Membranes of epitaxial-like packed, super aligned electrospun micron hollow poly(l-lactic acid) (PLLA) fibers

Keng Liang Ou, Chin Sung Chen, Li Hsiang Lin, Jen Chieh Lu, Yao Chi Shu, Wen Chin Tseng, Jen Chang Yang, Sheng Yang Lee, Chien Chung Chen

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Novel epitaxial-like packed, super aligned, mono-layered hollow fibrous membranes were prepared by co-axial electrospinning technology. PLLA pellets were dissolved in solvent mixture of dichloromethane and dimethyl formamide (DCM/DMF = 9:1) to prepare sheath solution dope with various concentrations (from 8 to 19 wt.%). Aqueous solution of poly-ethylene glycol (PEG) was used as core solution dope. During the electrospinning process, dope concentrations and feed rate ratios were adjusted, separately, to evaluate the formation of resulting membranes. With lower shell solution concentration (from 8 to 15 wt.%), the collected, flattened film showed arrangement of lower order. A stood-up film was clearly seen when concentration increased to 17 wt.% and higher. As the collecting time went longer, these fibers piled up and eventually, stood up as a thin film from the surface of collector. Increasing flow rate ratio (FRR) also resulted similar outcomes and verify the cause of this phenomenon. After washing with water, scanning electron microscopy (SEM) revealed sheets of mono-layered, micron-sized hollow fiber arrays which were well aligned and tightly packed, just like the epitaxial growth of some semiconducting materials. These perfectly aligned and tightly packed hollow fiber arrays can be considered as highly anisotropic scaffolds that mimic tissue structures, such as nerve tissue, vascular structure as well as other application.

Original languageEnglish
Pages (from-to)882-892
Number of pages11
JournalEuropean Polymer Journal
Volume47
Issue number5
DOIs
Publication statusPublished - May 2011

Fingerprint

lactic acid
Lactic acid
hollow
Lactic Acid
membranes
Membranes
fibers
Fibers
Electrospinning
Fibrous membranes
Tissue
Methylene Chloride
washing
Dichloromethane
nerves
Dimethylformamide
Epitaxial growth
sheaths
pellets
Washing

Keywords

  • Alignment
  • Electrospinning
  • Epitaxial
  • Hollow fiber
  • Membrane
  • Packing

ASJC Scopus subject areas

  • Polymers and Plastics
  • Physics and Astronomy(all)
  • Organic Chemistry

Cite this

Membranes of epitaxial-like packed, super aligned electrospun micron hollow poly(l-lactic acid) (PLLA) fibers. / Ou, Keng Liang; Chen, Chin Sung; Lin, Li Hsiang; Lu, Jen Chieh; Shu, Yao Chi; Tseng, Wen Chin; Yang, Jen Chang; Lee, Sheng Yang; Chen, Chien Chung.

In: European Polymer Journal, Vol. 47, No. 5, 05.2011, p. 882-892.

Research output: Contribution to journalArticle

Ou, Keng Liang ; Chen, Chin Sung ; Lin, Li Hsiang ; Lu, Jen Chieh ; Shu, Yao Chi ; Tseng, Wen Chin ; Yang, Jen Chang ; Lee, Sheng Yang ; Chen, Chien Chung. / Membranes of epitaxial-like packed, super aligned electrospun micron hollow poly(l-lactic acid) (PLLA) fibers. In: European Polymer Journal. 2011 ; Vol. 47, No. 5. pp. 882-892.
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