Mesoporous europium-doped titania nanoparticles (Eu-MTNs) for luminescence-based intracellular bio-imaging

Kuan Chou Chen, Saikat Dutta, Yusuke Yamauchi, Saad M. Alshehri, Mai Thanh Nguyen, Tetsu Yonezawa, Kun Hung Shen, Kevin C W Wu

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4 Citations (Scopus)


Monodisperse and mesoporous europium (Eu)-doped titania nanoparticles (denoted as Eu-MTNs) were prepared by a co-synthesis method with the presence of a cationic surfactant (i.e., CTAB). A maximum loading amount of 8 mol% of Eu could be successfully incorporated into the framework of MTNs. The synthesized Eu-MTNs samples were characterized with X-ray diffraction (XRD) and scanning electron microscopy (SEM), with their luminescent property examined by photoluminescence (PL). Under ultraviolet irradiation, the Eu-MTNs samples exhibit several characteristic luminescence corresponding to 5D0 -7Fj for Eu+3 ions, which can be attributed to the energy transfer from titania nanocrystallite to Eu3+ ions dispersed in amorphous mesoporous titania region. The potential intracellular bio-imaging application of the synthesized Eu-MTN nanoparticles was demonstrated with a breast cancer cell line (i.e., BT-20). High biocompatibility and strong luminescence of the Eu-MTNs show great potential in biomedical applications.

Original languageEnglish
Pages (from-to)9802-9806
Number of pages5
JournalJournal of Nanoscience and Nanotechnology
Issue number12
Publication statusPublished - Dec 1 2015


  • Bio-imaging
  • Europium
  • Mesoporous
  • Nanoparticles
  • Titania

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Chemistry(all)
  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering

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  • Cite this

    Chen, K. C., Dutta, S., Yamauchi, Y., Alshehri, S. M., Nguyen, M. T., Yonezawa, T., Shen, K. H., & Wu, K. C. W. (2015). Mesoporous europium-doped titania nanoparticles (Eu-MTNs) for luminescence-based intracellular bio-imaging. Journal of Nanoscience and Nanotechnology, 15(12), 9802-9806.