Meningeal carcinomatosis from solid tumors: clinical analysis of 42 cases.

C. C. Liaw, K. T. Ng, J. S. Huang, C. H. Wang, M. C. Kiu, G. M. Lai

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

From January 1984 to June 1990, we observed 42 patients with meningeal carcinomatosis, 20 men and 22 women, aged 21 to 80 years (median age, 53 years). The two most common primary malignancies were lung cancer (50%) and breast cancer (31%). Sixty-four per cent was adenocarcinoma. On the first lumbar puncture, 86% had malignant cells in the cerebrospinal fluid. The findings of brain computed tomography were hydrocephalus (62%), contrast enhancement in the cerebral sulci or basal cisterns (31%), concomitant parenchymal metastases (15%) and normal scan (18%). In five out of seven cases, myelography showed irregular filling defects over the spinal cord or cauda equina. Treatment results were evaluated in 24 patients. Eight received radiation therapy (RT) alone, and 16 had combined therapy with RT plus intrathecal methotrexate (IT MTX). Of the patients who received RT alone, only one patient with lung carcinoma was stabilized clinically. Of the cases receiving combined therapy, seven improved clinically. Six of these were patients with breast carcinoma who received IT MTX via Ommaya reservoir. The latter had a median survival of 23 weeks. The follow-up period of the entire group of patients ranged from one day to 50 weeks. The median survival was four weeks. Based on this study, combined therapy with RT and IT MTX is indicated for breast carcinoma with meningeal carcinomatosis, but the therapeutic effects are uncertain for lung carcinoma and other malignancies.

Original languageEnglish
Pages (from-to)299-303
Number of pages5
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume91
Issue number3
Publication statusPublished - Mar 1992
Externally publishedYes

Fingerprint

Meningeal Carcinomatosis
Radiotherapy
Methotrexate
Breast Neoplasms
Neoplasms
Carcinoma
Cauda Equina
Lung
Myelography
Spinal Puncture
Survival
Therapeutic Uses
Therapeutics
Hydrocephalus
Cerebrospinal Fluid
Lung Neoplasms
Spinal Cord
Adenocarcinoma
Tomography
Neoplasm Metastasis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Meningeal carcinomatosis from solid tumors : clinical analysis of 42 cases. / Liaw, C. C.; Ng, K. T.; Huang, J. S.; Wang, C. H.; Kiu, M. C.; Lai, G. M.

In: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 91, No. 3, 03.1992, p. 299-303.

Research output: Contribution to journalArticle

Liaw, C. C. ; Ng, K. T. ; Huang, J. S. ; Wang, C. H. ; Kiu, M. C. ; Lai, G. M. / Meningeal carcinomatosis from solid tumors : clinical analysis of 42 cases. In: Journal of the Formosan Medical Association = Taiwan yi zhi. 1992 ; Vol. 91, No. 3. pp. 299-303.
@article{5fc5502d66104aebb2ee79b371458f77,
title = "Meningeal carcinomatosis from solid tumors: clinical analysis of 42 cases.",
abstract = "From January 1984 to June 1990, we observed 42 patients with meningeal carcinomatosis, 20 men and 22 women, aged 21 to 80 years (median age, 53 years). The two most common primary malignancies were lung cancer (50{\%}) and breast cancer (31{\%}). Sixty-four per cent was adenocarcinoma. On the first lumbar puncture, 86{\%} had malignant cells in the cerebrospinal fluid. The findings of brain computed tomography were hydrocephalus (62{\%}), contrast enhancement in the cerebral sulci or basal cisterns (31{\%}), concomitant parenchymal metastases (15{\%}) and normal scan (18{\%}). In five out of seven cases, myelography showed irregular filling defects over the spinal cord or cauda equina. Treatment results were evaluated in 24 patients. Eight received radiation therapy (RT) alone, and 16 had combined therapy with RT plus intrathecal methotrexate (IT MTX). Of the patients who received RT alone, only one patient with lung carcinoma was stabilized clinically. Of the cases receiving combined therapy, seven improved clinically. Six of these were patients with breast carcinoma who received IT MTX via Ommaya reservoir. The latter had a median survival of 23 weeks. The follow-up period of the entire group of patients ranged from one day to 50 weeks. The median survival was four weeks. Based on this study, combined therapy with RT and IT MTX is indicated for breast carcinoma with meningeal carcinomatosis, but the therapeutic effects are uncertain for lung carcinoma and other malignancies.",
author = "Liaw, {C. C.} and Ng, {K. T.} and Huang, {J. S.} and Wang, {C. H.} and Kiu, {M. C.} and Lai, {G. M.}",
year = "1992",
month = "3",
language = "English",
volume = "91",
pages = "299--303",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Elsevier Science Publishers B.V.",
number = "3",

