Meperidine as the single sedative agent during esophagogastroduodenoscopy, a double-blind, randomized, controlled study

Yu Hsi Hsieh, Hwai Jeng Lin, Jin Jian Hsieh, Kuo Chih Tseng, Chih Wei Tseng, Tsung Hsing Hung, Felix W. Leung

Research output: Contribution to journalArticle

4 Citations (Scopus)


Background and Aim: In Taiwan, unsedated esophagogastroduodenoscopy (EGD) is widely used, but it is uncomfortable for some patients. While meperidine has been adopted in colonoscopy, its use in EGD has not received extensive attention. This was a prospective study to investigate the use of meperidine as a single sedative agent during EGD. Methods: One hundred and forty patients were randomized to receive either 25-mg meperidine (n=70) or placebo (n=70) by intramuscular injection before EGD. The primary outcome was patient discomfort scores. The secondary outcomes included patient, endoscopist, and EGD-related variables. Results: Patients in the meperidine group reported less discomfort during esophageal intubation (median score of 2.0 and interquartile range [IQR] of 0-4.0 vs median score of 4.8 and IQR of 1.7-7.0, respectively; P

Original languageEnglish
Pages (from-to)1167-1173
Number of pages7
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue number7
Publication statusPublished - 2013



  • Esophagogastroduodenoscopy
  • Meperidine
  • Minimal sedation

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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