/CT in renal cell carcinoma",
abstract = "Objectives: Positron emission tomography (PET) using fluorodeoxyglucose (FDG) is useful for restaging renal cell carcinoma (RCC) and detecting metastatic diseases but is less satisfactory for detecting primary disease. We evaluated whether the integration of computed tomography (CT) scans with the PET system could increase the applicability of FDG-PET for RCC. Methods: The MEDLINE databases were searched for relevant studies published since 2001. Two reviewers independently assessed the methodological quality of each study identified. We then performed a meta-analysis of the sensitivity and specificity of FDG-PET findings as reported in all the selected studies. Results: Fourteen studies were eligible for inclusion. The pooled sensitivity and specificity of FDG-PET were 62{\%} and 88{\%} respectively, for renal lesions. For detecting extra-renal lesions, the pooled sensitivity and specificity of FDG-PET were 79{\%} and 90{\%}, respectively, based on the scans, and 84{\%} and 91{\%} based on the lesions. The use of a hybrid FDG-PET/CT to detect extra-renal lesions increased the pooled sensitivity and specificity to 91{\%} and 88{\%}, respectively, with good consistency. Conclusions: For RCC, combining the FDG-PET and CT systems is helpful for detecting extra-renal metastasis rather than renal lesions. The hybrid PET/CT system has comparable sensitivity and specificity with PET in detecting extra-renal lesions of RCC. Advances in knowledge: The FDG-PET and PET/CT systems are both useful for detecting extra-renal metastasis in renal cell carcinoma.",
keywords = "FDG, Meta-analysis, PET, PET/CT, Renal cell carcinoma",
author = "Wang, {Hsin Yi} and Ding, {Hueisch Jy} and Chen, {Jin Hua} and Chao, {Chih Hao} and Lu, {Yu Yu} and Lin, {Wan Yu} and Kao, {Chia Hung}",
year = "2012",
doi = "10.1102/1470-7330.2012.0042",
language = "English",
volume = "12",
pages = "464--474",
journal = "Cancer Imaging",
issn = "1740-5025",
publisher = "e-med",
number = "3",

}

TY - JOUR

T1 - Meta-analysis of the diagnostic performance of [18F]FDG-PET and PET/CT in renal cell carcinoma

AU - Wang, Hsin Yi

AU - Ding, Hueisch Jy

AU - Chen, Jin Hua

AU - Chao, Chih Hao

AU - Lu, Yu Yu

AU - Lin, Wan Yu

AU - Kao, Chia Hung

PY - 2012

Y1 - 2012

N2 - Objectives: Positron emission tomography (PET) using fluorodeoxyglucose (FDG) is useful for restaging renal cell carcinoma (RCC) and detecting metastatic diseases but is less satisfactory for detecting primary disease. We evaluated whether the integration of computed tomography (CT) scans with the PET system could increase the applicability of FDG-PET for RCC. Methods: The MEDLINE databases were searched for relevant studies published since 2001. Two reviewers independently assessed the methodological quality of each study identified. We then performed a meta-analysis of the sensitivity and specificity of FDG-PET findings as reported in all the selected studies. Results: Fourteen studies were eligible for inclusion. The pooled sensitivity and specificity of FDG-PET were 62% and 88% respectively, for renal lesions. For detecting extra-renal lesions, the pooled sensitivity and specificity of FDG-PET were 79% and 90%, respectively, based on the scans, and 84% and 91% based on the lesions. The use of a hybrid FDG-PET/CT to detect extra-renal lesions increased the pooled sensitivity and specificity to 91% and 88%, respectively, with good consistency. Conclusions: For RCC, combining the FDG-PET and CT systems is helpful for detecting extra-renal metastasis rather than renal lesions. The hybrid PET/CT system has comparable sensitivity and specificity with PET in detecting extra-renal lesions of RCC. Advances in knowledge: The FDG-PET and PET/CT systems are both useful for detecting extra-renal metastasis in renal cell carcinoma.

AB - Objectives: Positron emission tomography (PET) using fluorodeoxyglucose (FDG) is useful for restaging renal cell carcinoma (RCC) and detecting metastatic diseases but is less satisfactory for detecting primary disease. We evaluated whether the integration of computed tomography (CT) scans with the PET system could increase the applicability of FDG-PET for RCC. Methods: The MEDLINE databases were searched for relevant studies published since 2001. Two reviewers independently assessed the methodological quality of each study identified. We then performed a meta-analysis of the sensitivity and specificity of FDG-PET findings as reported in all the selected studies. Results: Fourteen studies were eligible for inclusion. The pooled sensitivity and specificity of FDG-PET were 62% and 88% respectively, for renal lesions. For detecting extra-renal lesions, the pooled sensitivity and specificity of FDG-PET were 79% and 90%, respectively, based on the scans, and 84% and 91% based on the lesions. The use of a hybrid FDG-PET/CT to detect extra-renal lesions increased the pooled sensitivity and specificity to 91% and 88%, respectively, with good consistency. Conclusions: For RCC, combining the FDG-PET and CT systems is helpful for detecting extra-renal metastasis rather than renal lesions. The hybrid PET/CT system has comparable sensitivity and specificity with PET in detecting extra-renal lesions of RCC. Advances in knowledge: The FDG-PET and PET/CT systems are both useful for detecting extra-renal metastasis in renal cell carcinoma.

KW - FDG

KW - Meta-analysis

KW - PET

KW - PET/CT

KW - Renal cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=84870562414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870562414&partnerID=8YFLogxK

U2 - 10.1102/1470-7330.2012.0042

DO - 10.1102/1470-7330.2012.0042

M3 - Article

VL - 12

SP - 464

EP - 474

JO - Cancer Imaging

JF - Cancer Imaging

SN - 1740-5025

IS - 3

ER -