Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

Wei Zhan Zhuang, Yi Heng Lin, Long Jyun Su, Meng Shiue Wu, Han Yin Jeng, Huan Cheng Chang, Yen Hua Huang, Thai Yen Ling

Research output: Contribution to journalReview articlepeer-review

24 Citations (Scopus)

Abstract

Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy because of their high immunomodulation ability, tropism towards inflamed and injured tissues, and their easy access and isolation. Currently, there are more than 1200 registered MSC clinical trials globally. However, a lack of standardized methods to characterize cell safety, efficacy, and biodistribution dramatically hinders the progress of MSC utility in clinical practice. In this review, we summarize the current state of MSC-based cell therapy, focusing on the systemic safety and biodistribution of MSCs. MSC-associated risks of tumor initiation and promotion and the underlying mechanisms of these risks are discussed. In addition, MSC biodistribution methodology and the pharmacokinetics and pharmacodynamics of cell therapies are addressed. Better understanding of the systemic safety and biodistribution of MSCs will facilitate future clinical applications of precision medicine using stem cells.

Original languageEnglish
Article number28
JournalJournal of Biomedical Science
Volume28
Issue number1
DOIs
Publication statusPublished - Dec 2021

Keywords

  • biodistribution
  • Cell therapy
  • Mesenchymal stem/stromal cell
  • Single cell imaging
  • Systemic safety

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

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