Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women

Zhaoming Wang, Wei Jie Seow, Kouya Shiraishi, Chao A. Hsiung, Keitaro Matsuo, Jie Liu, Kexin Chen, Taiki Yamji, Yang Yang, I. Shou Chang, Chen Wu, Yun Chul Hong, Laurie Burdett, Kathleen Wyatt, Charles C. Chung, Shengchao A. Li, Meredith Yeager, Amy Hutchinson, Wei Hu, Neil CaporasoMaria T. Landi, Nilanjan Chatterjee, Minsun Song, Joseph F. Fraumeni, Takashi Kohno, Jun Yokota, Hideo Kunitoh, Kyota Ashikawa, Yukihide Momozawa, Yataro Daigo, Tetsuya Mitsudomi, Yasushi Yatabe, Toyoaki Hida, Zhibin Hu, Juncheng Dai, Hongxia Ma, Guangfu Jin, Bao Song, Zhehai Wang, Sensen Cheng, Zhihua Yin, Xuelian Li, Yangwu Ren, Peng Guan, Jiang Chang, Wen Tan, Chien Jen Chen, Gee Chen Chang, Ying Huang Tsai, Wu Chou Su, Kuan Yu Chen, Ming Shyan Huang, Yuh Min Chen, Hong Zheng, Haixin Li, Ping Cui, Huan Guo, Ping Xu, Li Liu, Motoki Iwasaki, Taichi Shimazu, Shoichiro Tsugane, Junjie Zhu, Gening Jiang, Ke Fei, Jae Yong Park, Yeul Hong Kim, Jae Sook Sung, Kyong Hwa Park, Young Tae Kim, Yoo Jin Jung, Chang Hyun Kang, In Kyu Park, Hee Nam Kim, Hyo Sung Jeon, Jin Eun Choi, Yi Young Choi, Jin Hee Kim, In Jae Oh, Young Chul Kim, Sook Whan Sung, Jun Suk Kim, Ho Il Yoon, Sun Seog Kweon, Min Ho Shin, Adeline Seow, Ying Chen, Wei Yen Lim, Jianjun Liu, Maria Pik Wong, Victor Ho Fun Lee, Bryan A. Bassig, Margaret Tucker, Sonja I. Berndt, Wong Ho Chow, Bu Tian Ji, Junwen Wang, Jun Xu, Alan Dart Loon Sihoe, James C.M. Ho, John K.C. Chan, Jiu Cun Wang, Daru Lu, Xueying Zhao, Zhenhong Zhao, Junjie Wu, Hongyan Chen, Li Jin, Fusheng Wei, Guoping Wu, She Juan An, Xu Chao Zhang, Jian Su, Yi Long Wu, Yu Tang Gao, Yong Bing Xiang, Xingzhou He, Jihua Li, Wei Zheng, Xiao Ou Shu, Qiuyin Cai, Robert Klein, William Pao, Charles Lawrence, H. Dean Hosgood, Chin Fu Hsiao, Li Hsin Chien, Ying Hsiang Chen, Chung Hsing Chen, Wen Chang Wang, Chih Yi Chen, Chih Liang Wang, Chong Jen Yu, Hui Ling Chen, Yu Chun Su, Fang Yu Tsai, Yi Song Chen, Yao Jen Li, Tsung Ying Yang, Chien Chung Lin, Pan Chyr Yang, Tangchun Wu, Dongxin Lin, Baosen Zhou, Jinming Yu, Hongbing Shen, Michiaki Kubo, Stephen J. Chanock, Nathaniel Rothman, Qing Lan

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR) = 1.17; P = 5.8 × 10-13), rs72658409 at 9p21.3 (per-allele OR = 0.77; P = 1.41 × 10-10) and rs11610143 at 12q13.13 (per-allele OR = 0.89; P = 4.96 × 10-9). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings.

Original languageEnglish
Pages (from-to)620-629
Number of pages10
JournalHuman Molecular Genetics
Volume25
Issue number3
DOIs
Publication statusPublished - Feb 1 2016

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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    Wang, Z., Seow, W. J., Shiraishi, K., Hsiung, C. A., Matsuo, K., Liu, J., Chen, K., Yamji, T., Yang, Y., Chang, I. S., Wu, C., Hong, Y. C., Burdett, L., Wyatt, K., Chung, C. C., Li, S. A., Yeager, M., Hutchinson, A., Hu, W., ... Lan, Q. (2016). Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women. Human Molecular Genetics, 25(3), 620-629. https://doi.org/10.1093/hmg/ddv494