Mesoporous europium-doped titania nanoparticles (Eu-MTNs) for luminescence-based intracellular bio-imaging

Kuan Chou Chen, Saikat Dutta, Yusuke Yamauchi, Saad M. Alshehri, Mai Thanh Nguyen, Tetsu Yonezawa, Kun Hung Shen, Kevin C W Wu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Monodisperse and mesoporous europium (Eu)-doped titania nanoparticles (denoted as Eu-MTNs) were prepared by a co-synthesis method with the presence of a cationic surfactant (i.e., CTAB). A maximum loading amount of 8 mol% of Eu could be successfully incorporated into the framework of MTNs. The synthesized Eu-MTNs samples were characterized with X-ray diffraction (XRD) and scanning electron microscopy (SEM), with their luminescent property examined by photoluminescence (PL). Under ultraviolet irradiation, the Eu-MTNs samples exhibit several characteristic luminescence corresponding to 5D0 -7Fj for Eu+3 ions, which can be attributed to the energy transfer from titania nanocrystallite to Eu3+ ions dispersed in amorphous mesoporous titania region. The potential intracellular bio-imaging application of the synthesized Eu-MTN nanoparticles was demonstrated with a breast cancer cell line (i.e., BT-20). High biocompatibility and strong luminescence of the Eu-MTNs show great potential in biomedical applications.

Original languageEnglish
Pages (from-to)9802-9806
Number of pages5
JournalJournal of Nanoscience and Nanotechnology
Volume15
Issue number12
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Europium
europium
Luminescence
Nanoparticles
titanium
Titanium
luminescence
Imaging techniques
nanoparticles
Ions
titanium dioxide
Cationic surfactants
Energy Transfer
biocompatibility
Biocompatibility
cultured cells
Surface-Active Agents
X-Ray Diffraction
breast
Electron Scanning Microscopy

Keywords

  • Bio-imaging
  • Europium
  • Mesoporous
  • Nanoparticles
  • Titania

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Chemistry(all)
  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering

Cite this

Mesoporous europium-doped titania nanoparticles (Eu-MTNs) for luminescence-based intracellular bio-imaging. / Chen, Kuan Chou; Dutta, Saikat; Yamauchi, Yusuke; Alshehri, Saad M.; Nguyen, Mai Thanh; Yonezawa, Tetsu; Shen, Kun Hung; Wu, Kevin C W.

In: Journal of Nanoscience and Nanotechnology, Vol. 15, No. 12, 01.12.2015, p. 9802-9806.

Research output: Contribution to journalArticle

Chen, Kuan Chou ; Dutta, Saikat ; Yamauchi, Yusuke ; Alshehri, Saad M. ; Nguyen, Mai Thanh ; Yonezawa, Tetsu ; Shen, Kun Hung ; Wu, Kevin C W. / Mesoporous europium-doped titania nanoparticles (Eu-MTNs) for luminescence-based intracellular bio-imaging. In: Journal of Nanoscience and Nanotechnology. 2015 ; Vol. 15, No. 12. pp. 9802-9806.
@article{d4e341a37a264e6dae13bc4c7581603a,
title = "Mesoporous europium-doped titania nanoparticles (Eu-MTNs) for luminescence-based intracellular bio-imaging",
abstract = "Monodisperse and mesoporous europium (Eu)-doped titania nanoparticles (denoted as Eu-MTNs) were prepared by a co-synthesis method with the presence of a cationic surfactant (i.e., CTAB). A maximum loading amount of 8 mol{\%} of Eu could be successfully incorporated into the framework of MTNs. The synthesized Eu-MTNs samples were characterized with X-ray diffraction (XRD) and scanning electron microscopy (SEM), with their luminescent property examined by photoluminescence (PL). Under ultraviolet irradiation, the Eu-MTNs samples exhibit several characteristic luminescence corresponding to 5D0 -7Fj for Eu+3 ions, which can be attributed to the energy transfer from titania nanocrystallite to Eu3+ ions dispersed in amorphous mesoporous titania region. The potential intracellular bio-imaging application of the synthesized Eu-MTN nanoparticles was demonstrated with a breast cancer cell line (i.e., BT-20). High biocompatibility and strong luminescence of the Eu-MTNs show great potential in biomedical applications.",
keywords = "Bio-imaging, Europium, Mesoporous, Nanoparticles, Titania",
author = "Chen, {Kuan Chou} and Saikat Dutta and Yusuke Yamauchi and Alshehri, {Saad M.} and Nguyen, {Mai Thanh} and Tetsu Yonezawa and Shen, {Kun Hung} and Wu, {Kevin C W}",
year = "2015",
month = "12",
day = "1",
doi = "10.1166/jnn.2015.12329",
language = "English",
volume = "15",
pages = "9802--9806",
journal = "Journal of Nanoscience and Nanotechnology",
issn = "1533-4880",
publisher = "American Scientific Publishers",
number = "12",

