Meperidine as the single sedative agent during esophagogastroduodenoscopy, a double-blind, randomized, controlled study

Yu Hsi Hsieh; Hwai Jeng Lin; Jin Jian Hsieh; Kuo Chih Tseng; Chih Wei Tseng; Tsung Hsing Hung; Felix W. Leung

doi:10.1111/jgh.12183

Meperidine as the single sedative agent during esophagogastroduodenoscopy, a double-blind, randomized, controlled study

Yu Hsi Hsieh, Hwai Jeng Lin, Jin Jian Hsieh, Kuo Chih Tseng, Chih Wei Tseng, Tsung Hsing Hung, Felix W. Leung

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Background and Aim: In Taiwan, unsedated esophagogastroduodenoscopy (EGD) is widely used, but it is uncomfortable for some patients. While meperidine has been adopted in colonoscopy, its use in EGD has not received extensive attention. This was a prospective study to investigate the use of meperidine as a single sedative agent during EGD. Methods: One hundred and forty patients were randomized to receive either 25-mg meperidine (n=70) or placebo (n=70) by intramuscular injection before EGD. The primary outcome was patient discomfort scores. The secondary outcomes included patient, endoscopist, and EGD-related variables. Results: Patients in the meperidine group reported less discomfort during esophageal intubation (median score of 2.0 and interquartile range [IQR] of 0-4.0 vs median score of 4.8 and IQR of 1.7-7.0, respectively; P

Original language	English
Pages (from-to)	1167-1173
Number of pages	7
Journal	Journal of Gastroenterology and Hepatology (Australia)
Volume	28
Issue number	7
DOIs	https://doi.org/10.1111/jgh.12183
Publication status	Published - 2013

Keywords

Esophagogastroduodenoscopy
Meperidine
Minimal sedation

ASJC Scopus subject areas

Gastroenterology
Hepatology

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10.1111/jgh.12183

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Meperidine as the single sedative agent during esophagogastroduodenoscopy, a double-blind, randomized, controlled study. / Hsieh, Yu Hsi; Lin, Hwai Jeng; Hsieh, Jin Jian; Tseng, Kuo Chih; Tseng, Chih Wei; Hung, Tsung Hsing; Leung, Felix W.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 28, No. 7, 2013, p. 1167-1173.

Research output: Contribution to journal › Article › peer-review

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abstract = "Background and Aim: In Taiwan, unsedated esophagogastroduodenoscopy (EGD) is widely used, but it is uncomfortable for some patients. While meperidine has been adopted in colonoscopy, its use in EGD has not received extensive attention. This was a prospective study to investigate the use of meperidine as a single sedative agent during EGD. Methods: One hundred and forty patients were randomized to receive either 25-mg meperidine (n=70) or placebo (n=70) by intramuscular injection before EGD. The primary outcome was patient discomfort scores. The secondary outcomes included patient, endoscopist, and EGD-related variables. Results: Patients in the meperidine group reported less discomfort during esophageal intubation (median score of 2.0 and interquartile range [IQR] of 0-4.0 vs median score of 4.8 and IQR of 1.7-7.0, respectively; P",

keywords = "Esophagogastroduodenoscopy, Meperidine, Minimal sedation",

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AU - Tseng, Kuo Chih

AU - Tseng, Chih Wei

AU - Hung, Tsung Hsing

AU - Leung, Felix W.

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AB - Background and Aim: In Taiwan, unsedated esophagogastroduodenoscopy (EGD) is widely used, but it is uncomfortable for some patients. While meperidine has been adopted in colonoscopy, its use in EGD has not received extensive attention. This was a prospective study to investigate the use of meperidine as a single sedative agent during EGD. Methods: One hundred and forty patients were randomized to receive either 25-mg meperidine (n=70) or placebo (n=70) by intramuscular injection before EGD. The primary outcome was patient discomfort scores. The secondary outcomes included patient, endoscopist, and EGD-related variables. Results: Patients in the meperidine group reported less discomfort during esophageal intubation (median score of 2.0 and interquartile range [IQR] of 0-4.0 vs median score of 4.8 and IQR of 1.7-7.0, respectively; P

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