Mesoporous silica nanoparticles functionalized with an oxygen-sensing probe for cell photodynamic therapy: Potential cancer theranostics

Shih Hsun Cheng, Chia Hung Lee, Chung Shi Yang, Fan Gang Tseng, Chung Yuan Mou, Leu Wei Lo

Research output: Contribution to journalArticlepeer-review

132 Citations (Scopus)

Abstract

Functionalization of mesoporous silica nanoparticles (MSNs) with Pd-porphyrins for cancer cell photodynamic therapy is reported. The composite platform, MSN-PdTPP, expands the role of Pd-porphyrins from their routine use as phosphorescence probes for oxygen sensing/imaging (diagnostics) to that of novel nano-photosensitizers for cancer cell phototherapy (therapeutics). The utility of MSN-PdTPP in the phototherapeutic treatment of MDA-MB-231 breast cancer cells is also evaluated, suggesting it is a promising cancer theranostic platform.

Original languageEnglish
Pages (from-to)1252-1257
Number of pages6
JournalJournal of Materials Chemistry
Volume19
Issue number9
DOIs
Publication statusPublished - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

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