Mesoporous silica nanoparticles as nanocarriers

Si Han Wu, Yann Hung, Chung Yuan Mou

Research output: Contribution to journalArticle

207 Citations (Scopus)

Abstract

Modern nanomedicine aims at delivering drugs or cells specifically to defective cells; therefore, this calls for developing multifunctional nanocarriers for drug delivery and cell-tracking. Mesoporous silica nanoparticles (MSNs) are well suited for this task. In this feature article, we highlight the strategies in the synthesis and functionalization of small, uniform and colloidal stable MSNs. We then discuss cell uptake of MSNs and tracking cells, as both aspects are closely related to the efficacy of drug delivery and theranostics. Some examples of stimulated drug delivery are described. For application considerations, toxicity and pharmacokinetics are critical issues and in vivo studies are summarized.

Original languageEnglish
Pages (from-to)9972-9985
Number of pages14
JournalChemical Communications
Volume47
Issue number36
DOIs
Publication statusPublished - Sep 28 2011
Externally publishedYes

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Drug delivery
Silicon Dioxide
Silica
Nanoparticles
Medical nanotechnology
Pharmacokinetics
Toxicity
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Mesoporous silica nanoparticles as nanocarriers. / Wu, Si Han; Hung, Yann; Mou, Chung Yuan.

In: Chemical Communications, Vol. 47, No. 36, 28.09.2011, p. 9972-9985.

Research output: Contribution to journalArticle

Wu, Si Han ; Hung, Yann ; Mou, Chung Yuan. / Mesoporous silica nanoparticles as nanocarriers. In: Chemical Communications. 2011 ; Vol. 47, No. 36. pp. 9972-9985.
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