}

TY - JOUR

T1 - Meningeal carcinomatosis from solid tumors

T2 - clinical analysis of 42 cases.

AU - Liaw, C. C.

AU - Ng, K. T.

AU - Huang, J. S.

AU - Wang, C. H.

AU - Kiu, M. C.

AU - Lai, G. M.

PY - 1992/3

Y1 - 1992/3

N2 - From January 1984 to June 1990, we observed 42 patients with meningeal carcinomatosis, 20 men and 22 women, aged 21 to 80 years (median age, 53 years). The two most common primary malignancies were lung cancer (50%) and breast cancer (31%). Sixty-four per cent was adenocarcinoma. On the first lumbar puncture, 86% had malignant cells in the cerebrospinal fluid. The findings of brain computed tomography were hydrocephalus (62%), contrast enhancement in the cerebral sulci or basal cisterns (31%), concomitant parenchymal metastases (15%) and normal scan (18%). In five out of seven cases, myelography showed irregular filling defects over the spinal cord or cauda equina. Treatment results were evaluated in 24 patients. Eight received radiation therapy (RT) alone, and 16 had combined therapy with RT plus intrathecal methotrexate (IT MTX). Of the patients who received RT alone, only one patient with lung carcinoma was stabilized clinically. Of the cases receiving combined therapy, seven improved clinically. Six of these were patients with breast carcinoma who received IT MTX via Ommaya reservoir. The latter had a median survival of 23 weeks. The follow-up period of the entire group of patients ranged from one day to 50 weeks. The median survival was four weeks. Based on this study, combined therapy with RT and IT MTX is indicated for breast carcinoma with meningeal carcinomatosis, but the therapeutic effects are uncertain for lung carcinoma and other malignancies.

AB - From January 1984 to June 1990, we observed 42 patients with meningeal carcinomatosis, 20 men and 22 women, aged 21 to 80 years (median age, 53 years). The two most common primary malignancies were lung cancer (50%) and breast cancer (31%). Sixty-four per cent was adenocarcinoma. On the first lumbar puncture, 86% had malignant cells in the cerebrospinal fluid. The findings of brain computed tomography were hydrocephalus (62%), contrast enhancement in the cerebral sulci or basal cisterns (31%), concomitant parenchymal metastases (15%) and normal scan (18%). In five out of seven cases, myelography showed irregular filling defects over the spinal cord or cauda equina. Treatment results were evaluated in 24 patients. Eight received radiation therapy (RT) alone, and 16 had combined therapy with RT plus intrathecal methotrexate (IT MTX). Of the patients who received RT alone, only one patient with lung carcinoma was stabilized clinically. Of the cases receiving combined therapy, seven improved clinically. Six of these were patients with breast carcinoma who received IT MTX via Ommaya reservoir. The latter had a median survival of 23 weeks. The follow-up period of the entire group of patients ranged from one day to 50 weeks. The median survival was four weeks. Based on this study, combined therapy with RT and IT MTX is indicated for breast carcinoma with meningeal carcinomatosis, but the therapeutic effects are uncertain for lung carcinoma and other malignancies.

UR - http://www.scopus.com/inward/record.url?scp=0026828561&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026828561&partnerID=8YFLogxK

M3 - Article

C2 - 1354692

AN - SCOPUS:0026828561

VL - 91

SP - 299

EP - 303

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

IS - 3

ER -