}

TY - JOUR

T1 - Mesoporous europium-doped titania nanoparticles (Eu-MTNs) for luminescence-based intracellular bio-imaging

AU - Chen, Kuan Chou

AU - Dutta, Saikat

AU - Yamauchi, Yusuke

AU - Alshehri, Saad M.

AU - Nguyen, Mai Thanh

AU - Yonezawa, Tetsu

AU - Shen, Kun Hung

AU - Wu, Kevin C W

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Monodisperse and mesoporous europium (Eu)-doped titania nanoparticles (denoted as Eu-MTNs) were prepared by a co-synthesis method with the presence of a cationic surfactant (i.e., CTAB). A maximum loading amount of 8 mol% of Eu could be successfully incorporated into the framework of MTNs. The synthesized Eu-MTNs samples were characterized with X-ray diffraction (XRD) and scanning electron microscopy (SEM), with their luminescent property examined by photoluminescence (PL). Under ultraviolet irradiation, the Eu-MTNs samples exhibit several characteristic luminescence corresponding to 5D0 -7Fj for Eu+3 ions, which can be attributed to the energy transfer from titania nanocrystallite to Eu3+ ions dispersed in amorphous mesoporous titania region. The potential intracellular bio-imaging application of the synthesized Eu-MTN nanoparticles was demonstrated with a breast cancer cell line (i.e., BT-20). High biocompatibility and strong luminescence of the Eu-MTNs show great potential in biomedical applications.

AB - Monodisperse and mesoporous europium (Eu)-doped titania nanoparticles (denoted as Eu-MTNs) were prepared by a co-synthesis method with the presence of a cationic surfactant (i.e., CTAB). A maximum loading amount of 8 mol% of Eu could be successfully incorporated into the framework of MTNs. The synthesized Eu-MTNs samples were characterized with X-ray diffraction (XRD) and scanning electron microscopy (SEM), with their luminescent property examined by photoluminescence (PL). Under ultraviolet irradiation, the Eu-MTNs samples exhibit several characteristic luminescence corresponding to 5D0 -7Fj for Eu+3 ions, which can be attributed to the energy transfer from titania nanocrystallite to Eu3+ ions dispersed in amorphous mesoporous titania region. The potential intracellular bio-imaging application of the synthesized Eu-MTN nanoparticles was demonstrated with a breast cancer cell line (i.e., BT-20). High biocompatibility and strong luminescence of the Eu-MTNs show great potential in biomedical applications.

KW - Bio-imaging

KW - Europium

KW - Mesoporous

KW - Nanoparticles

KW - Titania

UR - http://www.scopus.com/inward/record.url?scp=84956636007&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84956636007&partnerID=8YFLogxK

U2 - 10.1166/jnn.2015.12329

DO - 10.1166/jnn.2015.12329

M3 - Article

VL - 15

SP - 9802

EP - 9806

JO - Journal of Nanoscience and Nanotechnology

JF - Journal of Nanoscience and Nanotechnology

SN - 1533-4880

IS - 12

ER -