Mesenchymal stem cell therapy for nonmusculoskeletal diseases: Emerging applications

Tom K. Kuo, Jennifer H. Ho, Oscar K. Lee

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Mesenchymal stem cells are stem/progenitor cells originated from the mesoderm and can different into multiple cell types of the musculoskeletal system. The vast differentiation potential and the relative ease for culture expansion have established mesenchymal stem cells as the building blocks in cell therapy and tissue engineering applications for a variety of musculoskeletal diseases, including repair of fractures and bone defects, cartilage regeneration, treatment of osteonecrosis of the femoral head, and correction of genetic diseases such as osteogenesis imperfect. However, research in the past decade has revealed differentiation potentials of mesenchymal stem cells beyond lineages of the mesoderm, suggesting broader applications than originally perceived. In this article, we review the recent developments in mesenchymal stem cell research with respect to their emerging properties and applications in nonmusculoskeletal diseases.

Original languageEnglish
Pages (from-to)1013-1028
Number of pages16
JournalCell Transplantation
Volume18
Issue number9
DOIs
Publication statusPublished - 2009

Keywords

  • Hepatic failure
  • Immunoregulation
  • Mesenchymal stem cells
  • Myocardial infarction
  • Ocular disease
  • Stem cell therapy

ASJC Scopus subject areas

  • Cell Biology
  • Biomedical Engineering
  • Transplantation

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